Correlations between area under curve of time-glucose curve of oral glucose tolerance test and perinatal outcomes in multiparas with gestational diabetes mellitus

CHEN Ling; CHEN Wenwei; CHEN Li; ZHANG Guoying

doi:10.7619/jcmp.20212937

Journal of Clinical Medicine in Practice > 2021 > 25(19): 98-100, 106. > DOI: 10.7619/jcmp.20212937

CHEN Ling, CHEN Wenwei, CHEN Li, ZHANG Guoying. Correlations between area under curve of time-glucose curve of oral glucose tolerance test and perinatal outcomes in multiparas with gestational diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2021, 25(19): 98-100, 106. DOI: 10.7619/jcmp.20212937

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Correlations between area under curve of time-glucose curve of oral glucose tolerance test and perinatal outcomes in multiparas with gestational diabetes mellitus

1.
Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210004
2.
Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210036

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Received Date: July 20, 2021
Available Online: October 27, 2021
Published Date: October 14, 2021

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Abstract

Abstract

Objective To explore the correlations between the area under curve (AUC) of time-glucose curve of oral glucose tolerance test (OGTT) and perinatal outcomes in multiparas with gestational diabetes mellitus (GDM).
Methods Totally 551 GDM multiparas with single fetus were selected, and they were divided into AUC ≤ 15.59 mmol/(L·h) group, AUC>15.60 to 16.79 mmol/(L·h) group, AUC>16.79 to 17.67 mmol/(L·h) group and AUC>17.67 mmol/(L·h) group. Correlations between AUC and adverse perinatal outcomes were analyzed in GDM multiparas.
Results There were significant differences in age and gestational weeks of delivery among the four groups (P < 0.05). There were no significant differences in the incidence rates of preterm delivery, premature rupture of membranes, abnormal amniotic fluid, cesarean section and postpartum hemorrhage among the four groups (P>0.05). The average birth weight of newborns in the AUC ≤ 15.59 mmol/(L·h) group was significantly higher than that in the AUC>15.59 to 16.79 mmol/(L·h) group (P < 0.05). There was significant difference in the incidence of neonates transferring to department of pediatrics among the AUC ≤ 15.59 mmol/(L·h) group, AUC>16.79 to 17.67 mmol/(L·h) group and AUC>17.67 mmol/(L·h) group (P < 0.05). Logistic binary regression analysis showed that AUC was significantly correlated with the incidence of neonates transferring to department of pediatrics in GDM pregnant women (P < 0.05).
Conclusion AUC of OGTT time-glucose curve in GDM multiparas can be used as an index for evaluation of blood glucose level, and it has a certain value in predicting the incidence of neonates transferring to department of pediatrics.
- multiparas,
- gestational diabetes mellitus,
- oral glucose tolerance test,
- area under curve,
- perinatal outcomes

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[1]	American Diabetes Association. 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2021[J]. Diabetes Care, 2021, 44(Suppl 1): S200-S210. http://www.ncbi.nlm.nih.gov/pubmed/30559233
[2]	PERAK A M, LANCKI N, KUANG A, et al. Associations of gestational cardiovascular health with pregnancy outcomes: the Hyperglycemia and Adverse Pregnancy Outcome study[J]. Am J Obstet Gynecol, 2021, 224(2): e1-e17.
[3]	METZGER B E, COUSTAN D R, TRIMBLE E R. Hyperglycemia and Adverse Pregnancy Outcomes[J]. Clin Chem, 2019, 65(7): 937-938. doi: 10.1373/clinchem.2019.303990
[4]	Group HSCR, METZGER B E, LOWE L P, et al. Hyperglycemia and adverse pregnancy outcomes[J]. N Engl J Med, 2008, 358(19): 1991-2002. doi: 10.1056/NEJMoa0707943
[5]	胡君, 葛智娟, 陆婧, 等. 妊娠期糖尿病对产妇远期健康的影响[J]. 中华糖尿病杂志, 2018, 10(12): 810-812. doi: 10.3760/cma.j.issn.1674-5809.2018.12.011
[6]	ACOG Practice Bulletin. Pregestational diabetes mellitus[J]. Trends Endocrinol Metabol, 2018, 10(5): 179-182.
[7]	GADGIL M D, OZA-FRANK R, KANDULA N R, et al. Type 2 diabetes after gestational diabetes mellitus in South Asian women in the United States[J]. Diabetes Metab Res Rev, 2017, 33(5): 1002. http://www.onacademic.com/detail/journal_1000039779630710_ed62.html
[8]	D'SOUZA R, HORYN I, PAVALAGANTHARAJAH S, et al. Maternal body mass index and pregnancy outcomes: a systematic review and metaanalysis[J]. Am J Obstet Gynecol MFM, 2019, 1(4): 100041. doi: 10.1016/j.ajogmf.2019.100041
[9]	International Association of Diabetes in Pregnancy Study Group Working Group on Outcome, FEIG D S, CORCOY R, et al. Diabetes in pregnancy outcomes: a systematic review and proposed codification of definitions[J]. Diabetes Metab Res Rev, 2015, 31(7): 680-90. doi: 10.1002/dmrr.2640
[10]	FERNANDEZ-TWINN D S, HJORT L, NOVAKOVIC B, et al. Intrauterine programming of obesity and type 2 diabetes[J]. Diabetologia, 2019, 62(10): 1789-1801. doi: 10.1007/s00125-019-4951-9
[11]	FRANZAGO M, FRATICELLI F, STUPPIA L, et al. Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child[J]. Epigenetics, 2019, 14(3): 215-235. doi: 10.1080/15592294.2019.1582277
[12]	SHAN D, QIU P Y, WU Y X, et al. Pregnancy outcomes in women of advanced maternal age: a retrospective cohort study from China[J]. Sci Rep, 2018, 8(1): 12239. doi: 10.1038/s41598-018-29889-3
[13]	黎丹, 黄剑青, 张兵, 等. 二胎政策开放后对高龄经产妇妊娠特征及妊娠结局的影响[J]. 中国妇幼卫生杂志, 2019(01): 51-53, 56. https://www.cnki.com.cn/Article/CJFDTOTAL-YZWS201901013.htm
[14]	BLUE E K, BALLMAN K, BOYLE F, et al. Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats[J]. Pediatr Res, 2015, 77(2): 316-25. doi: 10.1038/pr.2014.185
[15]	陶朝慧, 喻晓燕. 妊娠期糖尿病患者血糖控制效果对妊娠结局的影响[J]. 中国妇幼保健, 2017, 32(7): 1426-1429. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201707026.htm
[16]	罗赛赛. 妊娠期糖尿病患者血糖控制不良对母婴妊娠结局的影响[J]. 中国妇幼保健, 2021, 36(14): 3243-3245. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202114025.htm
[17]	王智. 孕妇血清妊娠相关蛋白、胰岛素抵抗指数与妊娠期糖尿病的关系[J]. 实用临床医药杂志, 2018, 22(11): 69-71. doi: 10.7619/jcmp.201811019
[18]	孙军萍, 黎宗保, 韩耀光, 等. 妊娠糖尿病患者血清Omentin-1、IRS-1、IRS-2与胰岛素抵抗的关系[J]. 中国妇产科临床杂志, 2020, 21(1): 83-84. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC202001033.htm
[19]	丁武华, 陈丽萍, 王淑沂. 胰岛素不同注射方式对妊娠糖尿病患者疗效的比较[J]. 实用临床医药杂志, 2014, 18(12): 93-94. doi: 10.7619/jcmp.201412030
[20]	KIM J Y, COLETTA D K, MANDARINO L J, et al. Glucose response curve and type 2 diabetes risk in Latino adolescents[J]. Diabetes Care, 2012, 35(9): 1925-30. doi: 10.2337/dc11-2476
[21]	MORBIDUCCI U, DI BENEDETTO G, GAETANO L, et al. Predicting the metabolic condition after gestational diabetes mellitus from oral glucose tolerance test curves shape[J]. Ann Biomed Eng, 2014, 42(5): 1112-20. doi: 10.1007/s10439-014-0979-7

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Correlations between area under curve of time-glucose curve of oral glucose tolerance test and perinatal outcomes in multiparas with gestational diabetes mellitus

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