GUI Zhaohua, WU Jing, LI Xiaojie, YAN Hong. Expression of bone morphogenetic protein 9 and insulin-like growth factor-1 in different molecular subtypes of breast cancer and their correlations with clinical features[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 1-5, 10. DOI: 10.7619/jcmp.20210079
Citation: GUI Zhaohua, WU Jing, LI Xiaojie, YAN Hong. Expression of bone morphogenetic protein 9 and insulin-like growth factor-1 in different molecular subtypes of breast cancer and their correlations with clinical features[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 1-5, 10. DOI: 10.7619/jcmp.20210079

Expression of bone morphogenetic protein 9 and insulin-like growth factor-1 in different molecular subtypes of breast cancer and their correlations with clinical features

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  • Received Date: January 04, 2021
  • Available Online: April 29, 2021
  • Published Date: April 27, 2021
  •   Objective  To explore the expression of bone morphogenetic protein 9 (BMP-9)and insulin-like growth factor-1(IGF-1) in different molecular subtypes of breast cancer and their correlations with clinical features.
      Methods  A total of 98 breast cancer patients were divided into Luminal A type group (n=23), Luminal B type group (n=26), HER-2 overexpression type group (n=24), Basal-like type group (n=25) according to different molecular subtypes of breast cancer. The expression levels of BMP-9 and IGF-1 of four groups were compared, and the relationships between the expression levels of BMP-9 as well as IGF-1 and clinical signs were analyzed.
      Results  In 98 cases of breast cancer, BMP-9 was negatively expressed in 36 cases and positively expressed in 62 cases. BMP-9 mRNA level and BMP-9 protein positive rate in the HER-2 overexpression type group and the Basal-like type group were significantly lower than those in the Luminal A type group and the Luminal B type group, and the Luminal B type group was significantly lower than that in the Luminal A type group (P < 0.05). In 98 cases of breast cancer, IGF-1 was negatively expressed in 36 cases and positively expressed in 62 cases. IGF-1 mRNA level and IGF-1 protein positive rate in the HER-2 overexpression type group and the Basal-like type group were significantly higher than those in the Luminal A and Luminal B type groups, and the Luminal B type group was significantly higher than that in the Luminal A type group (P < 0.05). The expression of BMP-9 was negatively correlated with tumor diameter, the number of lymph node metastasis and TNM staging; the expression of IGF-1 was positively correlated with tumor diameter, the number of lymph node metastasis and TNM staging.
      Conclusion  The expressions of BMP-9 and IGF-1 are related to the clinical molecular subtypes of breast cancer patients. In clinical practice, BMP-9 and IGF-1 can be included in the detection of breast cancer to predict the clinical treatment effect of patients.
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