Objective To explore the effect of ozonated autohemotransfusion on myocardial injury of patients with coronary artery abnormality after non-cardiac surgery.
Methods Totally 90 patients with selective radical resections of gastric, intestinal and esophageal cancers were randomly divided into ozonated autohemotransfusion group (n=45) and control group (n=45). The ozonated autohemotransfusion group was treated with ozonated autohemotransfusion therapy at the time points of the day of operation and the first day and second days after operation, while the control group was only treated with autohemotransfusion. Venous blood was collected for detection of cardiac troponin I (cTnI) and cardiac troponin T (cTnT) in plasma at the time points of before anesthesia (T0) and 6, 12, 24 and 48 hours after surgery (T1, T2, T3, T4). Tricuspid annular plane systolic excursion (TAPSE) and left ventricular ejection fraction (LVEF) were measured by transthoracic ultrasound. Vasoactive inotrope score (VIS), C reactive protein (CRP), interleukin-6 (IL-6) and intraoperative time-weighted average mean arterial pressure (TWA-MAP) were recorded at 24 hours after operation.
Results The levels of cTnI and cTnT in both groups raised in varying degrees after surgery, and the cTnI and cTnT levels at T2, T3 and T4 in the ozonated autohemotransfusion group were significantly lower than those in the control group (P < 0.05). Compared with the control group, the LVEF and TAPSE at T1, T2 and T3 increased significantly in the ozonated autohemotransfusion group, while the VIS decreased significantly at 24 hours after operation (P < 0.05). Compared with the control group, the CRP and IL-6 significantly decreased at 24 hours after operation in the ozonated autohemotransfusion group (P < 0.05).
Conclusion Ozonated autohemotransfusion can improve the myocardial injury of patients with coronary artery abnormality after non-cardiac surgery.
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