Objective To investigate the value of miRNA-93 in early diagnosis of patients with type 2 diabetes mellitus (T2DM) complicated with acute myocardial infarction (AMI).
Methods A total of 147 hospitalized T2DM patients with chest pain from October 2018 to January 2021 in Department of Cardiovascular Medicine in Suqian Hospital Affiliated to Xuzhou Medical University were collected, and all the patients were divided into AMI group (n=76) and non-AMI group (n=71) after coronary angiography. The general clinical materials and the cardiac troponin I (cTnI) level within 6 h after onset were collected. Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was used to detect the serum expression level of miRNA-93 within 6 h after onset in patients. Receiver operator characteristic (ROC) curve was drawn to evaluate the value of miRNA-93 in the early diagnosis of T2DM complicated with AMI. Multivariate Logistic regression model was used to analyze the risk factors of T2DM patients complicated with AMI.
Results There were significant differences in ratio of male cases, history of smoking, history of hypertension, low density lipoprotein cholesterol (LDL-C), cTnI and miRNA-93 between the two groups (P < 0.05). The results showed that the area under the curve (AUC) of miRNA-93 in predicting AMI was 0.884, which was significantly higher than 0.786 of cTnI (P < 0.05). Multivariate Logistic regression analysis showed that miRNA-93 and history of smoking were the independent risk factors for AMI (OR=3.285, 1.864, P < 0.05).
Conclusion The miRNA-93 has a good value in early diagnosis of T2DM patients complicated with AMI. As an independent risk factor for AMI in T2DM patients, miRNA-93 may be involved in the pathophysiological process of AMI in T2DM patients.
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