Objective To analyze the relationship between pituitary denoma apoplexy induced nemorrhage and invasiveness of pituitary tumor based on propensity score matching method.
Methods The clinical data of 570 patients with pituitary adenoma was retrospectively analyzed, and the patients were divided into stroke group (100 cases) and non-stroke group (470 cases) according to occurrence of hemorrhage caused by stroke of pituitary adenoma. After eliminating the interfering factors of baseline data by the method of propensity score matching method, the stroke group and the non-stroke group were matched in a 1:1 ratio, and the relationship between hemorrhage caused by stroke and pituitary adenoma invasion was analyzed by conditional Logistic analysis.
Results Before matching, there were statistically significant differences in gender, age and Knosp grading between the two groups (P < 0.05). After matching, after adjusting for confounding factors, there was no significant difference in baseline data between the two groups (P>0.05). The results of binary Logistic regression analysis showed that hemorrhage after pituitary adenoma stroke had significant correlation with the invasion of pituitary adenoma (P=0.008), but no correlation with the size of pituitary adenoma (P=0.746). Among different Knosp grading, Knosp grade 3 was a risk factor for pituitary adenoma stroke (P=0.019).
Conclusion Pituitary tumors with invasion and those in Knosp 3 grading are more prone to present hemorrhage. The size of the pituitary tumor does not affect apoplexy. Therefore, pituitary tumor patients with cavernous sinus invasion should accept the treatment as early as possible regardless of the size of the tumor.
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