Value of combined detection of multiple tumor markers in the diagnosis of non-small cell lung cancer

YAN Fei; MA Yanning; SONG Yan; LIU Xuekai

doi:10.7619/jcmp.20210120

Journal of Clinical Medicine in Practice > 2021 > 25(9): 14-17. > DOI: 10.7619/jcmp.20210120

YAN Fei, MA Yanning, SONG Yan, LIU Xuekai. Value of combined detection of multiple tumor markers in the diagnosis of non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(9): 14-17. DOI: 10.7619/jcmp.20210120

Citation:

PDF (538 KB)

Value of combined detection of multiple tumor markers in the diagnosis of non-small cell lung cancer

1.
Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, 100049
2.
Department of Laboratory, General Hospital of People's Liberation Army, Beijing, 100039

More Information

Received Date: January 06, 2021
Available Online: May 20, 2021
Published Date: May 14, 2021

Graphical Abstract

Abstract

Abstract

Objective To investigate the value of combined detection of folate receptor-positive circulating tumor cells (FR⁺-CTCs), neuronal enolase (NSE) and cytokeratin 19 fragment (CYFRA21-1) in diagnosis of non-small cell lung cancer (NSCLC).
Methods From January 2019 to August 2020, 150 patients with NSCLC were selected as NSCLC group, 100 patients with benign pulmonary lesions were selected as benign lesion group, and 100 healthy people in physical examinations were selected as control group. The levels of FR⁺-CTCs, NSE and CYFRA21-1 were compared among the three groups. The diagnostic efficacies of one indicator and combined detection were analyzed by receiver operating characteristic (ROC) curve.
Results The levels of FR⁺-CTCs, NSE and CYFRA21-1 in the NSCLC group were significantly higher than those in the benign lesion group and control group, and the levels of FR⁺-CTCs, NSE and CYFRA21-1 in the benign lesion group were significantly higher than those in the control group (P < 0.05). In the NSCLC patients with TNM stage Ⅰ and Ⅱ, the positive rate of FR⁺-CTCs was significantly higher than that of NSE and CYFRA21-1 (P < 0.05). The clinicopathological features of 150 patients with NSCLC were analyzed, and the levels of FR⁺-CTCs, NSE and CYFRA21-1 in patients with TNM stage Ⅲ and IV, squamous cell carcinoma, low differentiation and lymph node metastasis were significantly higher than those in patients with TNM stage Ⅰ and Ⅱ, adenocarcinoma, high differentiation and no lymph node metastasis (P < 0.05). ROC curve analysis showed that the area under curve (AUC), sensitivity and specificity of combined detection were 0.938, 90.1% and 84.6% respectively, which were significantly higher than those of single detection (P < 0.05).
Conclusion FR⁺-CTCs has a high detection rate in the early stage of NSCLC. Combined detection of FR⁺-CTCs, NSE and CYFRA21-1 can further improve the diagnostic efficiency, which is of great significance for the early diagnosis of NSCLC.
- non-small cell lung cancer,
- folate receptor-positive circulating tumor cells,
- neuronal enolase,
- cytokeratin 19 fragment

FullText(HTML)

References (14)

References

[1]	BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. doi: 10.3322/caac.21492
[2]	SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1): 7-30. doi: 10.3322/caac.21590
[3]	WANG L, ZHAO D Z, QIN K, et al. Effect and biomarker of Nivolumab for non-small-cell lung cancer[J]. Biomedecine Pharmacother, 2019, 117: 109199. doi: 10.1016/j.biopha.2019.109199
[4]	CHENG B, XIONG S, LI C C, et al. An annual review of the remarkable advances in lung cancer clinical research in 2019[J]. J Thorac Dis, 2020, 12(3): 1056-1069. doi: 10.21037/jtd.2020.03.11
[5]	CHEN Z Q, HUANG L S, ZHU B. Assessment of seven clinical tumor markers in diagnosis of non-small-cell lung cancer[J]. Dis Markers, 2018, 2018: 9845123. http://www.researchgate.net/publication/329578407_Assessment_of_Seven_Clinical_Tumor_Markers_in_Diagnosis_of_Non-Small-Cell_Lung_Cancer/download
[6]	李倩, 郑琪, 马婕群, 等. 叶酸受体阳性循环肿瘤细胞检测的临床研究进展[J]. 标记免疫分析与临床, 2020, 27(2): 356-360. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY202002036.htm
[7]	LIU H. Updates of the NCCN guidelines for small cell lung cancer[J]. 肿瘤学与转化医学: 英文版, 2018, 4(2): 81-83. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF201905012.htm
[8]	杨龙海, 叶波, 魏星, 等. 最新国际肺癌TNM分期标准(第8版)修订稿解读[J]. 中国医刊, 2016, 51(9): 22-25. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYI201609007.htm
[9]	王春梅, 高艳丽, 尹丽霞. 非小细胞肺癌放射治疗研究进展[J]. 中华肿瘤防治杂志, 2017, 24(10): 720-724. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL201710013.htm
[10]	RZECHONEK A, BŁASIAK P, MUSZCZYÑSKA-BERNHARD B, et al. Metachronous lung cancer: clinical characteristics and effects of surgical treatment[J]. Adv Exp Med Biol, 2018, 1039: 9-17. doi: 10.1007%2F5584_2017_82
[11]	CHEN L J, PENG M, LI N, et al. Combined use of EpCAM and FRα enables the high-efficiency capture of circulating tumor cells in non-small cell lung cancer[J]. Sci Rep, 2018, 8(1): 1188. doi: 10.1038/s41598-018-19391-1
[12]	盛俊卿, 李卫星, 贾祯, 等. 多层螺旋CT灌注成像联合血清CYFRA21-1、CEA、NSE对周围型非小细胞肺癌的诊断价值[J]. 解放军医学杂志, 2020, 45(5): 542-546. https://www.cnki.com.cn/Article/CJFDTOTAL-JFJY202005015.htm
[13]	刘亚杰, 马晓波. 肿瘤标志物GSTP1、CYFRA21-1及SCC-Ag对非小细胞肺癌的预后评估价值[J]. 中国现代医学杂志, 2020, 30(14): 42-46. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXDY202014009.htm
[14]	潘世泽, 汪巍, 方一凡, 等. 叶酸受体阳性循环肿瘤细胞检测对早期肺癌的诊断效能[J]. 山东医药, 2017, 57(47): 69-72. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201747021.htm

[1]	TAO Rui, HAN Wenchao, Ding Tianxiang, FAN Chongshan. Circular RNA_0032131 regulates the proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting microRNA-145-5p[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 53-57, 62. DOI: 10.7619/jcmp.20240212
[2]	QIU Shu, LU Hongmei, ZHOU Jie. Expression and clinicopathological significance of ultra-conserved RNA-339 in cervical squamous cell carcinoma[J]. Journal of Clinical Medicine in Practice, 2023, 27(11): 32-37,42. DOI: 10.7619/jcmp.20230723
[3]	CHEN Yanrong, LIU Yan, WANG Shan, ZHANG Jing. Expression characteristics and detection value of histamine, soluble myeloid cell trigger receptor-1, microribonuclease-145 and high-sensitivity C-reactive protein in patients with chronic obstructive pulmonary disease and coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 1-5. DOI: 10.7619/jcmp.20223161
[4]	HU Zhipeng, YE Zhi, ZHANG Qingxin. Establishment of a prediction model of lymph node metastasis in patients with non-small cell lung cancer at high altitude areas based on energy spectrum CT parameters and clinicopathological factors[J]. Journal of Clinical Medicine in Practice, 2022, 26(18): 6-10. DOI: 10.7619/jcmp.20220739
[5]	LIU Peifa, HOU Wenyu, JIAN Yanbing. Expression levels of microRNA-485-3p and Xklp2 target protein in breast cancer tissues and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 29-34. DOI: 10.7619/jcmp.20212629
[6]	CHEN Jingzhi, MA Lili, FENG Yanyu. Expressions of circulating tumor cells, microribonucleic acid 1246, carbohydrate antigen 153 in breast cancer patients and their relationships with different clinicopathological features and prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 17-20, 25. DOI: 10.7619/jcmp.20211886
[7]	ZHANG Nana, SHEN Bin, CHEN Xi, LIANG Wenlong, ZHANG Jianguo. Research progress of microRNAs in breast cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(4): 106-110, 115. DOI: 10.7619/jcmp.20201506
[8]	YAN Yun, GUO Yulian, WANG Chenghai. Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
[9]	DENG Hui, LI Xinyu, WU Yandan, WANG Chenghai. Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance[J]. Journal of Clinical Medicine in Practice, 2019, 23(9): 5-8. DOI: 10.7619/jcmp.201909002
[10]	WANG Haigang, XIE Hongmei, HAN Xue, ZHANG Lixian, ZHAO Wenzeng. Expression of uH2B in primary adenocarcinoma of the colon and its relationship with clinicopathological parameters[J]. Journal of Clinical Medicine in Practice, 2017, (9): 99-102. DOI: 10.7619/jcmp.201709025

Cited By

Get Citation

PDF

XML

Article views (407) PDF downloads (18)

Turn off MathJax

Article Contents

Abstract

References

Value of combined detection of multiple tumor markers in the diagnosis of non-small cell lung cancer

Abstract

References

Related Articles

Catalog

Value of combined detection of multiple tumor markers in the diagnosis of non-small cell lung cancer

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content