Value of forkhead box protein 3 and interleukin-10 combined with clinical features in predicting recurrence of male patients with intra-anal condyloma acuminatum

DUAN Baoxue; WU Yaoqun

doi:10.7619/jcmp.20210157

Journal of Clinical Medicine in Practice > 2021 > 25(9): 65-69. > DOI: 10.7619/jcmp.20210157

DUAN Baoxue, WU Yaoqun. Value of forkhead box protein 3 and interleukin-10 combined with clinical features in predicting recurrence of male patients with intra-anal condyloma acuminatum[J]. Journal of Clinical Medicine in Practice, 2021, 25(9): 65-69. DOI: 10.7619/jcmp.20210157

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Value of forkhead box protein 3 and interleukin-10 combined with clinical features in predicting recurrence of male patients with intra-anal condyloma acuminatum

DUAN Baoxue,
WU Yaoqun^,

Department of Dermatology, Xiangyang City First People's Hospital of Hubei Province, Xiangyang, Hubei, 441000

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Received Date: January 07, 2021
Available Online: May 20, 2021
Published Date: May 14, 2021

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Abstract

Abstract

Objective To analyze the value of forkhead box protein 3 (Foxp3), interleukin-10 (IL-10) combined with clinical features in predicting the recurrence of male patients with intra-anal condyloma acuminatum.
Methods The clinical materials of 160 male patients with intra-anal condyloma acuminatum were retrospectively analyzed. According to the recurrence conditions, they were divided into recurrence group (n=98) and non-recurrence group (n=62), and the clinical features as well as Foxp3 and IL-10 levels were compared between the two groups. The best cut-off values of Foxp3 and IL-10 were analyzed by receiver operating characteristic (ROC) curve, and the risk factors of recurrence of condyloma acuminatum were analyzed by Logistic regression model.
Results In the recurrence group, the proportions of patients with simple surgical resection, staying up late, drinking, high and mixed types of human papillomavirus and deoxyribonucleic acid (HPV-DNA), other sexually transmitted diseases, wart diameter≥0.5 cm, drug interruption and the levels of Foxp3 and IL-10 were significantly higher than those in the non-recurrence group (P < 0.05). ROC curve analysis showed that the areas under the curve of Foxp3 and IL-10 were 0.881 and 0.910, respectively. Logistic regression analysis showed that Foxp3≥0.195%, IL-10≥394.210 ng/L, simple surgical resection, staying up late, drinking, high and mixed types of HPV-DNA, complicated with other sexually transmitted diseases, wart diameter ≥0.5 cm, drug interruption were risk factors for recurrence of condyloma acuminatum.
Conclusion Foxp3≥0.195%, IL-10≥394.210 ng/L, simple surgical resection, staying up late, drinking, high and mixed types of HPV-DNA, complicated with other sexually transmitted diseases, wart diameter ≥0.5 cm, drug interruption are risk factors for recurrence of patients with condyloma acuminatum.
- condyloma acuminatum,
- forkhead box protein 3,
- human papillomavirus,
- interleukin-10

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[1]	NA K, SUNG J Y, KIM H S. Clinicopathological characteristics of high-grade squamous intraepithelial lesions involving condyloma acuminatum[J]. Anticancer Res, 2018, 38(3): 1767-1774. http://europepmc.org/abstract/MED/29491115
[2]	龙秀荣, 姜锦贵, 耿建祥, 等. 691例女性外阴尖锐湿疣组织HPV感染基因分型的研究[J]. 国际检验医学杂志, 2017, 38(17): 2350-2352. doi: 10.3969/j.issn.1673-4130.2017.17.006
[3]	张莹. 胸腺肽联合5-氨基酮戊酸光动力疗法对尖锐湿疣患者T淋巴细胞亚群水平的改善作用探讨[J]. 中外医学研究, 2019, 17(6): 21-23. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201906010.htm
[4]	黄银浩, 陈永艳, 王宝仁. 尖锐湿疣皮损中Foxp3、IL-10的表达及意义[J]. 遵义医学院学报, 2019, 42(1): 64-66, 70. doi: 10.3969/j.issn.1000-2715.2019.01.012
[5]	中华医学会皮肤性病学分会性病学组, 中国医师协会皮肤科分会性病亚专业委员会. 尖锐湿疣诊疗指南(2014)[J]. 中华皮肤科杂志, 2014, 47(8): 598-599. doi: 10.3760/cma.j.issn.0412-4030.2014.08.020
[6]	黄波, 杜策. 醋酸白试验阳性区二氧化碳激光治疗对尖锐湿疣复发的影响观察[J]. 中国性科学, 2016, 25(2): 79-81. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201602028.htm
[7]	齐铁军, 马婷婷, 孔连委, 等. 尖锐湿疣疣体内TLR9表达水平与免疫应答和细胞凋亡的相关性研究[J]. 临床和实验医学杂志, 2020, 19(3): 296-299. doi: 10.3969/j.issn.1671-4695.2020.03.021
[8]	GALLAY C, MIRANDA E, SCHAEFER S, et al. Human papillomavirus (HPV) contamination of gynaecological equipment[J]. Sex Transm Infect, 2016, 92(1): 19-23. doi: 10.1136/sextrans-2014-051977
[9]	张超, 伍洲炜, 施伟民. 派特灵外涂联合光动力疗法治疗阴茎尖锐湿疣的疗效及对患者局部HPV病毒载量水平的影响[J]. 中国性科学, 2017, 26(11): 68-72. doi: 10.3969/j.issn.1672-1993.2017.11.022
[10]	胡亚民. 研究光动力三阶段治疗尖锐湿疣的临床疗效[J]. 中医临床研究, 2020, 12(9): 55-56. doi: 10.3969/j.issn.1674-7860.2020.09.023
[11]	刘波, 白雪. 男性尖锐湿疣复发的危险因素分析[J]. 中国性科学, 2018, 27(7): 128-130. doi: 10.3969/j.issn.1672-1993.2018.07.038
[12]	王稳, 于善萍, 刘晓虹. 尖锐湿疣患者宫颈HPV分型检测[J]. 中国麻风皮肤病杂志, 2016, 32(5): 307-308. https://www.cnki.com.cn/Article/CJFDTOTAL-MALA201605027.htm
[13]	蔡光辉, 王是. 206例男性尖锐湿疣复发的危险因素分析[J]. 中国性科学, 2019, 28(3): 130-132. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201903040.htm
[14]	周小青, 李静, 赵蕾, 等. 自然杀伤细胞通过树突状细胞调控衣原体肺部感染中Th17/Treg免疫应答平衡[J]. 山东大学学报: 医学版, 2019, 57(4): 15-19. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYB201904003.htm
[15]	宣晓梅, 陈立荣, 林琳, 等. 尖锐湿疣患者外周血淋巴细胞Foxp3与树突状细胞TLR9、IRF-7水平变化特征[J]. 第三军医大学学报, 2019, 41(20): 2012-2016. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201920015.htm
[16]	徐小容, 陈永艳. 尖锐湿疣患者外周血IL-17 IL-23 IL-10和TGF-β表达水平[J]. 中国艾滋病性病, 2018, 24(7): 711-713. https://www.cnki.com.cn/Article/CJFDTOTAL-XBYA201807019.htm
[17]	杨爱琴, 卞坤鹏, 翟伟, 等. 尖锐湿疣患者疣体病变皮损组织中Fas、FasL及Foxp3表达与HPV DNA载量的相关性研究[J]. 中华医院感染学杂志, 2017, 27(6): 1366-1369. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201706045.htm

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Value of forkhead box protein 3 and interleukin-10 combined with clinical features in predicting recurrence of male patients with intra-anal condyloma acuminatum

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