Effect of Yishen Cupai Recipe in treatment of patients with polycystic ovary syndrome differentiated as type of renal deficiency with phlegm and stasis

  Objective  To explore the clinical effect of Yishen Cupai Recipe in treatment of patients with polycystic ovary syndrome (PCOS) differentiated as type of renal deficiency with phlegm and stasis.

  Methods  A total of 72 patients with PCOS differentiated as type of renal deficiency with phlegm and stasis were selected and randomly divided into treatment group and control group,with 36 cases in each group.The treatment group was treated with Yishen Cupai Recipe,and the control group was treated with metformin.Ferriman-Gallwey hairy grade score,Global Acne Grading System (GAGS) score,syndrome score of traditional Chinese medicine,body mass index (BMI),laboratory indexesfollicle stimulating hormone (FSH),luteinizing hormone (LH),ratio of luteinizing hormone to follicle stimulating hormone (LH/FSH),testosterone (T),insulin resistance index (HOMA-IR) and total effective rate were compared between the two groups.

  Results  After treatment,the BMI in both groups decreased significantly,and the BMI of the treatment group was significantly lower than that of the control group (P<0.05).After treatment,the FSH increased significantly while the LH,LH/FSH,T and HOMA-IR decreased significantly in both groups,and the FSH in the treatment group was significantly higher than that in the control group,while the LH,LH/FSH,T and HOMA-IR were significantly lower than those in the control group (P<0.01).After treatment,the Ferriman-Gallwey hairy grade score,GAGS score and syndrome score of traditional Chinese medicine decreased significantly in both groups,and these indexes in the treatment group were significantly lower than those in the control group (P<0.05 or P<0.01).The total effective rate of the treatment group was 97.22%,which was significantly higher than 88.89% of the control group (P=0.037).

  Conclusion  Yishen Cupai Recipe is effective in the treatment of patients with PCOS differentiated as type of renal deficiency with phlegm and stasis,which can not only improve BMI and laboratory indexes,but also alleviate symptoms such as acne and hairiness.