Objective To analyze the genetic screening result of drug-induced deafness in 300 pregnant women with normal hearing in Taixing area of Jiangsu Province.
Methods Totally 300 pregnant women were selected as research subjects. The A1555G and C1494T mutation sites of mitochondrial DNA 12S rRNA were screened by fluorescent polymerase chain reaction (PCR), and the same mutation sites were also screened in the offspring of carriers of pregnant women.
Results Among 300 pregnant women, the carrying rate of A1555G mutation was 0.67% (2/300), and the C1494T mutation was not found. The neonates of the two carriers of pregnant women had A1555G mutation, but they all passed the neonatal hearing screening.
Conclusion It is of great significance to carry out mutation screening of drug-induced deafness in pregnant women in Taixing area of Jiangsu Province, which can provide reasonable medication guidance and genetic counseling for mutation carriers and their offspring, and reduce the incidence of drug-induced deafness.
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