Correlations between area under curve of time-glucose curve of oral glucose tolerance test and perinatal outcomes in multiparas with gestational diabetes mellitus

  Objective  To explore the correlations between the area under curve (AUC) of time-glucose curve of oral glucose tolerance test (OGTT) and perinatal outcomes in multiparas with gestational diabetes mellitus (GDM).

  Methods  Totally 551 GDM multiparas with single fetus were selected, and they were divided into AUC ≤ 15.59 mmol/(L·h) group, AUC>15.60 to 16.79 mmol/(L·h) group, AUC>16.79 to 17.67 mmol/(L·h) group and AUC>17.67 mmol/(L·h) group. Correlations between AUC and adverse perinatal outcomes were analyzed in GDM multiparas.

  Results  There were significant differences in age and gestational weeks of delivery among the four groups (P < 0.05). There were no significant differences in the incidence rates of preterm delivery, premature rupture of membranes, abnormal amniotic fluid, cesarean section and postpartum hemorrhage among the four groups (P>0.05). The average birth weight of newborns in the AUC ≤ 15.59 mmol/(L·h) group was significantly higher than that in the AUC>15.59 to 16.79 mmol/(L·h) group (P < 0.05). There was significant difference in the incidence of neonates transferring to department of pediatrics among the AUC ≤ 15.59 mmol/(L·h) group, AUC>16.79 to 17.67 mmol/(L·h) group and AUC>17.67 mmol/(L·h) group (P < 0.05). Logistic binary regression analysis showed that AUC was significantly correlated with the incidence of neonates transferring to department of pediatrics in GDM pregnant women (P < 0.05).

  Conclusion  AUC of OGTT time-glucose curve in GDM multiparas can be used as an index for evaluation of blood glucose level, and it has a certain value in predicting the incidence of neonates transferring to department of pediatrics.