Value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging combined with apparent diffusion coefficient value in evaluating the efficacy of synchronous radiotherapy and chemotherapy in cervical cancer patients

Objective To evaluate the value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCM-MRI)combined with apparent diffusion coefficient(ADC)value in evaluating the efficacy of synchronous radiotherapy and chemotherapy in patients with cervical cancer. Methods A total of 88 cervical cancer patients were selected, and underwent synchronous radiotherapy and chemotherapy, and DCE-MRI examination was carried out before and after treatment. Quantitative parameters of tumor DCE-MRI before and after treatment were measured and analyzed, and ADC values were observed. Results The tumor volume after cervical cancer treatment was significantly smaller than treatment before(P<0.05), ADC value after treatment was significantly higher than treatment before(P<0.05). After treatment, volume transfer coefficient(K_trans)and extravascular extracellular space volume fraction(V_e)of contrast agent leakage from plasma to extracellular spaces in patients with cervical cancer were significantly higher than those before treatment(P<0.05), while rate constant between extravascular extracellular space and blood plasma(K_ep)and fractional blood plasma volume(V_p)showed no significant differences compared to pre-treatment(P>0.05). Conclusion Quantitative parameters of DCM-MRI combined with ADC value can better evaluate the effect of synchronous radiotherapy and chemotherapy of cervical cancer, which can be used as - a routine examination to evaluate the efficacy of radiotherapy and chemotherapy of cervical cancer.