Correlations between serum uric acid, high sensitivity C-reactive protein levels and cognitive function after acute cerebral infarction

  Objective   To analyze the correlations between the expressions of serum uric acid (BUA), high sensitivity C-reactive protein (hs-CRP) and mild cognitive dysfunction after acute cerebral infarction (ACI).

  Methods   A total of 150 patients with ACI who were hospitalized were retrospectively included as the research subjects, the cognitive function of all patients was evaluated after their condition was stable, and the patients were divided into cognitive dysfunction group and non-cognitive dysfunction group according to the condition of cognitive dysfunction. The occurrence of cognitive dysfunction in patients was counted and all patients received the detection of serum BUA and hs-CRP levels on admission, the correlations between serum BUA, hs-CRP and mild cognitive dysfunction after ACI were analyzed.

  Results   A total of 66 had mild cognitive dysfunction, accounting for 44.00%. The levels of serum BUA and hs-CRP in the cognitive dysfunction group on admission were higher than those in the non-cognitive dysfunction group (P < 0.05). Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) scores were negatively corrected with serum BUA, hs-CRP levels (rs < 0, P < 0.05).

  Conclusion   Serum BUA and hs-CRP levels are associated with mild cognitive dysfunction after ACI. With the increase of serum BUA and hs-CRP levels, the risk of mild cognitive dysfunction in patients is increased.