Controversy and significance of vascular mimicry in malignant tumors

SHI Xin; CHEN Jue

doi:10.7619/jcmp.20214931

Journal of Clinical Medicine in Practice > 2022 > 26(3): 139-143. > DOI: 10.7619/jcmp.20214931

SHI Xin, CHEN Jue. Controversy and significance of vascular mimicry in malignant tumors[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 139-143. DOI: 10.7619/jcmp.20214931

Citation:

SHI Xin, CHEN Jue. Controversy and significance of vascular mimicry in malignant tumors[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 139-143. DOI: 10.7619/jcmp.20214931

Citation:

SHI Xin, CHEN Jue. Controversy and significance of vascular mimicry in malignant tumors[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 139-143. DOI: 10.7619/jcmp.20214931

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Controversy and significance of vascular mimicry in malignant tumors

SHI Xin¹,
CHEN Jue^2, ,

1.
Department of Oncology, the Second People's Hospital of Taizhou City Affiliated to Medical College of Yangzhou University, Taizhou, Jiangsu, 225500
2.
Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225000

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Received Date: December 14, 2021
Available Online: March 10, 2022
Published Date: February 14, 2022

Graphical Abstract

Abstract

Abstract

Vascular mimicry (VM) refers to a tubular structure with oxygen supply and blood circulation functions, which is independently formed by tumor cells in solid tumors. Since it was proposed by Professor Hendrix of Ohio State University in 1999, its function, structure and clinical significance have been controversial. Nevertheless, many academic studies still tend to believe that this tubular structure conforms to the morphological and functional characteristics of blood vessels. Because VM simulates the process of vascular endothelial cells forming blood vessels, the role of many signals involved in endothelial cell-dependent angiogenesis in VM formation has also been concerned and studied. This paper summarized the relevant controversial issues in the recent VM researches.
- vascular mimicry,
- tumor,
- matrix metalloproteinase,
- vascular endothelial growth factor,
- anti-angiogenesis,
- signaling pathway

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References (49)

References

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