Relationship between cognitive function and fibroblast growth factor-2 in patients with schizophrenia and its gender difference

XU Ying; XIAO Wenhuan; ZHAO Yilin; YANG Xiang; ZHONG Yunian

doi:10.7619/jcmp.20220046

Journal of Clinical Medicine in Practice > 2022 > 26(14): 64-69. > DOI: 10.7619/jcmp.20220046

XU Ying, XIAO Wenhuan, ZHAO Yilin, YANG Xiang, ZHONG Yunian. Relationship between cognitive function and fibroblast growth factor-2 in patients with schizophrenia and its gender difference[J]. Journal of Clinical Medicine in Practice, 2022, 26(14): 64-69. DOI: 10.7619/jcmp.20220046

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Relationship between cognitive function and fibroblast growth factor-2 in patients with schizophrenia and its gender difference

XU Ying¹,
XIAO Wenhuan¹,
ZHAO Yilin¹,
YANG Xiang^{1, 2},
ZHONG Yunian^{1, 2, ,}

1.
Department of Psychiatry, Wutaishan Hospital of Yangzhou in Jiangsu Province, Yangzhou, Jiangsu, 225003
2.
Yangzhou Mental Health Prevention and Treatment Center, Yangzhou, Jiangsu, 225003

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Received Date: January 04, 2022
Available Online: July 13, 2022

Graphical Abstract

Abstract

Abstract

Objective
To explore the relationship between fibroblast growth factor-2 (FGF-2) and cognitive function in patients with schizophrenia and its gender difference.
Methods
A total of 112 chronic schizophrenic patients were recruited as study subjects, among whom 58 females were included in female group and 54 males in male group. Stroop test, range fluency test, connection test and block diagram were used to evaluate the cognitive function of patients. The serum FGF-2 levels of patients were detected by enzyme-linked immunosorbent assay. The difference in correlation between serum FGF-2 level and cognitive function in males and females was analyzed, and the relationships of gender, FGF-2 and cognitive function were discussed through adjustment analysis.
Results
The range fluency test-animal naming score and block diagram test-spatial breadth (backward) score in the male group were lower than those in the female group (t=3.131, 2.215; P=0.002, 0.029); the serum FGF-2 level in the male group was (8.96±1.69) μg/mL, which was lower than (9.97± 2.76) μg/mL of the female group (t=2.308, P=0.023). The correlation analysis showed that the serum FGF-2 level in the female group was positively correlated with the range fluency test-animal naming score (r = 0.264, P=0.045), and negatively correlated with the connection test-B score (r=-0.401, P=0.002); there was no correlation between serum FGF-2 level and cognitive function scores in the male group(P>0.05). Adjustment analysis showed that gender had reciprocal effect on connection test-B score(β=4.373, t=2.425, P=0.017).
Conclusion
Serum FGF-2 level in schizophrenic patients is correlated with cognitive impairment, and there are gender differences. Compared with female patients, male schizophrenic patients have more severe cognitive impairment in attention memory and executive function, and lower level of serum FGF-2. The cognitive impairment of schizophrenic female may be related to the low level of serum FGF-2.
- schizophrenia,
- cognitive function,
- fibroblast growth factor-2,
- gender,
- cognitive impairment,
- sex hormone

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References (26)

References

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