Expression of serum factors in patients with diabetic retinopathy and its relationship with disease stages

HU Huan; ZHOU Yuling; ZHANG Yong; GUO Ming

doi:10.7619/jcmp.20211223

Journal of Clinical Medicine in Practice > 2021 > 25(19): 93-97. > DOI: 10.7619/jcmp.20211223

HU Huan, ZHOU Yuling, ZHANG Yong, GUO Ming. Expression of serum factors in patients with diabetic retinopathy and its relationship with disease stages[J]. Journal of Clinical Medicine in Practice, 2021, 25(19): 93-97. DOI: 10.7619/jcmp.20211223

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Expression of serum factors in patients with diabetic retinopathy and its relationship with disease stages

1.
Ophthalmology Department, Xishui Hospital Affiliated to Hubei University of Science and Technology, Huanggang, Hubei, 438200
2.
Department of Ophthalmology, Huangshi Central Hospital of Edong Medical Group, Affiliated Hospital of Hubei Institute of Technology, Huangshi, Hubei, 435000
3.
Jingzhou Central Hospital of Hubei Province, Jingzhou, Hubei, 434000

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Received Date: March 21, 2021
Available Online: October 27, 2021
Published Date: October 14, 2021

Graphical Abstract

Abstract

Abstract

Objective To investigate the expressions of extracellular superoxide dismutase (ecSOD), brain-derived neurotrophic factor(BDNF) and angiopoietin-2(Ang-2) in patients with diabetic retinopathy(DR) and their relationships with the stages of the disease.
Methods A total of 126 diabetic patients were divided into non-diabetic retinopathy group (NDR, 40 cases), background diabetic retinopathy group (BDR, 44 cases), and proliferative diabetic retinopathy group (PDR, 42 cases) according to diabetic retinopathy stages. At the same time, 40 healthy people in the same period were selected as control group. The general data, fasting blood glucose (FBG), glycosylated hemoglobin(HbA1c), serum ecSOD, BDNF and Ang-2 levels were compared among the four groups. The correlations between DR stages and serum ecSOD, BDNF as well as Ang-2 were analyzed. The clinical values of serum ecSOD, BDNF, Ang-2 alone and their combination in the diagnosis of DR were evaluated.
Results The levels of FBG and HbA1c in the NDR group, BDR group and PDR group were significantly higher than those in the control group (P < 0.05), but there were no significant between-group differences in NDR group, BDR group and PDR group (P>0.05). The levels of serum ecSOD, BDNF and Ang-2 in DR patients increased with the increase of pathological grading (P < 0.05). Spearman correlation analysis showed that there was a positive correlation between the stages of DR and the levels of serum ecSOD, BDNF as well as Ang-2 (P < 0.05). The area under the curve (AUC) of ecSOD in diagnosis of DR was 0.836, the cut-off value was 113.43 ng/mL, the sensitivity and specificity were 73.02% and 95.00%, respectively. The AUC of BDNF in the diagnosis of DR was 0.774, the cut-off value was 1.66 ng/mL, the sensitivity and specificity were 71.25% and 94.55%, respectively. The AUC of Ang-2 in the diagnosis of DR was 0.862, the cutoff value was 1.69 μg/L, the sensitivity and specificity were 80.16% and 90.00%, respectively. The AUC of combined detection was 0.904, sensitivity and specificity were 91.27% and 98.03%, respectively.
Conclusion The levels of serum ecSOD, BDNF and Ang-2 in DR patients are significantly increased, and they are closely related to the stages of retinopathy, which are expected to be important indexes for DR diagnosis, treatment and prognosis evaluation.
- diabetic retinopathy,
- extracellular superoxide dismutase,
- brain-derived neurotrophic factor,
- angiopoietin-2,
- pathological stage,
- relationship

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References (19)

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