Effects of Zhima Xiaotan Huoxue Recipe on no-reflow and prognosis after percutaneous coronary intervention in low-risk non-ST-elevation acute coronary syndrome patients

LIU Qi; JIA Yunshi; SONG Wenting; LI Wuwei

doi:10.7619/jcmp.20212580

Journal of Clinical Medicine in Practice > 2021 > 25(24): 69-73. > DOI: 10.7619/jcmp.20212580

LIU Qi, JIA Yunshi, SONG Wenting, LI Wuwei. Effects of Zhima Xiaotan Huoxue Recipe on no-reflow and prognosis after percutaneous coronary intervention in low-risk non-ST-elevation acute coronary syndrome patients[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 69-73. DOI: 10.7619/jcmp.20212580

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Effects of Zhima Xiaotan Huoxue Recipe on no-reflow and prognosis after percutaneous coronary intervention in low-risk non-ST-elevation acute coronary syndrome patients

Department of Cardiology, Shijiazhuang Hospital of Traditional Chinese Medicine of Hebei Province, Shijiazhuang, Hebei, 050000

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Received Date: June 21, 2021
Available Online: December 15, 2021
Published Date: December 27, 2021

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Abstract

Abstract

Objective To explore effects of Zhima Xiaotan Huoxue Recipe on no-reflow and prognosis after percutaneous coronary intervention(PCI) in low-risk non-ST-elevation acute coronary syndrome(NSTE-ACS) patients and its possible action mechanism.
Methods A total of 72 low-risk NSTE-ACS patients who underwent elective PCI were selected as objects and randomly divided into control group and experimental group. A total of 36 patients in the control group were given conventional treatment and nursing by western medicine, and the experimental group orally administrated Zhima Xiaotan Huoxue Decoction 7 days before the operation based on the control group. The blood flow grading (TIMI) after operation, the incidence of no-reflow phenomenon, blood flow grading of TIMI myocardial perfusion grade (TMPG), and incidence of major adverse cardiac events (MACE), left ventricular ejection fraction (LVEF) and N-terminal precursor B type natriuretic peptide (NT-proBNP) 7 days and 30 days after surgery, interleukin (IL)-2, IL-6, hypersensitive C-reactive protein (hs-CRP) and endothelial glycocalyx degradation products heparan, Syndecan-1, hyaluronic acid levels were compared.
Results After the intervention, the proportions of patients with TIMI 3 and TMPG 3 and postoperative LVEF levels in the experimental group were higher than those in the control group (P < 0.05); after intervention, the incidence of no-reflow, postoperative NT-proBNP, IL-2, IL-6, hs-CRP, serum heparan sulfate, Syndecan-1, and hyaluronic acid levels in the experimental group were lower than those of the control group (P < 0.01).
Conclusion Zhima Xiaotan Huoxue Decoction can effectively prevent the occurrence of no-reflow after the low-risk NSTE-ACS after PCI, increase myocardial blood perfusion, reduce the total incidence of MACE, inhibit inflammation, relieve vascular endothelial damage, and improve cardiac function and prognosis.

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