Expression of bone morphogenetic protein 9 and insulin-like growth factor-1 in different molecular subtypes of breast cancer and their correlations with clinical features

GUI Zhaohua; WU Jing; LI Xiaojie; YAN Hong

doi:10.7619/jcmp.20210079

Journal of Clinical Medicine in Practice > 2021 > 25(8): 1-5, 10. > DOI: 10.7619/jcmp.20210079

GUI Zhaohua, WU Jing, LI Xiaojie, YAN Hong. Expression of bone morphogenetic protein 9 and insulin-like growth factor-1 in different molecular subtypes of breast cancer and their correlations with clinical features[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 1-5, 10. DOI: 10.7619/jcmp.20210079

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Expression of bone morphogenetic protein 9 and insulin-like growth factor-1 in different molecular subtypes of breast cancer and their correlations with clinical features

GUI Zhaohua^{1, 2},
WU Jing^{1, 2},
LI Xiaojie^{1, 2},
YAN Hong^{1, 2, ,}

1.
Clinical Pathology Centre, First Affiliated Hospital of University of Science and Techndogy of China, Hefei, Anhui, 230001
2.
Department of Pathology, West Division of First Affiliated Hospital of University of Science and Techndogy of China, Anhui Provincial Cancer Hospital, Hefei, Anhui, 230001

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Received Date: January 04, 2021
Available Online: April 29, 2021
Published Date: April 27, 2021

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Abstract

Abstract

Objective To explore the expression of bone morphogenetic protein 9 (BMP-9)and insulin-like growth factor-1(IGF-1) in different molecular subtypes of breast cancer and their correlations with clinical features.
Methods A total of 98 breast cancer patients were divided into Luminal A type group (n=23), Luminal B type group (n=26), HER-2 overexpression type group (n=24), Basal-like type group (n=25) according to different molecular subtypes of breast cancer. The expression levels of BMP-9 and IGF-1 of four groups were compared, and the relationships between the expression levels of BMP-9 as well as IGF-1 and clinical signs were analyzed.
Results In 98 cases of breast cancer, BMP-9 was negatively expressed in 36 cases and positively expressed in 62 cases. BMP-9 mRNA level and BMP-9 protein positive rate in the HER-2 overexpression type group and the Basal-like type group were significantly lower than those in the Luminal A type group and the Luminal B type group, and the Luminal B type group was significantly lower than that in the Luminal A type group (P < 0.05). In 98 cases of breast cancer, IGF-1 was negatively expressed in 36 cases and positively expressed in 62 cases. IGF-1 mRNA level and IGF-1 protein positive rate in the HER-2 overexpression type group and the Basal-like type group were significantly higher than those in the Luminal A and Luminal B type groups, and the Luminal B type group was significantly higher than that in the Luminal A type group (P < 0.05). The expression of BMP-9 was negatively correlated with tumor diameter, the number of lymph node metastasis and TNM staging; the expression of IGF-1 was positively correlated with tumor diameter, the number of lymph node metastasis and TNM staging.
Conclusion The expressions of BMP-9 and IGF-1 are related to the clinical molecular subtypes of breast cancer patients. In clinical practice, BMP-9 and IGF-1 can be included in the detection of breast cancer to predict the clinical treatment effect of patients.
- bone morphogenetic protein 9,
- insulin-like growth factor-1,
- molecular subtypes,
- breast cancer,
- correlation research

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