Advance Search
LIU Mingtao, PANG Yanrong, ZHAO Liang, WEN Zhongzheng, HOU Guoqing. Expression and clinical significance of microRNA-210 and lipoprotein-associated phospholipase A2 in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 39-42. DOI: 10.7619/jcmp.20212085
Citation: LIU Mingtao, PANG Yanrong, ZHAO Liang, WEN Zhongzheng, HOU Guoqing. Expression and clinical significance of microRNA-210 and lipoprotein-associated phospholipase A2 in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 39-42. DOI: 10.7619/jcmp.20212085
shu

Expression and clinical significance of microRNA-210 and lipoprotein-associated phospholipase A2 in patients with coronary heart disease

  • Department of Cardiology, Wenjiang Hospital of Sichuan Provincial People's Hospital, Chengdu, Sichuan, 611130

More Information
  • Received Date: May 18, 2021
  • Available Online: December 02, 2021
  • Published Date: November 14, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the expression and clinical significance of microRNA-210(miR-210) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in peripheral blood of patients with coronary heart disease.
      Methods  A total of 113 patients with coronary heart disease were selected as research objects, and were positive coronary angiography at admission(stenosis of vessel diameter of 50% and above). According to the classification of coronary heart disease, the patients were divided into acute myocardial infarction (AMI) group (42 cases), stable angina pectoris (SAP) group (37 cases) and unstable angina pectoris (UAP) group (34 cases). Another 106 patients with suspected coronary heart disease with negative coronary angiography (vessel diameter stenosis < 50%) during the same period were included in control group. Quantitative Real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) were used to detect the levels of miR-210, Lp-PLA2 and related indicators of cardiac function[Stroke output (SV), cardiac index (CI) and left ventricular ejection fraction (LVEF), degree of coronary artery disease (Gensini score)] in peripheral blood within 24 h after admission without drug treatment, and were conducted Pearson correlation analysis. Multivariate Logistic regression analysis was used to explore the main risk factors of coronary heart disease.
      Results  The relative expressions of miR-210 and Lp-PLA2 in peripheral blood of the AMI group, SAP group and UAP group were significantly higher than those of the control group, while the cardiac function indexes were significantly lower than those of the control group(P < 0.05). The results of Pearson correlation analysis showed that miR-210 in peripheral blood of patients with coronary heart disease was positively correlated with Lp-PLA2 (P < 0.05), and both of them were negatively correlated with SV, CI and LVEF, and positively correlated with Gensini score of coronary artery disease degree (P < 0.05). Multivariate stepwise Logistic regression analysis showed that miR-210 and Lp-PLA2 were independent risk factors for patients with coronary heart disease.
      Conclusion  MiR-210 and Lp-PLA2 in peripheral blood are closely related to the occurrence and development of coronary heart disease. They can predict the potential risk of coronary heart disease, and have positive significance for the early diagnosis, treatment and prognosis evaluation of coronary heart disease.
    • FullText(HTML)
    • References (12)
  • [1]
    KARAKAS M, SCHULTE C, APPELBAUM S, et al. Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study[J]. Eur Heart J, 2017, 38(7): 516-523. http://www.onacademic.com/detail/journal_1000039191722410_5bab.html
    [2]
    YANG L, WANG H, ZHANG Y, et al. The prognostic value of lipoprotein-associated phospholipase A2 in the long-term care of patients with acute coronary syndrome undergoing percutaneous coronary intervention[J]. Clin Appl Thromb Hemost, 2018, 24(5): 822-827. doi: 10.1177/1076029617737837
    [3]
    YANG L, LIU Y, WANG S, et al. Association between Lp-PLA2 and coronary heart disease in Chinese patients[J]. J Int Med Res, 2017, 45(1): 159-169. doi: 10.1177/0300060516678145
    [4]
    DE MAURI A, VIDALI M, CHIARINOTTI D, et al. Lipoprotein-associated phospholipase A2 predicts cardiovascular events in dialyzed patients[J]. J Nephrol, 2019, 32(2): 283-288. doi: 10.1007/s40620-018-0521-3
    [5]
    ZHANG H, HAO J, SUN X, et al. Circulating pro-angiogenic micro-ribonucleic acid in patients with coronary heart disease[J]. Interact Cardiovasc Thorac Surg, 2018, 27(3): 336-342. http://www.onacademic.com/detail/journal_1000040263291210_a8df.html
    [6]
    李馨航, 李沅洋, 孙旭森, 等. R2CHA2DS2-VASc评分对急性心肌梗死后发生急性心力衰竭风险的预测价值[J]. 天津医药, 2021, 49(3): 281-284. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ202103013.htm
    [7]
    HU Y, LI T T, ZHOU W, et al. Lipoprotein-associated phospholipase A2 is a risk factor for diabetic kidney disease[J]. Diabetes Res Clin Pract, 2019, 150: 194-201. doi: 10.1016/j.diabres.2019.03.026
    [8]
    YOUNUS A, HUMAYUN C, AHMAD R, et al. Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: a systematic review[J]. J Clin Lipidol, 2017, 11(2): 328-337. doi: 10.1016/j.jacl.2017.02.005
    [9]
    李道麟, 董平栓, 赵江峰, 等. 冠心病患者血清Lp-PLA2、sdLDL-C水平变化及临床意义[J]. 中国循证心血管医学杂志, 2019, 11(3): 316-319. doi: 10.3969/j.issn.1674-4055.2019.03.12
    [10]
    ZHENG D, CAI A, XU R, et al. Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia[J]. Arch Med Sci, 2018, 14(3): 629-634. doi: 10.5114/aoms.2017.69494
    [11]
    TORIBIO M, FITCH K V, STONE L, et al. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial[J]. EBioMedicine, 2018, 35: 58-66. doi: 10.1016/j.ebiom.2018.08.039
    [12]
    ZHANG M M, ZHANG C G, YANG C J, et al. The association between the D166E polymorphism of the lipoprotein associated phospholipase A2 and risk of myocardial infarction[J]. Eur Rev Med Pharmacol Sci, 2019, 23(9): 3960-3966. http://www.ncbi.nlm.nih.gov/pubmed/31115024
    • Related Articles

  • Related Articles

    [1]JI Hongjuan, QIAO Dawei, TAO Yuhua. Influencing factors of anxiety and depression in lung cancer patients and analysis in Chinese traditional medicine syndromes[J]. Journal of Clinical Medicine in Practice, 2022, 26(14): 60-63, 69. DOI: 10.7619/jcmp.20220656
    [2]XU Ke, AN Xiaolei, LI Xiaobin, GUO Jing, LI Chuanling. Related factors of vascular cognitive impairment in patients with acute cerebral infarction and establishment of prediction model[J]. Journal of Clinical Medicine in Practice, 2022, 26(6): 1-5. DOI: 10.7619/jcmp.20214684
    [3]CHEN Ying, XU Fengqin, XU Qin, WANG Dongyan. Occurrence of perioperative depression in elderly patients with osteoporotic fractures and its influencing factors[J]. Journal of Clinical Medicine in Practice, 2021, 25(20): 97-101. DOI: 10.7619/jcmp.20211545
    [4]ZHOU Jinjing, CHU Aijiong, BU Yinhua. Influence of cognitive behavior intervention on self acceptance function of patients with depression[J]. Journal of Clinical Medicine in Practice, 2017, (18): 11-12,19. DOI: 10.7619/jcmp.201718004
    [5]ZENG Dehua. Analysis in the risk factors of early vascular cognitive impairment after ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2017, (15): 14-17. DOI: 10.7619/jcmp.201715004
    [6]TAN Zhihui, TANG Qiqun, CHENG Jie. The status and influencing factors of work values of ICU nurses[J]. Journal of Clinical Medicine in Practice, 2017, (10): 130-133. DOI: 10.7619/jcmp.201710039
    [7]XIONG Dongmei, TIAN Jing, HUANG Xiaodan. Analysis of self nursing ability and influencing factors in tumor patients with PICC[J]. Journal of Clinical Medicine in Practice, 2016, (16): 78-81. DOI: 10.7619/jcmp.201616024
    [8]JIA Jing, QIANG Xiaoling. Influence of comprehensive nursing interventions on depressive emotion and QOL in patients with depression[J]. Journal of Clinical Medicine in Practice, 2015, (16): 14-16. DOI: 10.7619/jcmp.201516005
    [9]REN Xiuqiong. Perinatal mental state of primiparas and its influencing factors[J]. Journal of Clinical Medicine in Practice, 2014, (10): 122-123,126. DOI: 10.7619/jcmp.201410045
    [10]WU Jingwen. Research of influential factors on anxiety and depression emotions in voluntary blood donors[J]. Journal of Clinical Medicine in Practice, 2013, (10): 45-48. DOI: 10.7619/jcmp.201310018

  • Cited by

    Periodical cited type(14)

    1. 潘新萍，乔惠霞. 预见性思维对内分泌科护理管理质量影响的探究. 卫生职业教育. 2023(02): 143-145 .
    2. 王璐，程荣花，孙文馨. 预见性护理在妇科恶性肿瘤单孔腹腔镜治疗中的应用效果. 黑龙江中医药. 2022(01): 300-302 .
    3. 王佑招. 预见性护理联合空气波压力循环治疗仪对子宫肌瘤切除术后下肢深静脉血栓形成的预防效果. 医疗装备. 2021(09): 180-182 .
    4. 刘文娟，吴雪华，郑红霞. 思维导图护理对宫颈癌根治术后患者康复期心理状况及预后的影响. 中国医药导报. 2021(17): 193-196 .
    5. 刘霞，凌钰. 护理安全管理中对低年资护士预见性思维能力培养的效果分析. 实用临床护理学电子杂志. 2020(06): 168+170 .
    6. 张勃，毛亚平，袁鹤平. 循证护理在纵隔镜手术患者中的应用. 齐鲁护理杂志. 2020(06): 52-54 .
    7. 陈薇. 25例经脐单孔腹腔镜妇科手术配合及护理要点. 中国城乡企业卫生. 2020(05): 119-121 .
    8. 陈丽娟. 感染疾病科陪护中应用预见性护理管理的可行性分析. 中西医结合心血管病电子杂志. 2020(19): 150+154 .
    9. 秦惠军. 腹腔镜下良性卵巢肿瘤剔除术的手术护理配合. 中国医药指南. 2020(23): 219-220 .
    10. 马韶红，余春玲，韩美荣. 预见性护理在急性心肌梗死院前急救中的应用效果分析. 智慧健康. 2020(22): 158-159 .
    11. 毛希虹，金丽娟，施春香，沈瑜. 优质护理对恶性肿瘤化疗患者生活质量的影响研究. 中国肿瘤临床与康复. 2020(10): 1203-1206 .
    12. 单锦霞，郑艳莉，吴小丽. 预见性护理在预防妇科恶性肿瘤紫杉醇化疗患者不良反应中的应用效果. 实用医院临床杂志. 2020(06): 126-128 .
    13. 张娟，刘羽，郑丽芳，梁金玉，杨琼，李珍. 预见性护理干预降低3D腹腔镜宫颈癌根治术并发症的研究. 中国当代医药. 2020(30): 210-212 .
    14. 周华. 手术室预见性护理干预对妇科腹腔镜手术患者麻醉苏醒期躁动的影响. 系统医学. 2019(19): 162-164 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views PDF downloads Cited by(14)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return