Analysis in contrast-enhanced ultrasound features of breast cancer for different Luminal types

  Objective  To explore the features of contrast-enhanced ultrasound of breast cancer for different Luminal types.

  Methods  A total of 98 patients with Luminal breast cancer were examined by preoperative contrast-enhanced ultrasound. The relationships between the characteristics of imaging and molecular subtypes were analyzed.

  Results  Luminal A type and Luminal B type had statistical significance in perfusion defect (P=0.043). Compared with Luminal A type, it was found that perfusion defect was more frequently seen in Luminal B type. They showed the following similar characteristics: high enhancement, overall enhancement, non-uniform distribution of contrast agent, centrality, clear boundary, irregular shape, no penetration or distortion of blood vessels, no perfusion defect, no expansion of scope, slow backward. There were significant differences in Peak intensity (Peak), Area Under Curve (AUC) and Peak difference between Luminal A type and Luminal B type (P < 0.05). The Peak, Peak difference and AUC of Luminal B type were significantly higher than Luminal A type.

  Conclusion  There are differences in the characteristics and quantitative parameters between Luminal A type and Luminal B type, which can be used to provide imaging information for preoperative prediction of breast cancer for molecular subtypes.