Advance Search
PENG Yaozong, PENG Yuming, YIN Yiwei. Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 113-118. DOI: 10.7619/jcmp.20213049
Citation: PENG Yaozong, PENG Yuming, YIN Yiwei. Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 113-118. DOI: 10.7619/jcmp.20213049
shu

Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology

  • 1.

    Department of Radiology, Hunan Children's Hospital, Changsha, Hunan, 410007

  • 2.

    the First Department of General Surgery, Hunan Children's Hospital, Changsha, Hunan, 410007

More Information
  • Received Date: July 28, 2021
  • Available Online: April 13, 2021
  • Published Date: January 27, 2022
    Graphical Abstract
    • Abstract
  •   Objective  To evaluate the survival situations of children with rhabdomyosarcoma (RMS) after chemotherapy predicted by three-dimensional radiology.
      Methods  A total of 66 patients with RMS who received chemotherapy were retrospectively analyzed. Four methods were used to measure the tumor size on magnetic resonance or computed tomography images before and after chemotherapy. Maximal diameter was measured with Response Evaluation Criteria in Solid Tumors (1D-RECIST); multiplying the two maximal diameters was calculated with World Health Organization (2D-WHO); multiplying the three maximal diameters was calculated with European pediatric soft tissue sarcoma Study Group (3D-EpSSG); a software-assisted volume assessment was measured with the 3D-Osirix. Patients were classified as responders or non-responders based on the proposed thresholds for each method. Tumor response was compared with survival using Kaplan-Meier plots, the log-rank test, and Cox's regression.
      Results  Kaplan-Meier results showed that among the three methods, 5-year event free survival (5y-EFS) responders were longer than non-responders, and the difference of 3D-EpSSG evaluation between responder and non-responder was better than 1D-RECIST or 2D-WHO (P1D-RECIST=0.018, P2D-WHO=0.007, P3D-EpSSG and P3D-OsiriX < 0.001). In terms of 5y-EFS between the two groups, the adjusted hazard ratio of 1D-RECIST was 3.57 (P=0.016), 5.05 for 2D-WHO (P=0.004), 14.40 for 3D-EpSSG (P < 0.001), and 11.60 for 3D-Osirix (P < 0.001).
      Conclusion  Early tumor response is confirmed as a significant prognostic factor in RMS, and 3D-EpSSG and 3D-Osirix methods are superior to 1D-RECIST and 2D-WHO in predicting survival after chemotherapy for RMS.
    • FullText(HTML)
    • References (23)
  • [1]
    BHAMBHVANI H P, ZAMORA A, SHKOLYAR E, et al. Development of robust artificial neural networks for prediction of 5-year survival in bladder cancer[J]. Urologic Oncology, 2020, 39(3): 7-12.
    [2]
    KERIN Û, WOLOHAN C, COOKE K. Rhabdomyosarcoma: an overview and nursing considerations[J]. Br J Nurs, 2018, 27(6): 328-332. doi: 10.12968/bjon.2018.27.6.328
    [3]
    ANTONI A J, WAGNER L M. Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors[J]. Cancers, 2021, 13(14): 3531-3536. doi: 10.3390/cancers13143531
    [4]
    夏天, 姚伟, 沈剑, 等. 单中心儿童横纹肌肉瘤临床特征及与预后相关性168例回顾性队列研究[J]. 中华小儿外科杂志, 2021, 42(8): 736-744. doi: 10.3760/cma.j.cn421158-20210421-00203
    [5]
    徐艳丽. 儿童横纹肌肉瘤预后因素分析[J]. 中国小儿血液与肿瘤杂志, 2017, 22(5): 272-276. doi: 10.3969/j.issn.1673-5323.2017.05.012
    [6]
    文圆, 张伟令, 张谊, 等. 儿童头颈部横纹肌肉瘤疾病进展的危险因素及预后分析[J]. 中华实用儿科临床杂志, 2021, 36(15): 1152-1156. doi: 10.3760/cma.j.cn101070-20210128-00124
    [7]
    张琳, 熊昊, 李建新, 等. 儿童横纹肌肉瘤预后模型的构建及验证[J]. 临床肿瘤学杂志, 2021, 26(7): 622-628. doi: 10.3969/j.issn.1009-0460.2021.07.008
    [8]
    刘燕飞, 张娜, 李娟, 等. 儿童骨外尤文肉瘤误诊病例临床病理分析[J]. 中华实用儿科临床杂志, 2020, 35(21): 1651-1655. doi: 10.3760/cma.j.cn101070-20191018-01014
    [9]
    周恒花, 汪洋, 李江, 等. 15例头颈部梭形细胞/硬化性横纹肌肉瘤的临床病理分析[J]. 中国口腔颌面外科杂志, 2019, 17(2): 181-185. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGKQ201902029.htm
    [10]
    EISENHAUER E A, THERASSE P, BOGAERTS J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1. 1)[J]. Eur J Cancer, 2009, 45(2): 228-247. doi: 10.1016/j.ejca.2008.10.026
    [11]
    韩秀鑫, 张超, 陶芳, 等. 尤文肉瘤的治疗研究进展[J]. 重庆医学, 2019, 48(7): 1191-1195. https://www.cnki.com.cn/Article/CJFDTOTAL-CQYX201907027.htm
    [12]
    周莉, 方拥军, 芮耀耀, 等. 儿童横纹肌肉瘤临床治疗评估[J]. 临床儿科杂志, 2018, 36(8): 584-586. doi: 10.3969/j.issn.1000-3606.2018.08.004
    [13]
    SINGHAL S, GILL M, SRIVASTAVA C, et al. Simplifying Tumor Volume Estimation from Linear Dimensions for Intra-Cranial Lesions Treated with Stereotactic Radiosurgery[J]. J Med Phys, 2020, 45(4): 199-205. doi: 10.4103/jmp.JMP_56_20
    [14]
    黎凡, 林维文, 官国先, 等. MRI测量原发肿瘤体积对cT3期低位直肠癌预后指导价值研究[J]. 中国实用外科杂志, 2019, 39(4): 365-369. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201904022.htm
    [15]
    GUO FQ. 3-D treatment planning system-Leksell Gamma Knife treatment planning system[J]. Medical dosimetry: official journal of the American Association of Medical Dosimetrists, 2018, 43(2): 177-183. doi: 10.1016/j.meddos.2018.03.001
    [16]
    AGHIGHI M, BOE J, ROSENBERG J, et al. Three-dimensional radiologic assessment of chemotherapy response in ewing sarcoma can be used to predict clinical outcome[J]. Radiology, 2016, 280(3): 905-915. doi: 10.1148/radiol.2016151301
    [17]
    SCHOOT R A, MCHUGH K, VAN RIJN R R, et al. Response assessment in pediatric rhabdomyosarcoma: can response evaluation criteria in solid tumors replace three-dimensional volume assessments[J]. Radiology, 2013, 269(3): 870-878. doi: 10.1148/radiol.13122607
    [18]
    DANTONELLO T M, STARK M, TIMMERMANN B, et al. Tumour volume reduction after neoadjuvant chemotherapy impacts outcome in localised embryonal rhabdomyosarcoma[J]. Pediatr Blood Cancer, 2015, 62(1): 16-23. doi: 10.1002/pbc.25207
    [19]
    CHUNG M H, GUPTA R K, HSUEH E, et al. Humoral immune response to a therapeutic polyvalent cancer vaccine after complete resection of thick primary melanoma and sentinel lymphadenectomy[J]. J Clin Oncol, 2003, 21(2): 313-319. doi: 10.1200/JCO.2003.10.068
    [20]
    EWIJK R V, VAARWERK B, BREUNIS W B, et al. The Value of Early Tumor Size Response to Chemotherapy in Pediatric Rhabdomyosarcoma[J]. Cancers, 2021, 13(3): 510-518. doi: 10.3390/cancers13030510
    [21]
    丁敏, 刘凌翔. 晚期软组织肉瘤的免疫治疗进展[J]. 实用临床医药杂志, 2019, 23(17): 1-5. doi: 10.7619/jcmp.201917001
    [22]
    GALLAMINI A, HUTCHINGS M, RIGACCI L, et al. Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: a report from a joint Italian-Danish study[J]. J Clin Oncol, 2007, 25(24): 3746-3752. doi: 10.1200/JCO.2007.11.6525
    [23]
    刘江华, 毛彦娜, 李彦格, 等. 36例儿童横纹肌肉瘤疗效分析[J]. 现代肿瘤医学, 2019, 27(9): 1598-1601. doi: 10.3969/j.issn.1672-4992.2019.09.031
    • Related Articles

  • Cited by

    Periodical cited type(19)

    1. 安应飞，张安生，党薇，裴金莹，郭莉. 预成纤维桩在口腔修复患者中的应用效果及对牙周环境、修复成功率的影响. 临床医学研究与实践. 2024(23): 17-20 .
    2. 王雪，安民. 纤维桩树脂核冠修复上颌前磨牙缺损临床效果及抗折性能研究. 陕西医学杂志. 2023(02): 180-183 .
    3. 李晓红，谌刚龙，巴晓晔. 预成纤维桩在口腔修复中的应用效果及对咀嚼功能、牙周健康的影响. 临床医学研究与实践. 2023(17): 77-81 .
    4. 卢勇士. 不同方案治疗前牙残根Ⅴ类缺损的临床疗效观察. 中国现代药物应用. 2023(14): 47-49 .
    5. 田东源，李娜，丁丽. 金属桩口腔修复与预成纤维桩口腔修复临床疗效及安全性的对比分析. 贵州医药. 2023(10): 1554-1555 .
    6. 王巍，徐小川，詹妮. 不同桩核材料联合氧化锆全瓷冠修复前牙牙体缺损的美学效果对比. 中国美容医学. 2023(12): 128-131 .
    7. 刘学军，樊牮，赵雪，付东杰. 预成纤维桩对口腔修复患者牙周指数及MMP水平的影响. 临床口腔医学杂志. 2022(05): 299-302 .
    8. 李新玲. 金属桩与预成纤维桩应用于口腔修复对比研究. 黑龙江医药科学. 2022(04): 189-190 .
    9. 蔡萍，吴亚娟，张祥. 玻璃纤维桩修复牙体缺损患者的综合效果分析. 中国美容医学. 2022(08): 129-133 .
    10. 张昕，潘冬梅，宋丹丹. 预成纤维桩与可塑纤维桩在口腔修复中的应用安全性及有效性比较. 当代医学. 2022(21): 149-151 .
    11. 陈冲，热依拉·艾克兰木，冷春涛，郭涛. 即刻种植及残根保存修复治疗前牙残根Ⅴ类缺损的疗效观察. 口腔颌面修复学杂志. 2022(05): 337-341 .
    12. 祁东. 预成纤维桩与可塑纤维桩在口腔修复中的疗效及安全性分析. 中国现代药物应用. 2022(24): 67-70 .
    13. 罗红涛. 不同口腔修复材料在牙齿缺失患者中的应用分析. 黑龙江医学. 2021(06): 583-585 .
    14. 王玫，毛玉虎，钱君荣. 预成纤维桩在口腔修复中的应用进展. 医学综述. 2021(08): 1591-1595 .
    15. 张冲. 传统金属桩、预成纤维桩和可塑纤维桩在口腔修复中的临床应用效果研究. 现代医药卫生. 2020(05): 746-748 .
    16. 伍思俊，黎日照. 预成纤维桩在口腔修复中的临床效果评价探究. 名医. 2020(12): 32-33 .
    17. 南骏翔，葛子. 儿童牙体缺损采取不同的修复方法及疗效分析. 中国继续医学教育. 2020(21): 130-132 .
    18. 孟倩，李沙沙. 预成纤维桩或可塑纤维桩在口腔修复中的应用效果探究. 中国实用医药. 2020(32): 82-84 .
    19. 曲波. 预成纤维桩用于老年牙体缺损患者口腔修复临床效果评估. 中国药物与临床. 2020(22): 3760-3762 .

    Other cited types(1)

Catalog

    Get Citation
    PDF
    XML
    Article views (231) PDF downloads (2) Cited by(20)
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return