| Citation: |
CAO Li, XU Baida, YE Ting, LIU Jie, AN Dongmei. Correlation between gender difference and impaired coronary flow reserve in patients with type 2 diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2022, 26(10): 43-46. DOI: 10.7619/jcmp.20215085
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To investigate the gender difference of impaired coronary flow reserve (CFR) in patients with type 2 diabetes mellitus.
A total of 201 patients with type 2 diabetes mellitus (excluding patients with obstructive coronary heart disease) were selected as research objects, and divided into male group (n=97) and female group (n=104).Differences in CFR and clinical indexs of the two groups were analyzed; the risk factors of CFR in type 2 diabetes patients were analyzed by multivariate Logistic analysis; the correlations between clinical indicators and CFR were evaluated by Pearson linear correlation analysis.
CFR of the female group was significantly lower than that of the male group, and plasma aldosterone level as well as ratio of peak flow velocity in early diastolic mitral orifice to peak flow velocity in early diastolic mitral annulus doppler tissue (E/e') were significantly higher than those of the male group (P < 0.05).Female is risk factor associated with CFR in diabetes (OR=3.219, P=0.018), while low aldosterone level and low E/e'were protective factors associated with CFR in diabetes (OR=0.568, P=0.032;OR=0.372, P=0.012).Plasma aldosterone level was negatively correlated with CFR (OR=-0.683, P=0.035), E/e'was negatively correlated with CFR (OR=-0.751, P=0.023).
CFR is significantly impaired in female patients with type 2 diabetes than in males, and the increase of plasma aldosterone level and E/e'in females may be one of causes of CFR impairment in female.
| [1] |
DÖRR O, LIEBETRAU C, WEFERLING M, et al. Fractional flow reserve and frequency of PCI in patients with coronary artery disease[J]. Herz, 2020, 45(8): 752-758. doi: 10.1007/s00059-019-04848-4
|
| [2] |
WU K Y, TIMMERMAN N P, MCPHEDRAN R, et al. Differential association of diabetes mellitus and female sex with impaired myocardial flow reserve across the spectrum of epicardial coronary disease[J]. Eur Heart J Cardiovasc Imaging, 2020, 21(5): 576-584. doi: 10.1093/ehjci/jez163
|
| [3] |
JVRGENS M, SCHOU M, HASBAK P, et al. Effects of empagliflozin on myocardial flow reserve in patients with type 2 diabetes mellitus: the SIMPLE trial[J]. J Am Heart Assoc, 2021, 10(15): e020418. doi: 10.1161/JAHA.120.020418
|
| [4] |
MAHFOUZ R A, SEAOUD E A, ELBELBESY R A, et al. Resting left ventricular dyssynchrony and mechanical reserve in asymptomatic normotensive subjects with early type 2 diabetes mellitus[J]. Pulse (Basel), 2020, 8(1/2): 47-56.
|
| [5] |
HAAS A V, ROSNER B A, KWONG R Y, et al. Sex differences in coronary microvascular function in individuals with type 2 diabetes[J]. Diabetes, 2019, 68(3): 631-636. doi: 10.2337/db18-0650
|
| [6] |
MULVAGH S L, MOKHTAR A T. Coronary flow velocity reserve in stress echocardiography: time to go with the global flow[J]. J Am Coll Cardiol, 2019, 74(18): 2292-2294. doi: 10.1016/j.jacc.2019.08.1042
|
| [7] |
ASSANTE R, MAINOLFI C G, ZAMPELLA E, et al. Relation between myocardial blood flow and cardiac events in diabetic patients with suspected coronary artery disease and normal myocardial perfusion imaging[J]. J Nucl Cardiol, 2021, 28(4): 1222-1233. doi: 10.1007/s12350-021-02533-w
|
| [8] |
SMIT J M, EL MAHDIUI M, VAN ROSENDAEL A R, et al. Comparison of diagnostic performance of quantitative flow ratio in patients with versus without diabetes mellitus[J]. Am J Cardiol, 2019, 123(10): 1722-1728. doi: 10.1016/j.amjcard.2019.02.035
|
| [9] |
NOZUE T, TAKAMURA T, FUKUI K, et al. Assessment of factors associated with measurability of fractional flow reserve derived from coronary computed tomography angiography in type 2 diabetic patients with intermediate coronary artery Stenosis[J]. Int J Cardiovasc Imaging, 2019, 35(2): 359-365. doi: 10.1007/s10554-018-1476-0
|
| [10] |
BROWN S M, MEUTH A I, DAVIS J W, et al. Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: a unique vascular transcriptomic signature[J]. Pharmacol Res, 2018, 134: 100-108. doi: 10.1016/j.phrs.2018.06.002
|
| [11] |
IBARROLA J, SADABA R, MARTINEZ-MARTINEZ E, et al. Aldosterone impairs mitochondrial function in human cardiac fibroblasts via A-kinase anchor protein 12[J]. Sci Rep, 2018, 8(1): 6801. doi: 10.1038/s41598-018-25068-6
|
| [12] |
KATO S, FUKUI K, KODAMA S, et al. Incremental prognostic value of coronary flow reserve determined by phase-contrast cine cardiovascular magnetic resonance of the coronary sinus in patients with diabetes mellitus[J]. J Cardiovasc Magn Reson, 2020, 22(1): 73. doi: 10.1186/s12968-020-00667-3
|
| [13] |
NISHI T, SAITO Y, KITAHARA H, et al. Coronary flow reserve and glycemic variability in patients with coronary artery disease[J]. Intern Med, 2021, 60(8): 1151-1158. doi: 10.2169/internalmedicine.6158-20
|
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