Correlations of serum 25-hydroxyvitamin D<sub>3</sub> with glucose metabolism, liver function and disease progression of patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease

SUN Na; HE Minghai; YANG Wenxiang; LI Xuelu

doi:10.7619/jcmp.20212823

Journal of Clinical Medicine in Practice > 2022 > 26(1): 89-94. > DOI: 10.7619/jcmp.20212823

SUN Na, HE Minghai, YANG Wenxiang, LI Xuelu. Correlations of serum 25-hydroxyvitamin D₃ with glucose metabolism, liver function and disease progression of patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 89-94. DOI: 10.7619/jcmp.20212823

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Correlations of serum 25-hydroxyvitamin D₃ with glucose metabolism, liver function and disease progression of patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease

1.
Department of Endocrinology, Nanchong Central Hospital in Sichuan Province, Nanchong, Sichuan, 637000
2.
Teaching and Research Section of Microbiology and Immunology, North Sichuan Medical College, Nanchong, Sichuan, 637000

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Received Date: July 12, 2021
Available Online: January 19, 2022
Published Date: January 14, 2022

Graphical Abstract

Abstract

Abstract

Objective To investigate the correlations of serum 25-hydroxyvitamin D₃ [25-(OH)-D₃] with glucose metabolism, liver function and disease progression in patients with type 2 diabetes mellitus (T2DM) complicated with nonalcoholic fatty liver disease (NAFLD).
Methods A total of 128 T2DM patients were enrolled as subjects and divided into T2DM group (n=41) and NAFLD group (n=87) according to whether they had NAFLD or not, and 50 healthy subjects were enrolled as control group. NAFLD group was divided into group A (good blood glucose control), group B (general blood glucose control) and group C (poor blood glucose control) according to the blood glucose control status. According to the NALFD Fibrosis Score (NFS), patients were divided into NFS>0.676 group, NFS -1.455 to 0.676 group and NFS < -1.455 group. The correlation between serum 25-(OH)-D₃ level and glucose metabolism as well as liver function in NAFLD patients were analyzed.
Results The levels of triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and serum 25-(OH)-D₃ in the control group, the T2DM group and the NAFLD group showed significant differences (P < 0.05). Hemoglobin A1c (HbA1c), fasting plasma glucose(FPG), 2-hour plasma glucose (2 hPG), homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of-β cell function (HOMA-β) of NAFLD patients with different blood glucose control levels had statistical differences (P < 0.05). Correlation analysis showed that serum 25-(OH)-D₃ level was positively correlated with HOMA-β in NAFLD patients (P < 0.05); there were significant differences in alanine aminotransferase (ALT) and serum 25-(OH)-D₃ levels among patients with different NFS scores (P < 0.05). Correlation analysis showed that ALT level was positively correlated with serum 25-(OH)-D₃ level in NAFLD patients (P < 0.05).
Conclusion The serum levels of 25-(OH)-D₃ in patients with T2DM and NAFLD are positively correlated with the levels of HOMA-β and ALT, suggesting that vitamin D deficiency may cause poor blood glucose control and promote the progression of liver fibrosis. In addition, detection of serum 25-(OH)-D₃ level also provides a reliable channel for monitoring liver function and fibrosis in NAFLD patients.
- 25-hydroxyvitamin D₃,
- type 2 diabetes mellitus,
- nonalcoholic fatty liver disease,
- glucose metabolism,
- liver function,
- disease progress,
- correlation analysis

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References (15)

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