Infection of human papillomavirus and gene subtypes distribution in 56 434 female patients

  Objective  To investigate the positive infection of human papillomavirus (HPV) in a hospital in Yangzhou of Jiangsu Province, and provide references for HPV prevention and control strategy as well as selection of vaccine.

  Methods  The cervical epithelial cell samples from 56 434 women from January 2018 to December 2020 were selected, and 37 HPV subtypes were tested by gene amplification and diversion hybrid.

  Results  A total of 12 900 HPV positive samples were detected, with a positive rate of 22.86%(12 900/56 434), among which single infection(mainly high-risk HPV subtypes infection) accounted for 77.35%, and multiple infections(mainly high-risk and low-risk HPV subtypes infection) for 22.65%. A total of 36 subtypes of HPV were detected, HPV 52, HPV16, HPV58, HPV53 and HPV51 ranked the top five in detection rate. The detection rate of HPV infection was the highest in women aged 26 to 35 (25.07%), followed by women aged 36 to 45 (24.45%) and women aged 46 to 55 (20.96%).

  Conclusion  HPV positive Females in Yangzhou Maternal and Child Health Care Hospital of Jiangsu Province from 2018 to 2020 are mainly infected by single and high risk subtypes, HPV 52, HPV16, HPV58, HPV53 and HPV 51 gene subtypes are commonly seen. Therefore, HPV vaccines for these 5 subtypes should be selected for women in Yangzhou.