Advance Search
WANG Qi, ZHOU Xiangdong, HAN Zhong, LIU Chang. Effects of expression of activator protein-1 and polytumour activator in tissue of non-small cell lung cancer on prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 1-5. DOI: 10.7619/jcmp.20201847
Citation: WANG Qi, ZHOU Xiangdong, HAN Zhong, LIU Chang. Effects of expression of activator protein-1 and polytumour activator in tissue of non-small cell lung cancer on prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 1-5. DOI: 10.7619/jcmp.20201847
shu

Effects of expression of activator protein-1 and polytumour activator in tissue of non-small cell lung cancer on prognosis

  • Department of Respiratory Medicine, First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, 570000

More Information
  • Received Date: December 28, 2020
  • Available Online: April 20, 2021
  • Published Date: July 27, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To study the effects of activator protein-1 (AP-1) and polytumor activator factor (PEA3) levels in tissue of non-small cell lung cancer (NSCLC) on prognosis of patients.
      Methods  Lung cancer tissues and adjacent tissues more than 5 cm away from cancer tissues of 75 patients with NSCLC were collected. The expression levels of AP-1 and PEA3 in NSCLC lung cancer and adjacent tissues were detected by immunohistochemistry (SP), the relationships between their expressions and clinicopathological parameters of NSCLC patients were analyzed, Kaplan-Meier was used to analyze the relationships between AP-1, PEA3 expression and the prognosis of NSCLC patients, COX was used to analyze the risk factors affecting the poor prognosis of NSCLC patients.
      Results  The positive rates of AP-1 and PEA3 proteins in lung cancer tissues were significantly higher than those of adjacent tissues(P < 0.05). The positive expressions of AP-1 and PEA3 proteins in lung cancer tissues were related to smoking history, differentiation degree, TNM stage, lymph node metastasis and pleural metastasis of NSCLC patients (P < 0.05). The 5-year overall survival rate of patients with positive expressions of AP-1 and PEA3 proteins in lung cancer tissues was significantly lower than those with negative expressions (P < 0.05). The high TNM stage, pleural metastasis, positive expressions of AP-1 and PEA3 proteins in lung cancer tissues were risk factors affecting the poor prognosis of NSCLC patients (P < 0.05).
      Conclusion  The positive expression of AP-1 and PEA3 protein in lung cancer tissues affects the prognosis of NSCLC patients, and may have some clinical significance for the prognosis evaluation of NSCLC.
    • FullText(HTML)
    • References (16)
  • [1]
    齐德林, 张毅, 李洪利, 等. Galectin-3在非小细胞肺癌患者血清中的表达及其临床意义[J]. 中国肺癌杂志, 2020, 23(5): 333-336. https://www.cnki.com.cn/Article/CJFDTOTAL-FAIZ202005005.htm
    [2]
    中国临床肿瘤学会血管靶向治疗专家委员会, 非小细胞肺癌专家委员会, 非小细胞肺癌抗血管生成药物治疗专家组. 晚期非小细胞肺癌抗血管生成药物治疗中国专家共识(2019版)[J]. 中国肺癌杂志, 2019, 22(7): 401-412. https://www.cnki.com.cn/Article/CJFDTOTAL-FAIZ201907001.htm
    [3]
    肖成, 刘瑧. AP-1与甲状腺癌相关研究进展[J]. 现代肿瘤医学, 2019, 27(6): 1076-1079. doi: 10.3969/j.issn.1672-4992.2019.06.042
    [4]
    KOO J H, PLOUFFE S W, MENG Z, et al. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth[J]. Genes Dev, 2020, 34(1/2): 72-86. http://www.researchgate.net/publication/337933153_Induction_of_AP-1_by_YAPTAZ_contributes_to_cell_proliferation_and_organ_growth
    [5]
    XU Y, NOWRANGI D, LIANG H, et al. DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage[J]. J Neuroinflammation, 2020, 17(1): 130. doi: 10.1186/s12974-020-01794-5
    [6]
    黄东良, 谢菲岚, 刘璐, 等. PEA3转录因子在恶性肿瘤中的表达及作用[J]. 医学综述, 2019, 25(21): 4223-4227, 4232. doi: 10.3969/j.issn.1006-2084.2019.21.012
    [7]
    伍培, 黄铧, 秦婷婷, 等. 川崎病患儿外周血MIF/AP-1/MMP-9信号通路的表达及其临床意义[J]. 国际儿科学杂志, 2020, 47(7): 497-502. doi: 10.3760/cma.j.issn.1673-4408.2020.07.014
    [8]
    WANG Q, YANG S, WANG K, et al. MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer[J]. J Hematol Oncol, 2019, 12(1): 63-74. doi: 10.1186/s13045-019-0759-9
    [9]
    BODOR J N, BOUMBER Y, BORGHAEI H. Biomarkers for immune checkpoint inhibition in non-small cell lung cancer (NSCLC)[J]. Cancer, 2020, 126(2): 260-270. doi: 10.1002/cncr.32468
    [10]
    SUNDQVIST A, VASILAKI E, VOYTYUK O, et al. TGFbeta and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness[J]. Oncogene, 2020, 39(22): 4436-4449. doi: 10.1038/s41388-020-1299-z
    [11]
    ZHU G, CHENG Z, HUANG Y, et al. MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF-κB/AP-1 signaling pathway[J]. Int J Mol Med, 2020, 45(1): 131-140. http://www.ncbi.nlm.nih.gov/pubmed/31746347
    [12]
    LI S, UNG T T, NGUYEN T T, et al. Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-kappaB Activity[J]. Int J Mol Sci, 2020, 21(10): 3420-3420. doi: 10.3390/ijms21103420
    [13]
    王熠, 童国强, 计玉兵, 等. 非小细胞肺癌组织中NF-κB、AP-1、TLR2的表达及意义[J]. 癌症进展, 2018, 16(15): 1872-1874. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ201815015.htm
    [14]
    朱春兰, 张梦霞, 何金玉. 卵巢癌组织中多瘤促活化因子、髓样分化因子88的表达与患者浸润、转移的关系[J]. 医疗装备, 2018, 31(9): 22-23. doi: 10.3969/j.issn.1002-2376.2018.09.012
    [15]
    WANG Y, DING X S, LIU B, et al. ETV4 overexpression promotes progression of non-small cell lung cancer by upregulating PXN and MMP1 transcriptionally[J]. Mol Carcinog, 2020, 59(1): 73-86. doi: 10.1002/mc.23130
    [16]
    王颖, 刘英宇, 张文艳. TIPE2抑制AP-1蛋白增加人非小细胞肺癌细胞系NCI-H1975化疗敏感性的机制研究[J]. 中国免疫学杂志, 2018, 34(1): 40-43. doi: 10.3969/j.issn.1000-484X.2018.01.008
    • Related Articles

  • Related Articles

    [1]ZHOU Guangliang, ZHANG Guangliang, HU Haiyang, HU Yunnan, JU Jihui, HOU Ruixing. Effect observation of modified anchor technique in repairing avulsion injury of lateral collateral ligament of elbow joint[J]. Journal of Clinical Medicine in Practice, 2022, 26(17): 15-17, 23. DOI: 10.7619/jcmp.20221169
    [2]CHEN Pengtao, WANG Jingcheng, HE Jinshan, ZHANG Pei, ZHANG Jiale, LIANG Yuan. Effect of suture anchor technology in treatment of patients with distal tibiofibular syndesmosis injury[J]. Journal of Clinical Medicine in Practice, 2022, 26(4): 89-91. DOI: 10.7619/jcmp.20212976
    [3]LU Yaojia, FEI Wenyong, XIONG Chuanzhi, HU Hansheng, CHEN Gang, WANG Qiang, GUO Dan, WEN Dan. Suture anchors versus hook plates in treatment of patients with acute acromioclavicular joint dislocation[J]. Journal of Clinical Medicine in Practice, 2020, 24(10): 21-24. DOI: 10.7619/jcmp.202010005
    [4]HU Jinlong, WANG Hua, WANG Jingcheng, CHEN Pengtao. Effect of suture anchors combined with Krackowsuture in treating the extremely comminuted fracture of middle and inferior patella[J]. Journal of Clinical Medicine in Practice, 2019, 23(23): 95-97. DOI: 10.7619/jcmp.201923029
    [5]WANG Tao, SHI Chang′an, ZHANG Wensheng, LIU Shiping, PANG Jun, GAO Yanwei, LIU Yabo. Effect of anterior cruciate ligament reconstructioncombined with anterior lateral ligament reconstruction on treating anterior cruciate ligament injury with high-grade pivot-shift[J]. Journal of Clinical Medicine in Practice, 2019, 23(11): 86-89. DOI: 10.7619/jcmp.201911024
    [6]WU Xie, ZHANG Lijuan, YU Hong. Effect of target management in functional exercise management after cruciate ligament reconstruction[J]. Journal of Clinical Medicine in Practice, 2019, (6): 66-69. DOI: 10.7619/jcmp.201906017
    [8]DAI Chong-hua, MA Bin. Dynamic fixation of anchors with line for sternoclavicular joint dislocation[J]. Journal of Clinical Medicine in Practice, 2011, (24): 80-82. DOI: 10.3969/j.issn.1672-2353.2011.24.028
    [9]YU Xiao-yang. Surgery coordination of arthroscopic anterior cruciate ligament reconstruction[J]. Journal of Clinical Medicine in Practice, 2011, (14): 93-95. DOI: 10.3969/j.issn.1672-2353.2011.14.041

Catalog

    Get Citation
    PDF
    XML
    Article views (427) PDF downloads (38) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return