Objective To observe the expressions of circulating tumor cells (CTCs), microribonucleic acid 1246 (MiR-1246), carbohydrate antigen 153 (CA153) levels in breast cancer patients, and to explore their relationships with different clinicopathological features and prognosis.
Methods A total of 108 patients with breast cancer were enrolled as breast cancer group, and another 100 patients with benign breast tumor were enrolled as benign tumor group. During the same period, 100 healthy subjects with physical examinations were collected as control group. The expression differences of CTCs, miR-1246 and CA153 among the three groups were compared, their diagnostic values and their relationships with the clinicopathological characteristics and prognosis of breast cancer patients were analyzed.
Results The levels of CTCs, miR-1246 and CA153 in the breast cancer group were significantly higher than those in the benign tumor group, and the above indicators in the benign tumor group were significantly higher than those in the control group (P < 0.05). The diagnostic efficiency of the combined detection was significantly higher than the detection alone, and the sensitivity and specificity reached 90.1% and 84.8%. The levels of CTCs, miR-1246 and CA153 were closely correlated with age, pathological type, TNM stage, histological grade and lymph node metastasis of breast cancer patients (P < 0.05). TNM stage, histological grade, lymph node metastasis, CTCs, miR-1246, and CA153 expressions were independent risk factors for prognosis of breast cancer patients.
Conclusion CTCs, miR-1246 and CA153 expressions are significantly increased in breast cancer patients, and are closely related to different clinicopathological characteristics and prognosis of breast cancer patients. Combined detection can be used as effective indicators for early diagnosis for breast cancer and judgment of prognosis.
DownLoad: