Research progress in animal model construction of Graves disease

MAO Jingjing; XIANG Pingping; LIU Chao

doi:10.7619/jcmp.20201887

Journal of Clinical Medicine in Practice > 2021 > 25(9): 113-116, 122. > DOI: 10.7619/jcmp.20201887

MAO Jingjing, XIANG Pingping, LIU Chao. Research progress in animal model construction of Graves disease[J]. Journal of Clinical Medicine in Practice, 2021, 25(9): 113-116, 122. DOI: 10.7619/jcmp.20201887

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Research progress in animal model construction of Graves disease

MAO Jingjing¹,
XIANG Pingping^{1, 2},
LIU Chao^{1, 2, ,}

1.
Endocrine and Metabolic Disease Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210028
2.
Department of Endocrine, Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, Jiangsu, 210028

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Received Date: December 29, 2020
Available Online: May 20, 2021
Published Date: May 14, 2021

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Abstract

Abstract

Graves disease (GD) is an organ-specific autoimmune disease. At present, there are many difficulties in the treatment of GD, including the long course of drug treatment, high recurrence rate and low remission rate. GD animal model is an important tool to study the etiology, pathogenesis and prevention of GD. In recent years, a variety of effective modeling methods have been developed by changing modeling materials, changing administration routes, time and frequency, and adjusting the strain of modeling animals. In this paper, the status quo and research progress of GD model construction were reviewed.
- Graves disease,
- mice,
- model,
- pathogenesis

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References

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