Objective To analyze the influencing factors of recurrence after cytoreductive surgery (CRS) in patients with ovarian cancer (OC).
Methods Data of 107 OC patients were retrospectively collected, and all patients completed CRS treatment and were followed up for 2 years. These patients were divided into recurrence group and non-recurrence group according to tumor recurrence within 2 years after surgery. Logistic regression analysis was used to investigate the influencing factors of postoperative recurrence of CRS in OC patients.
Results Among 107 OC patients, 68 patients relapsed after CRS, with a recurrence rate of 63.55%. The expression of breast cancer susceptibility gene-1 (BRCA-1), poly adenosine diphosphate ribose polymerase-1 (PARP-1), residual tumor diameter, intraoperative lymph node dissection, carbohydrate antigen 125 (CA125) level and human epididymal protein 4 (HE4) level showed significant differences between the recurrence group and the non-recurrence group (P < 0.05). Compared age, tumor diameter, International Federation of Gynecology and Obstetrics(FIGO) stage, disease type, histological type, delivery times, preoperative menopause, lymph node metastasis, proportion of tumor cells with different degrees of differentiation, serum CA199 and carcinoembryonic antigen (CEA) between recurrent and non-recurrent OC patients, there was no statistical significant difference (P>0.05). Logistic regression analysis showed that BRCA-1 positive expression, PARP-1 positive expression, residual tumor diameter >1 cm, unperformed intraoperative lymph node dissection, increased CA125 and HE4 levels might be the influencing factors of postoperative recurrence after CRS in OC patients (OR>1, P < 0.05).
Conclusion BRCA-1 positive expression, PARP-1 positive expression, residual tumor diameter >1 cm, intraoperative uncleaned lymph nodes, increased CA125 and HE4 levels may be the risk factors of postoperative recurrence after CRS in OC patients.
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