Value of expression level of lncRNA-p3134 in diagnosing gestational diabetes mellitus

  Objective  To explore the value of peripheral blood lncRNA-p3134 in diagnosing gestational diabetes mellitus (GDM).

  Methods  A total of 82 pregnant women with GDM were selected as GDM group, and 116 non-GDM pregnant women were selected as control group. The expression levels of lncRNA-p3134 in peripheral blood of the two groups were detected; the correlations between the expression of lncRNA-p3134 and insulin resistance index (HOMA-IR), insulin sensitivity index (ISOGTT), islet β cell function index (HOMA-β) and the occurrence of GDM were analyzed. The effect of lncRNA-p3134 expression on the occurrence of GDM and the role of lncRNA-p3134 in the diagnosis of GDM were analyzed.

  Results  The relative expression level of lncRNA-p3134 in the GDM group was significantly higher than that in the control group (P < 0.05). LncRNA-p3134 expression was negatively correlated with ISOGTT and HOMA-β (P < 0.05), and positively correlated with HOMA-IR and GDM (P < 0.05). After adjusting confounding factors, lncRNA-p3134 expression was an independent factor affecting the occurrence of GDM (P < 0.05), and the higher the relative expression level of lncRNA-p3134 was the higher the risk of GDM would be. Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC)of lncRNA-p3134 for GDM diagnosis was 0.853, sensitivity and specificity were 75.0% and 83.0%, respectively.

  Conclusion  The expression level of lncRNA-p3134 in GDM is higher than that of non-GDM, which may lead to the occurrence of GDM by affecting insulin sensitivity and islet β cell function, and it may be used as a candidate marker for the diagnosis of GDM in clinical practice.