Objective To explore the relationships of preoperative serum ferritin, albumin and ratio of ferritin to albumin with prognosis after hepatectomy in patients with hepatocellular carcinoma.
Methods Clinical materials of 112 patients with hepatocellular carcinoma treated by hepatectomy from January 2015 to January 2020 were retrospectively analyzed. The optimal critical value of serum ferritin, albumin and the ratio of ferritin to albumin in predicting poor prognosis was analyzed by receiver operating characteristic (ROC) curve. The patients were classified according to the critical value, and the relationships of different serum ferritin, albumin, and ratio of ferritin to albumin ratio with clinicopathological features were analyzed. Multivariate Cox proportional hazards regression was used to analyze the related factors affecting the prognosis.
Results The overall survival of 112 patients was 5 to 75 months, with an average of (53.84±6.51) months; for patients with ferritin ≥ 108.63 μg/L, albumin ≤ 41.19 g/L and the ratio of ferritin to albumin ≥ 3.42, their survival was 5 to 31 months, with an average of (28.56±3.12) months; for patients with ferritin < 108.63 μg/L, albumin>41.19 g/L and ratio of ferritin to albumin < 3.42, their survival was 12 to 75 months, with an average of (72.11±1.25) months; the differences mentioned above were statistically significant (t=101.924, P < 0.001). Preoperative serum ferritin, albumin and the ratio of ferritin to albumin were correlated with liver cirrhosis (P < 0.05). Multivariate Cox proportional hazards regression analysis showed that serum ferritin ≥ 108.63 μg/L, albumin ≤ 41.19 g/L, the ratio of ferritin to albumin ≥ 3.42 and cirrhosis were the influencing factors of poor prognosis after hepatectomy in patients with hepatocellular carcinoma.
Conclusion Preoperative serum ferritin ≥ 108.63 μg/L, albumin ≤ 41.19 g/L and ratio of ferritin to albumin ≥ 3.42 are the independent risk factors for the prognosis of patients with hepatocellular carcinoma after hepatectomy, and the increase of serum ferritin and ratio of ferritin to albumin as well as the decrease of albumin level before hepatectomy suggest poor prognosis.
DownLoad: