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ZHONG Mingwei, YIN Rui. Study on inactivation effect of quaternary ammonium salts disinfectant concentrate and quaternary ammonium salts disinfectant wipes on severe acute respiratory syndrome coronavirus-2[J]. Journal of Clinical Medicine in Practice, 2021, 25(23): 9-12. DOI: 10.7619/jcmp.20214103
Citation: ZHONG Mingwei, YIN Rui. Study on inactivation effect of quaternary ammonium salts disinfectant concentrate and quaternary ammonium salts disinfectant wipes on severe acute respiratory syndrome coronavirus-2[J]. Journal of Clinical Medicine in Practice, 2021, 25(23): 9-12. DOI: 10.7619/jcmp.20214103
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Study on inactivation effect of quaternary ammonium salts disinfectant concentrate and quaternary ammonium salts disinfectant wipes on severe acute respiratory syndrome coronavirus-2

  • Research and Development Department, Hangzhou Hygen Health Biotechnology Co., Ltd., Hangzhou, Zhejiang, 310018

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  • Received Date: October 19, 2021
  • Available Online: December 20, 2021
  • Published Date: December 14, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To study the inactivation effect of QUAT disinfectant concentrate and QUAT disinfectant wipes on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
      Methods  The suspension quantitative killing test method was used to analyze the effect of the QUAT disinfectant concentrate and QUAT disinfectant wipes in inactivating the SARS-CoV-2.
      Results  The main ingredients of the QUAT disinfectant concentrate and QUAT disinfectant wipes were four single and double-chain quaternary ammonium salts mixtures, and the inactivation log value of novel coronavirus SARS-CoV-2 in suspension was greater than 4.0 when the concentration was 432 mg/L and the action time was 1 min. The squeezed solution of the QUAT disinfectant wipes prepared with the QUAT disinfectant concentrate had a concentration of 820 mg/L, the logarithmic value of inactivation of the SARS-CoV-2 in the suspension was greater than 4.0 when the action time was 1 min.
      Conclusion  The QUAT disinfectant concentrate and QUAT disinfectant wipes can quickly and effectively inactivate the SARS-CoV-2 at low concentrations.
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    • References (16)
  • [1]
    国务院应对新型冠状病毒肺炎疫情联防联控机制综合组. 关于印发新型冠状病毒肺炎防控方案(第八版)的通知[EB/OL]. (2021-05-21)[2021-10-18]. http://www.nhc.gov.cn/xcs/zhengcwj/202105/6f1e8ec6c4a540d99fafef52fc86d0f8.shtml.
    [2]
    VAN DOREMALEN N, BUSHMAKER T, MORRIS D H, et al. Aerosol and surface stability of HCoV-19(SARS-CoV-2) compared to SARS-CoV-1[J]. medRxiv, 2020, 3(9): 20033217. http://www.researchgate.net/publication/339917826_Aerosol_and_surface_stability_of_HCoV-19_SARS-CoV-2_compared_to_SARS-CoV-1
    [3]
    中华人民共和国卫生部. 卫生部关于印发《消毒技术规范》(2002年版)的通知[EB/OL]. (2002-11-15)[2021-10-18]. http://www.nhc.gov.cn/wjw/gfxwj/201304/3a0121cba422455b93307f070b099cf2.shtml.
    [4]
    British Standards Institution(BSI). EN 14476-2015 Chemical disinfectants and antiseptics-Quantitative suspension test for the evaluation of virucidal activity in the medical area-Test method and requirements[S]. British: BSI Standards Limited, 2015.
    [5]
    王立钦, 刘文丽, 刘振东, 等. 一种复合型皮肤消毒剂对冠状病毒灭活效果的观察[J]. 中国消毒学杂志, 2020, 37(8): 580-582. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXD202008008.htm
    [6]
    王嘉军. 蜂胶-银离子复合纳米乳剂的研制及其生物活性的检测[D]. 北京: 中国人民解放军军事医学科学院, 2006.
    [7]
    国家卫生和计划生育委员会. 医疗机构环境表面清洁与消毒管理规范: WS/T 512-2016[S]. 北京: 中国标准出版社, 2017.
    [8]
    中华人民共和国卫生部. 医疗机构消毒技术规范: WS/T 367-2012[S]. 北京: 中国标准出版社, 2012.
    [9]
    段达荣, 蔡莎莎, 朱晔晶, 等. 三种消毒剂对重症监护病房物体表面耐碳青霉烯类肠杆菌消毒效果比较[J]. 中国消毒学杂志, 2019, 36(3): 231-233. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXD201903025.htm
    [10]
    江云兰, 鲁梅丽, 马红秋, 等. 双链季铵盐消毒剂对医院物体表面消毒效果研究[J]. 中华医院感染学杂志, 2015, 25(11): 2623-2625. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201511081.htm
    [11]
    SINGH M, SHARMA R, GUPTA P K, et al. Comparative efficacy evaluation of disinfectants routinely used in hospital practice: India[J]. Indian J Crit Care Med, 2012, 16(3): 123-129. doi: 10.4103/0972-5229.102067
    [12]
    黄蔷薇, 叶白如, 金茹, 等. 医用消毒湿巾对血透机表面消毒效果的研究[J]. 中国消毒学杂志, 2016, 33(1): 94-95. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXD201601039.htm
    [13]
    康秀华, 何海燕, 阳秀英. 复合双链季胺盐消毒湿巾在ICU仪器消毒中的应用效果观察[J]. 中国消毒学杂志, 2019, 36(6): 434-435, 438. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXD201906011.htm
    [14]
    程伊莲, 郑蜀芳, 石明国, 等. 新型冠状病毒肺炎疫情期不同消毒方法对肺炎专用CT机的消毒效果分析[J]. 中国医疗设备, 2020, 35(6): 16-18, 30. doi: 10.3969/j.issn.1674-1633.2020.06.005
    [15]
    LI J, XIE Y C, LI W H, et al. Synthesis and inhibition behavior of the quaternary ammonium salt-type tetrameric surfactant for corrosion of N80 steel in HCl medium[J]. Prot Met Phys Chem Surf, 2019, 55(4): 789-794. doi: 10.1134/S2070205119040117
    [16]
    郭瑞娟, 赵凤, 汤文丽, 等. 自制一次性消毒湿巾对手术室物体表面的消毒效果及对操作依从性的影响[J]. 临床医学研究与实践, 2020, 5(12): 150-152. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202012058.htm
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