LIU Dehui, YAN Yulan. Research progress of circRNAs in diagnosis and prognosis of lung cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 124-128. DOI: 10.7619/jcmp.20211851
Citation: LIU Dehui, YAN Yulan. Research progress of circRNAs in diagnosis and prognosis of lung cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 124-128. DOI: 10.7619/jcmp.20211851

Research progress of circRNAs in diagnosis and prognosis of lung cancer

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  • Received Date: May 04, 2021
  • Available Online: July 07, 2021
  • Published Date: July 14, 2021
  • Lung cancer is one of the most common cancers with the highest incidence and mortality. At present, imaging and pathological biopsy are mainly used for early screening and diagnosis in clinical practice. Circular RNA (circRNA) is stably present in lung cancer tissues and body fluids of patients, and is a promising biomarker for cancer diagnosis and prognosis evaluation. In this paper, the role and value of circRNA in the diagnosisand prognosis evaluation of lung cancer were reviewed from the perspectives of lung cancer tissue and body fluid, and the problems existing in current clinical studies were also discussed.
  • [1]
    FENG R M, ZONG Y N, CAO S M, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics[J]. Cancer Commun, 2019, 39(1): 22. doi: 10.1186/s40880-019-0368-6
    [2]
    BALGKOURANIDOU I, LILOGLOU T, LIANIDOU E S. Lung cancer epigenetics: emerging biomarkers[J]. Biomark Med, 2013, 7(1): 49-58. doi: 10.2217/bmm.12.111
    [3]
    LIU J, YANG X, ZHANG L, et al. Microarray analysis of the expression profile of immune-related gene in rapid recurrence early-stage lung adenocarcinoma[J]. J Cancer Res Clin Oncol, 2020, 146(9): 2299-2310. doi: 10.1007/s00432-020-03287-7
    [4]
    SANGER H L, KLOTZ G, RIESNER D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures[J]. Proc Natl Acad Sci USA, 1976, 73(11): 3852-3856. doi: 10.1073/pnas.73.11.3852
    [5]
    LU W Y. Roles of the circular RNA circ-Foxo3 in breast cancer progression[J]. Cell Cycle, 2017, 16(7): 589-590. doi: 10.1080/15384101.2017.1278935
    [6]
    LIU T M, SONG Z, GAI Y L. Circular RNA circ_0001649 Acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p[J]. Biochem Biophys Res Commun, 2018, 503(3): 1503-1509. doi: 10.1016/j.bbrc.2018.07.070
    [7]
    SALMENA L, POLISENO L, TAY Y, et al. A CeRNA hypothesis: the Rosetta Stone of a hidden RNA language[J]. Cell, 2011, 146(3): 353-358. doi: 10.1016/j.cell.2011.07.014
    [8]
    YANG Y, FAN X J, MAO M W, et al. Extensive translation of circular RNAs driven by N6-methyladenosine[J]. Cell Res, 2017, 27(5): 626-641. doi: 10.1038/cr.2017.31
    [9]
    JECK W R, SHARPLESS N E. Detecting and characterizing circular RNAs[J]. Nat Biotechnol, 2014, 32(5): 453-461. doi: 10.1038/nbt.2890
    [10]
    GUO J U, AGARWAL V, GUO H L, et al. Expanded identification and characterization of mammalian circular RNAs[J]. Genome Biol, 2014, 15(7): 409. doi: 10.1186/s13059-014-0409-z
    [11]
    YAN Y L, ZHANG R T, ZHANG X F, et al. RNA-Seq profiling of circular RNAs and potential function of hsa_circ_0002360 in human lung adenocarcinom[J]. Am J Transl Res, 2019, 11(1): 160-175.
    [12]
    张垚, 张日婷, 陈正威, 等. Hsa_circ_0002360在肺腺癌中的表达及临床意义[J]. 医学研究生学报, 2019, 32(11): 1179-1183. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYB201911013.htm
    [13]
    NAN A, CHEN L J, ZHANG N, et al. Circular RNA circNOL10 inhibits lung cancer development by promoting SCLM1-mediated transcriptional regulation of the humanin polypeptide family[J]. Adv Sci (Weinh), 2019, 6(2): 1800654. doi: 10.1002/advs.201800654
    [14]
    LI Z, RUAN Y, ZHANG H Y, et al. Tumor-suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets[J]. Cancer Sci, 2019, 110(12): 3630-3638. doi: 10.1111/cas.14211
    [15]
    CHEN D S, MA W, KE Z Y, et al. CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression[J]. Cell Cycle, 2018, 17(16): 2080-2090. doi: 10.1080/15384101.2018.1515553
    [16]
    LI J P, WANG J H, CHEN Z, et al. Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer[J]. Gene, 2018, 665: 1-5. doi: 10.1016/j.gene.2018.04.059
    [17]
    ZONG L, SUN Q C, ZHANG H P, et al. Increased expression of circRNA_102231 in lung cancer and its clinical significance[J]. Biomedecine Pharmacother, 2018, 102: 639-644. doi: 10.1016/j.biopha.2018.03.084
    [18]
    ZHANG S Y, ZENG X L, DING T, et al. Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer[J]. Sci Rep, 2018, 8(1): 2878. doi: 10.1038/s41598-018-21300-5
    [19]
    ZHANG Y N, ZHAO H, ZHANG L C. Identification of the tumor suppressive function of circular RNA FOXO3 in non small cell lung cancer through sponging miR? 155[J]. Mol Med Rep, 2018, 17(6): 7692-7700.
    [20]
    YAO J T, ZHAO S H, LIU Q P, et al. Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value[J]. Pathol Res Pract, 2017, 213(5): 453-456. doi: 10.1016/j.prp.2017.02.011
    [21]
    WANG C D, TAN S Y, LIU W R, et al. RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma[J]. Mol Cancer, 2019, 18(1): 134. doi: 10.1186/s12943-019-1061-8
    [22]
    ZOU Q G, WANG T J, LI B, et al. Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer[J]. Oncol Lett, 2018, 16(5): 5551-5556.
    [23]
    ZHU X, HAN J, LAN H Y, et al. A novel circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulates cisplatin-resistance in non-small cell lung cancer (NSCLC)[J]. BMC Cancer, 2020, 20(1): 1190. doi: 10.1186/s12885-020-07680-w
    [24]
    LIU W, MA W M, YUAN Y, et al. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302[J]. Biochem Biophys Res Commun, 2018, 500(4): 846-851. doi: 10.1016/j.bbrc.2018.04.172
    [25]
    GONG P, XU R, ZHUANG Q, et al. A novel circular RNA (hsa_circRNA_102336), a plausible biomarker, promotes the tumorigenesis by sponging miR-515-5p in human bladder cancer[J]. Biomedicine & Pharmacotherapy, 2020, 126: 110059.
    [26]
    LI X P, YANG B, REN H X, et al. Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p[J]. Cell Death Dis, 2019, 10(12): 953. doi: 10.1038/s41419-019-2180-2
    [27]
    SU M, XIAO Y H, MA J L, et al. Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers[J]. Mol Cancer, 2019, 18(1): 90. doi: 10.1186/s12943-019-1002-6
    [28]
    TAN S Y, GOU Q H, PU W C, et al. Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer[J]. Cell Res, 2018, 28(6): 693-695. doi: 10.1038/s41422-018-0033-7
    [29]
    LU G J, CUI J, QIAN Q, et al. Overexpression of hsa_circ_0001715 is a potential diagnostic and prognostic biomarker in lung adenocarcinoma[J]. Onco Targets Ther, 2020, 13: 10775-10783. doi: 10.2147/OTT.S274932
    [30]
    LI X Y, ZHANG Z L, JIANG H, et al. Circular RNA circPVT1 promotes proliferation and invasion through sponging miR-125b and activating E2F2 signaling in non-small cell lung cancer[J]. Cell Physiol Biochem, 2018, 51(5): 2324-2340. doi: 10.1159/000495876
    [31]
    LUO Y H, YANG Y P, CHIEN C S, et al. Plasma level of circular RNA hsa_circ_0000190 correlates with tumor progression and poor treatment response in advanced lung cancers[J]. Cancers (Basel), 2020, 12(7): E1740. doi: 10.3390/cancers12071740
    [32]
    LIU X X, YANG Y E, LIU X, et al. A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma[J]. J Transl Med, 2019, 17(1): 50. doi: 10.1186/s12967-019-1800-z
    [33]
    ZHANG L, YU D H. Exosomes in cancer development, metastasis, and immunity[J]. Biochim Biophys Acta Rev Cancer, 2019, 1871(2): 455-468. doi: 10.1016/j.bbcan.2019.04.004
    [34]
    LI Y, ZHENG Q P, BAO C Y, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis[J]. Cell Res, 2015, 25(8): 981-984. doi: 10.1038/cr.2015.82
    [35]
    XIAN J F, SU W P, LIU L, et al. Identification of three circular RNA cargoes in serum exosomes as diagnostic biomarkers of non-small-cell lung cancer in the Chinese population[J]. J Mol Diagn, 2020, 22(8): 1096-1108. doi: 10.1016/j.jmoldx.2020.05.011
    [36]
    HE F, ZHONG X J, LIN Z, et al. Plasma exo-hsa_circRNA_0056616: a potential biomarker for lymph node metastasis in lung adenocarcinoma[J]. J Cancer, 2020, 11(14): 4037-4046.
    [37]
    LI L Y, LI W, CHEN N F, et al. FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer[J]. Clin Cancer Res, 2019, 25(4): 1302-1317. http://www.ncbi.nlm.nih.gov/pubmed/30429198
    [38]
    WANG J, ZHAO X, WANG Y, et al. circRNA-002178 act as a CeRNA to promote PDL1/PD1 expression in lung adenocarcinoma[J]. Cell Death Dis, 2020, 11(1): 32.
    [39]
    MA J, QI G B, LI L. A novel serum exosomes-based biomarker hsa_circ_0002130 facilitates osimertinib-resistance in non-small cell lung cancer by sponging miR-498[J]. Onco Targets Ther, 2020, 13: 5293-5307. http://www.researchgate.net/publication/342019711_A_Novel_Serum_Exosomes-Based_Biomarker_hsa_circ_0002130_Facilitates_Osimertinib-Resistance_in_Non-Small_Cell_Lung_Cancer_by_Sponging_miR-498
    [40]
    杨桄权, 张千仕, 范习刚, 等. 非小细胞肺癌患者癌组织及血清中circRNA的表达水平及临床意义[J]. 分子诊断与治疗杂志, 2020, 12(8): 1014-1017. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYQ202008008.htm
    [41]
    ZHOU X, LIU H Y, WANG W Y, et al. Hsa_circ_0102533 serves as a blood-based biomarker for non-small-cell lung cancer diagnosis and regulates apoptosis in vitro[J]. Int J Clin Exp Pathol, 2018, 11(9): 4395-4404.
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