Clinicopathological observation of <i>Helicobacter pylori</i> infection in elderly patients with colorectal adenoma

LI Jiang; QIU Yan; WANG Ting; WANG Dan; WANG Li

doi:10.7619/jcmp.20210746

Journal of Clinical Medicine in Practice > 2021 > 25(13): 10-14. > DOI: 10.7619/jcmp.20210746

LI Jiang, QIU Yan, WANG Ting, WANG Dan, WANG Li. Clinicopathological observation of Helicobacter pylori infection in elderly patients with colorectal adenoma[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 10-14. DOI: 10.7619/jcmp.20210746

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Clinicopathological observation of Helicobacter pylori infection in elderly patients with colorectal adenoma

LI Jiang^{1, 2},
QIU Yan¹,
WANG Ting¹,
WANG Dan¹,
WANG Li^2, ,

1.
Department of Pathology, Provincial Government Hospital of Jiangsu Province, Nanjing, Jiangsu, 210024
2.
Jiangsu Health Vocational College, Nanjing, Jiangsu, 211800

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Received Date: February 22, 2021
Available Online: July 07, 2021
Published Date: July 14, 2021

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Abstract

Abstract

Objective To investigate the relationship between Helicobacter pylori (Hp) infection and clinicopathological parameters in elderly patients with colorectal adenoma.
Methods A total of 204 elderly patients with colorectal adenoma were included in the colorectal adenoma group and 110 were selected in the control group. Clinical data of the two groups was retrospectively analyzed. The relationships between Hp infection and clinicopathological parameters of colorectal adenoma were observed and analyzed.
Results The positive rate of Hp infection in colorectal adenoma group was 54.9%, which was significantly higher than 42.7% in the control group (P < 0.05). In the colorectal adenoma group, the Hp positive infection rate of patients with body mass index (BMI) ≥ 25 kg/m² was significantly higher than that of patients with BMI < 25 kg/m², the positive Hp infection rate of patients with diabetes history was significantly higher than that of those without, and the Hp positive infection rate of patients with smoking history was significantly higher than that of those without (P < 0.05). Hp positive infection rate in patients with proximal adenoma was significantly lower than that in those with distal adenoma, and Hp positive infection rate in patients with low-grade intraepithelial neoplasia was significantly lower than that in those with high-grade intraepithelial neoplasia (P < 0.05).
Conclusion Hp infection in elderly colorectal adenoma patients may be correlated with BMI, history of diabetes mellitus, smoking history, location of adenoma and degree of intraepithelial neoplasia.
- Helicobacter pylori infection,
- colorectal adenoma,
- the elderly,
- flora disequilibrium

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