Influence of high-density lipoprotein on immune cells distribution in peripheral blood of patients with ischemic stroke at acute stage

  Objective  To analyze the influence of high-density lipoprotein (HDL) on immune cells distribution in peripheral blood of patients with ischemic stroke at acute stage.

  Methods  Totally 42 patients with acute ischemic stroke in Xuanwu Hospital of Capital Medical University were selected as research objects, and the duration from onset to treatment was 7 days and below in all the patients. Blood samples were collected before treatment after admission, the expression level of HDL in peripheral blood was detected, and the percentage of immune cells in peripheral blood was detected by flow cytometer. The patients were divided into HDL < 1.0 mmol/L group (n=22) and HDL≥1.0 mmol/L group (n=20).

  Results  The percentages of CD3⁺ T lymphocytes and CD3⁺CD4⁺ T lymphocytes in peripheral blood in the HDL < 1.0 mmol/L group were significantly higher than those in the HDL≥1.0 mmol/L group, but the percentage of CD3⁺CD8⁺ T lymphocytes was significantly lower than that in the HDL≥1.0 mmol/L group (P < 0.05). There was no significant difference in the percentage of monocytes in peripheral blood between the two groups (P > 0.05).

  Conclusion  In patients with ischemic stroke at acute stage, the patients with higher level of HDL are often accompanied by the recruitment of low levels of CD3⁺ and CD3⁺CD4⁺ T lymphocytes, which may help to reduce brain tissue damage after ischemic stroke.