Objective To investigate the correlations between serum brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), creatine kinase isoenzyme (CK-MB) and short-term prognosis in patients with acute myocardial infarction after percutaneous coronary intervention (PCI).
Methods A total of 182 patients with acute myocardial infarction who underwent PCI were selected as the study subjects, and were divided into poor prognosis group (n=58) and good prognosis group (n=124) according to the occurrence of adverse cardiovascular events within three months after the operation. The serum levels of BNP, hs-CRP and CK-MB were detected by enzyme-linked immunosorbent assay (ELISA); the serum BNP, hs-CRP and CK-MB levels in patients with poor prognosis were analyzed; the predictive value of serum BNP, hs-CRP, CK-MB levels on the poor prognosis of acute myocardial infarction after PCI were analyzed; the factors affecting the poor prognosis of patients with PCI were analyzed.
Results The serum levels of BNP, hs-CRP and CK-MB in poor prognosis group were significantly higher than those in good prognosis group (P < 0.05). Serum BNP was positively correlated with hs-CRP and CK-MB levels in patients with poor prognosis (r=0.527, P < 0.05; r=0.541, P < 0.05), there was a positive correlation between CK-MB and hs-CRP (r=0.511, P < 0.05). The area under the curve (AUC) of serum BNP, hs-CRP, CK-MB alone and their combination in predicting poor prognosis after PCI were 0.872, 0.763, 0.921, 0.949, respectively, the specificity were 87.9%, 82.3%, 94.4%, 93.5%, respectively, and the sensitivity was 74.1%, 63.8%, 81.0% and 87.9%, respectively. NP and CK-MB were independent risk factors for poor prognosis in patients with acute myocardial infarction after PCI (P < 0.05).
Conclusion Serum BNP, hs-CRP and CK-MB have a certain predictive effect on the poor prognosis of patients with acute myocardial infarction after PCI.
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