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GAO Juan, WANG Xia, XIA Yafang, HUA Caifeng. Effect of photodynamic therapy in treatment of low-grade cervical intraepithelial neoplasia[J]. Journal of Clinical Medicine in Practice, 2021, 25(23): 106-109. DOI: 10.7619/jcmp.20212281
Citation: GAO Juan, WANG Xia, XIA Yafang, HUA Caifeng. Effect of photodynamic therapy in treatment of low-grade cervical intraepithelial neoplasia[J]. Journal of Clinical Medicine in Practice, 2021, 25(23): 106-109. DOI: 10.7619/jcmp.20212281
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Effect of photodynamic therapy in treatment of low-grade cervical intraepithelial neoplasia

  • Department of Obstetrics and Gynecology,Jiangyin Hospital of Traditional Chinese Medicine,Jiangyin,Jiangsu,214400

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  • Received Date: June 01, 2021
  • Available Online: December 05, 2021
  • Published Date: December 14, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To observe effect of photodynamic therapy (PDT) in treatment of low-grade cervical squamous intraepithelial lesion (LSIL) and its influences on expressions of serum low-density lipoprotein receptor associated protein-6 (LRP-6) and hyaluronic acid (HA).
      Methods  A total of 90 patients with LSIL were prospectively included,and were divided into two groups according to random number table method,with 45 cases in each group.The control group was treated with CO2laser,and the observation group was treated with PDT,the patients were treated once a month and observed for 6 months after 3 times of treatment.The treatment effect,levels of serum LRP-6 and HA,adverse reactions and recurrence of the two groups were compared.
      Results  The overall treatment effect of the observation group at 3 months of treatment was better than that of the control group,and the total effective rate was higher than that of the control group (P < 0.05); at the end of treatment,the levels of serum LRP-6 and HA in both groups were decreased than those before treatment,and were lower in the observation group than those in the control group (P < 0.05).There was no significant difference in the incidence of adverse reactions between two groups during treatment (P>0.05).The recurrence rate of the observation group after 6 months of follow-up was lower than that of the control group(P>0.05).
      Conclusion  PDT has good clinical effect in the treatment of patients with LSIL,can regulate the levels of serum LRP and HA.
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    • References (16)
  • [1]
    GUAN X H,XU T H,CHEN X,et al.Fractionated carbon dioxide (CO2) laser treatment contributes to trans-nail penetration of rhodamine B and changes of cytokine microenvironment[J].Lasers Med Sci,2021,36(8): 1619-1623. doi: 10.1007/s10103-020-03232-7
    [2]
    李瑞,葛静,秦琳,等.光动力疗法对阴道上皮内瘤变1~2级患者预后的影响[J].实用临床医药杂志,2019,23(12): 26-28.
    [3]
    卢笛,雷志英,黄金台,等.Wnt信号通路蛋白在宫颈上皮内瘤变及宫颈鳞癌中的表达及其与高危型HPV感染的相关性[J].武汉大学学报: 医学版,2016,37(6): 880-883.
    [4]
    YE H,CHE J,HUANG R,et al.Zwitterionic peptide enhances protein-resistant performance of hyaluronic acid-modified surfaces[J].Langmuir,2020,36(8): 1923-1929. doi: 10.1021/acs.langmuir.9b03856
    [5]
    ATHANASIOU A,VERONIKI A A,EFTHIMIOU O,et al.Comparative efficacy and complication rates after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE Group[J].BMJ Open,2019,9(8): e028008. doi: 10.1136/bmjopen-2018-028008
    [6]
    谢幸,孔北华,段涛.妇产科学[M].9版.北京: 人民卫生出版社,2018: 296-297.
    [7]
    吕佩瑾,鲁永鲜.妇科疾病诊断与疗效标准[M].上海: 上海中医药大学出版社,2006: 25-25.
    [8]
    RAJBANSHI B,SHEN L,JIANG M,et al.Comparative study of traditional ablative CO2 laser-assisted topical antifungal with only topical antifungal for treating onychomycosis: a multicenter study[J].Clin Drug Investig,2020,40(6): 575-582. doi: 10.1007/s40261-020-00914-6
    [9]
    LI RUI,LIU LI'NA,CHEN LIDA.氨乙酰丙酸介导的光动力疗法对宫颈人乳头瘤病毒感染合并宫颈上皮内瘤变的疗效影响[J].实用临床医药杂志,2019,23(11): 63-65,69.
    [10]
    AITKEN C A,SIEBERS A G,MATTHIJSSE S M,et al.Management and treatment of cervical intraepithelial neoplasia in the Netherlands after referral for colposcopy[J].Acta Obstet Gynecol Scand,2019,98(6): 737-746. doi: 10.1111/aogs.13547
    [11]
    翟瑞芳,贺红霞,张三元.艾拉光动力治疗宫颈高危型人乳头瘤病毒持续感染的临床疗效及安全性研究[J].中国药物与临床,2019,19(16): 2785-2787.
    [12]
    李苑瑛.清热利湿益肾解毒汤治疗子宫颈上皮内瘤变疗效及对GDF-15、Wnt-11、LRP-6水平影响的机制研究[J].中华中医药学刊,2020,38(1): 184-186.
    [13]
    丁莉,俞碧霞,顾海燕,等.宫颈上皮内瘤变及宫颈癌患者血清透明质酸与CD44的变化及意义[J].中国卫生检验杂志,2019,29(10): 1186-1188,1193.
    [14]
    程梦星.光动力治疗在宫颈疾病中的应用[J].现代妇产科进展,2020,29(5): 397-399.
    [15]
    李瑞,葛静,周迪兰,等.5-氨基酮戊酸光动力治疗高危型人乳头状瘤病毒宫颈持续感染疗效观察[J].陕西医学杂志,2019,48(7): 930-932,957. doi: 10.3969/j.issn.1000-7377.2019.07.033
    [16]
    孟祖东,杜天平,王玉,等.光动力疗法治疗恶性皮肤肿瘤及癌前期皮肤病临床疗效及不良反应分析[J].中国中西医结合皮肤性病学杂志,2019,18(4): 348-350. doi: 10.3969/j.issn.1672-0709.2019.04.019
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