Analysis in contrast-enhanced ultrasound features of breast cancer for different Luminal types

GONG Haiyan; WANG Hui; DENG Jing; ZHA Hailing; ZHOU Wenbin; LI Cuiying

doi:10.7619/jcmp.20210737

Journal of Clinical Medicine in Practice > 2021 > 25(13): 19-23. > DOI: 10.7619/jcmp.20210737

GONG Haiyan, WANG Hui, DENG Jing, ZHA Hailing, ZHOU Wenbin, LI Cuiying. Analysis in contrast-enhanced ultrasound features of breast cancer for different Luminal types[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 19-23. DOI: 10.7619/jcmp.20210737

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Analysis in contrast-enhanced ultrasound features of breast cancer for different Luminal types

1.
Department of Ultrasound Diagnosis, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029
2.
Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029

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Received Date: April 02, 2021
Available Online: July 07, 2021
Published Date: July 14, 2021

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Abstract

Abstract

Objective To explore the features of contrast-enhanced ultrasound of breast cancer for different Luminal types.
Methods A total of 98 patients with Luminal breast cancer were examined by preoperative contrast-enhanced ultrasound. The relationships between the characteristics of imaging and molecular subtypes were analyzed.
Results Luminal A type and Luminal B type had statistical significance in perfusion defect (P=0.043). Compared with Luminal A type, it was found that perfusion defect was more frequently seen in Luminal B type. They showed the following similar characteristics: high enhancement, overall enhancement, non-uniform distribution of contrast agent, centrality, clear boundary, irregular shape, no penetration or distortion of blood vessels, no perfusion defect, no expansion of scope, slow backward. There were significant differences in Peak intensity (Peak), Area Under Curve (AUC) and Peak difference between Luminal A type and Luminal B type (P < 0.05). The Peak, Peak difference and AUC of Luminal B type were significantly higher than Luminal A type.
Conclusion There are differences in the characteristics and quantitative parameters between Luminal A type and Luminal B type, which can be used to provide imaging information for preoperative prediction of breast cancer for molecular subtypes.
- breast carcinoma,
- contrast-enhanced ultrasound,
- molecular subtypes,
- Peak intensity

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References (20)

References

[1]	赵菲, 范林军. 2014年美国临床肿瘤学会指南更新: 激素受体阳性乳腺癌的辅助内分泌治疗[J]. 中华乳腺病杂志: 电子版, 2014, 8(5): 63-64. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHRD200806015.htm
[2]	陆春燕, 吕凤菊, 陈浩华, 等. 浸润性乳腺癌分子亚型患者的临床特征及预后研究[J]. 实用医学杂志, 2012, 28(5): 765-767. doi: 10.3969/j.issn.1006-5725.2012.05.030
[3]	刘钟芬, 陈创, 姚晓莉, 等. 乳腺癌不同分子分型的临床病理特点及预后分析[J]. 中华医学杂志, 2016, 96(22): 1733-1737. doi: 10.3760/cma.j.issn.0376-2491.2016.22.004
[4]	李杰宝, 喻晓程, 田野. 乳腺癌分子分型与临床病理参数的关系及预后[J]. 中华实验外科杂志, 2018, 35(6): 1027-1029. doi: 10.3760/cma.j.issn.1001-9030.2018.06.010
[5]	KIROVA Y M, CARROLL S, FOURQUET A, et al. The St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2017: the point of view of an International Panel of Experts in Radiation Oncology[J]. Ann Oncol, 2018, 29(1): 280-281. doi: 10.1093/annonc/mdx537
[6]	康宇娟, 刘思, 宋健, 等. 乳腺癌分子分型的研究进展[J]. 中华实验外科杂志, 2016, 33(4): 1158-1160. doi: 10.3760/cma.j.issn.1001-9030.2016.04.094
[7]	郝丽莉, 陈计赏, 李江, 等. Luminal A型和Luminal B型乳腺癌患者的临床特征和预后[J]. 包头医学院学报, 2017, 33(7): 69-70. https://www.cnki.com.cn/Article/CJFDTOTAL-BTYX201707028.htm
[8]	MENDELSON E B, BÖHM-VÉLEZ M, BERG W A, et al. ACR BI-RADS ATLAS-BREAST ULTRASOND[M]. Reston, VA: American College of Radiology, 2013: 1-153.
[9]	高军喜, 马方婧, 杨磊, 等. 不同分子亚型乳腺癌超声造影特征及定量参数对比研究[J]. 中国临床医学影像杂志, 2019, 30(4): 261-266. https://www.cnki.com.cn/Article/CJFDTOTAL-LYYX201904011.htm
[10]	CALIL L N, IGANSI C N, MEURER L, et al. Chlamydia trachomatis and human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and neoplastic lesions[J]. Braz J Infect Dis, 2011, 15(2): 126-131. http://europepmc.org/abstract/MED/21503398
[11]	CEAUSU R A, CIMPEAN A M, GAJE P, et al. CD105/Ki67 double immunostaining expression in liver metastasis from colon carcinoma[J]. Rom J Morphol Embryol, 2011, 52(2): 613-616. http://www.ncbi.nlm.nih.gov/pubmed/21655651
[12]	METZ S, DALDRUP-LINK H E, RICHTER T, et al. Detection and quantification of breast tumor necrosis with MR imaging: value of the necrosis-avid contrast agent Gadophrin-3[J]. Acad Radiol, 2003, 10(5): 484-490. doi: 10.1016/S1076-6332(03)80056-9
[13]	沈若霞, 杨丽春, 罗晓茂, 等. 基于中国多中心研究数据的乳腺良恶性病灶超声造影定性特征的回顾性研究[J]. 中国医学影像学杂志, 2018, 26(12): 885-889. doi: 10.3969/j.issn.1005-5185.2018.12.002
[14]	孙敏, 胡晓丹, 杨昭晖, 等. 超声造影特征及定量参数鉴别诊断乳腺良恶性结节的临床价值[J]. 临床超声医学杂志, 2020, 22(6): 444-447. doi: 10.3969/j.issn.1008-6978.2020.06.013
[15]	康佳, 吴桐, 张蕾, 等. 不同分子分型乳腺癌的多模态超声特征和临床病理对照研究[J]. 中华超声影像学杂志, 2020, 29(4): 330-336. doi: 10.3760/cma.j.cn131148-20190926-00591
[16]	LIANG XY, LI ZY, ZHANG L, et al. Application of contrast-enhanced ultrasound in the differential diagnosis of different molecular subtypes of breast cancer[J]. Ultrason Imaging, 2020, 42(6): 261-270. doi: 10.1177/0161734620959780
[17]	任秀昀, 高农, 潘宜鹏, 等. 超声造影定量参数在评估脑死亡器官捐献供肝中的应用价值[J]. 器官移植, 2020, 11(5): 610-613. doi: 10.3969/j.issn.1674-7445.2020.05.014
[18]	GARCÍA FERNÁNDEZ A, CHABRERA C, GARCÍA FONT M, et al. Differential patterns of recurrence and specific survival between luminal A and luminal B breast cancer according to recent changes in the 2013 St Gallen immunohistochemical classification[J]. Clin Transl Oncol, 2015, 17(3): 238-246. doi: 10.1007/s12094-014-1220-8
[19]	吴芳, 成静, 马婷, 等. 不同分子分型乳腺癌的超声造影特征分析[J]. 临床超声医学杂志, 2019, 21(1): 1-4. doi: 10.3969/j.issn.1008-6978.2019.01.001
[20]	沈建红, 林勇, 沈蔷, 等. 应用ROC曲线分析超声造影对乳腺癌的诊断价值[J]. 广东医学, 2009, 30(3): 396-397. doi: 10.3969/j.issn.1001-9448.2009.03.029

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