Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer

YANG Mei; PEI Bo; CHEN Dian

doi:10.7619/jcmp.20211191

Journal of Clinical Medicine in Practice > 2021 > 25(22): 35-37. > DOI: 10.7619/jcmp.20211191

YANG Mei, PEI Bo, CHEN Dian. Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 35-37. DOI: 10.7619/jcmp.20211191

Citation:

PDF (474 KB)

Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer

1.
Medical College, Hubei Minzu University, Enshi, Hubei, 445000
2.
Oncology Department, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture of Hubei Minzu University, Enshi, Hubei, 445000

More Information

Received Date: March 18, 2021
Available Online: December 03, 2021
Published Date: November 27, 2021

Graphical Abstract

Abstract

Abstract

Objective To observe the short-term efficacy of selenium yeast combined with concurrent chemoradiotherapy for patients with stage ⅡB cervical cancer.
Methods One hundred and three cervical cancer patients were included and randomly divided into experimental group (n=50) and control group (n=53). The experimental group was given oral selenium yeast, while control group was given placebo, and both groups received concurrent chemoradiotherapy with cisplatin. After radiotherapy, the tumor lesion, myelosuppression, liver and kidney impairment were assessed by laboratory indicators and imaging results.
Results There were statistically significant difference in total effective rate between the two groups (P < 0.05). There was no significant difference in the incidence of bone marrow suppression, kidney injury, liver injury and other toxic and side effects between the experimental group and the control group (P>0.05).
Conclusion The short-term efficacy of selenium yeast tablets during concurrent chemoradiotherapy in patients with advanced cervical cancer is better than that of chemoradiotherapy alone.
- selenium,
- cervical cancer,
- concurrent chemoradiotherapy,
- short-term efficacy,
- toxic and side effects

FullText(HTML)

References (17)

References

[1]	BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. doi: 10.3322/caac.21492
[2]	王颖杰, 朱启峰, 陈友山. 同步放化疗与序贯放化疗法治疗局部晚期非小细胞肺癌的近期疗效和不良反应比较[J]. 当代医学, 2021, 27(4): 79-81. doi: 10.3969/j.issn.1009-4393.2021.04.031
[3]	郝敏, 张娜. 宫颈癌新辅助化疗与同步放化疗[J]. 中国实用妇科与产科, 2010, 26(3): 168-174. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF201003007.htm
[4]	LIU Y, LI W, GUO M, et al. Protective role of selenium compounds on the proliferation, apoptosis, and angiogenesis of a canine breast cancer cell line[J]. Biological Trace Element Research, 2016, 169(1): 86-93. doi: 10.1007/s12011-015-0387-3
[5]	向芳, 李胜, 郝莲, 等. 2003-2017年中国女性宫颈癌死亡率趋势分析[J]. 卫生经济研究, 2020, 37(5): 23-27.
[6]	敖梅红, 邓旭情, 熊艳, 等. 7 051例宫颈癌患者发病趋势分析[J]. 现代妇产科进展, 2018, 27(1): 48-50. https://www.cnki.com.cn/Article/CJFDTOTAL-XDFC201801012.htm
[7]	熊慧, 刘平, 邹文, 等. 局部中晚期宫颈癌同步放化疗临床疗效及预后影响因素分析[J]. 中国全科医学, 2018, 21(17): 2053-2058. doi: 10.3969/j.issn.1007-9572.2017.00.235
[8]	LOBB R J, JACOBSON G M, CURSONS R T, et al. The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells[J]. International Journal of Molecular Sciences, 2018, 19(10): 1-12. http://www.onacademic.com/detail/journal_1000040888411810_d053.html
[9]	BAS E, NAZIROGLU M. Selenium attenuates docetaxel-induced apoptosis and mitochondrial oxidative stress in kidney cells[J]. Anti-Cancer Drugs, 2019, 30(4): 339-346. doi: 10.1097/CAD.0000000000000723
[10]	LUBINSKI J, MARCINIAK W, MUSZYNSKA M, et al. Serum selenium levels predict survival after breast cancer[J]. Breast Cancer Res Treat, 2018, 167(2): 591-598. doi: 10.1007/s10549-017-4525-9
[11]	SOUMYA M, SHRUDHI D, SANTHIYA R, et al. Selenium nanoparticles a potent chemotherapeutic agent and an elucidation of its mechanism[J]. Colloids and Surfaces B: Biointerfaces, 2018, 170: 280-292. doi: 10.1016/j.colsurfb.2018.06.006
[12]	GUO C H, HSIA S, SHIH M Y, et al. Effects of selenium yeast on oxidative stress, growth inhibition, and apoptosis in human breast cancer cells[J]. Int J Med Sci, 2015, 12(9): 748-758. doi: 10.7150/ijms.12177
[13]	QIAN S, XIE L X, LI G B, et al. Radiosensitization effect of selenocystine on HeLa cells in vitro[J]. Precision Radiation Oncology, 2020, 4(1): 4-9. doi: 10.1002/pro6.1085
[14]	FRANCA CAS, NOGUEIRA C R, RAMALHO A, et al. Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy[J]. Annals of Oncology, 2011, 22(5): 1109-1112. doi: 10.1093/annonc/mdq547
[15]	林显敢, 谢德荣, 梁新文, 等. 硒制剂在预防化疗过程中血液毒性的作用[J]. 微量元素与健康研究, 2001, 18(2): 23-24. https://www.cnki.com.cn/Article/CJFDTOTAL-WYJK200102010.htm
[16]	SIEJA K, TALERCZYK M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy[J]. Gynecologic Oncology, 2004, 93(2): 320-327. doi: 10.1016/j.ygyno.2003.12.013
[17]	DUFFIELD-LILLICO A J, DALKIN B L, REID M E, et al. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial[J]. BJU International, 2003, 91(7): 608-612. doi: 10.1046/j.1464-410X.2003.04167.x

[1]	TONG Lingling. Value of detailed nursing in neurosurgery department[J]. Journal of Clinical Medicine in Practice, 2018, (8): 111-113. DOI: 10.7619/jcmp.201808034
[2]	CHEN Xiaohong, HUANG Xia. Effect of comprehensive nursing intervention on the compliance behavior and recurrence rate of patients with lumbar disc herniation[J]. Journal of Clinical Medicine in Practice, 2017, (12): 70-72. DOI: 10.7619/jcmp.201712021
[3]	WANG Changjun, GU Jing. Effect of procedural nursing in treatment of recurrent cervical cancer patients[J]. Journal of Clinical Medicine in Practice, 2017, (10): 109-111,119. DOI: 10.7619/jcmp.201710033
[4]	GUI Yanhua, GUI Chengying, JIN Yingyan. Application effect of nursing intervention on the prevention of postoperative recurrence of bladder cancer by bladder irrigation of hydroxycamptothecine[J]. Journal of Clinical Medicine in Practice, 2017, (8): 110-112,120. DOI: 10.7619/jcmp.201708033
[5]	DAN Dan, ZHANG Li, HUANG Xiujuan, PENG Yinqiong. Effect of comprehensive nursing intervention on the isease cognition and recurrence after lithotripsy in patients with urinary calculi[J]. Journal of Clinical Medicine in Practice, 2016, (20): 89-91. DOI: 10.7619/jcmp.201620028
[6]	FENG Jing. Effect of Objective nursing measures on the emergency nursing quality and nurse-patient disputes[J]. Journal of Clinical Medicine in Practice, 2016, (8): 73-76. DOI: 10.7619/jcmp.201608023
[7]	GUAN Yiyu, XU Shaorong, JI Yunling, WU Lie. Application of clinical nursing pathway in postoperative nursing of lung cancer patients[J]. Journal of Clinical Medicine in Practice, 2016, (4): 47-49. DOI: 10.7619/jcmp.201604015
[8]	HU Liang, SUN Bingwei, XIAO Guixi, YU Ye. Effect of bioactive glass combined with bath therapy on treatment of patients with residual burn wound[J]. Journal of Clinical Medicine in Practice, 2014, (9): 72-75. DOI: 10.7619/jcmp.201409020
[9]	WANG Xiuli, QIN Wenmin, NIE Bo. Comprehensive nursing for patients with hysteroadenomyosis[J]. Journal of Clinical Medicine in Practice, 2013, (8): 99-101. DOI: 10.7619/jcmp.201308037
[10]	YANG Yan. Influence of comprehensive nursing intervention on compliance of medication and recurrence rate in discharged patients with schizophrenia[J]. Journal of Clinical Medicine in Practice, 2013, (8): 55-57. DOI: 10.7619/jcmp.201308021

Cited By

Cited by

Periodical cited type(0)

Other cited types(1)

Get Citation

PDF

XML

Article views (295) PDF downloads (18) Cited by(1)

Turn off MathJax

Article Contents

Abstract

References

Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer

Abstract

References

Related Articles

Cited by

Periodical cited type(0)

Other cited types(1)

Catalog

Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer

Abstract

References

Related Articles

Cited by

Periodical cited type(0)

Other cited types(1)

Catalog

Export File

Citation

Format

Content