Clinical value of calcification scores of coronary artery CT angiography in evaluating coronary artery lesions and prognosis in patients with chronic angina pectoris

SHEN Qin; ZHANG Xiao; WU Ting; CHEN Liang

doi:10.7619/jcmp.20213903

Journal of Clinical Medicine in Practice > 2022 > 26(3): 1-4, 8. > DOI: 10.7619/jcmp.20213903

SHEN Qin, ZHANG Xiao, WU Ting, CHEN Liang. Clinical value of calcification scores of coronary artery CT angiography in evaluating coronary artery lesions and prognosis in patients with chronic angina pectoris[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 1-4, 8. DOI: 10.7619/jcmp.20213903

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Clinical value of calcification scores of coronary artery CT angiography in evaluating coronary artery lesions and prognosis in patients with chronic angina pectoris

SHEN Qin¹,
ZHANG Xiao¹,
WU Ting¹,
CHEN Liang^{1, 2, ,}

1.
Department of Cardiovascular Medicine, the 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Wuxi, Jiangsu, 214000
2.
the 904th Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214000

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Received Date: September 28, 2021
Available Online: March 10, 2022
Published Date: February 14, 2022

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Abstract

Abstract

Objective To explore the calcification scores of coronary artery CT angiography (CTA) in evaluating coronary artery lesions and prognosis in patients with chronic angina pectoris (CAP).
Methods A total of 160 patients with CAP in our hospital were collected and received the examinations of intravascular artery ultrasound (IVUS) and CTA. Regarding the coronary IVUS as golden standard, the accuracy of the calcification scores of coronary CTA in evaluating the stability of coronary plaque was analyzed. The correlation of calcification scores of coronary CTA with stability of coronary plaque was analyzed by Pearson linear correlation analysis. Multivariate Logistic regression analysis was used to determine the risk factors for acute coronary syndrome (ACS) in CAP patients at 12 months of follow-up. The receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of calcification score of coronary artery CTA for CAP patients with ACS at 12-month of follow-up.
Results The occurrences of lipid plaques and fibrous plaque showed no significant difference between two examinations (P>0.05). However, the detection result of calcification score of coronary CTA on calcified plaque was better than that of coronary IVUS (P=0.004). Using IVUS as the gold standard, the sensitivity, specificity, positive predictive value and negative predictive value of calcification score of coronary artery CTA for the diagnosis of coronary artery vulnerable plaques were 81.4%, 69.4%, 42.9% and 92.9%, respectively. Pearson correlation analysis showed that coronary artery CTA calcification score was positively correlated with plaque stability (P < 0.05). Multivariate Logistic regression analysis showed that plaque nature and calcification score of coronary artery CTA were the influencing factors for ACS in CAP patients after followed-up for 12 months (OR=2.872, 0.559, P=0.020, 0.012). ROC curve showed that the cut-off value of CTA calcification score was 385.5, and the area under the curve to predict the occurrence of ACS in CAP patients during the follow-up of 12 months was 0.849, the sensitivity was 87.4%, and the specificity was 79.2%.
Conclusion The calcification scores of coronary CTA can assess the stability of coronary plaque, and has higher accuracy in evaluating short-term prognosis of patients with CAP.
- chronic angina pectoris,
- intravascular ultrasound of coronary artery,
- coronary artery CT angiography,
- plaque properties,
- prognosis

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References (17)

References

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Clinical value of calcification scores of coronary artery CT angiography in evaluating coronary artery lesions and prognosis in patients with chronic angina pectoris