Expression of Rictor protein in tissue of colorectal cancer and its relationships with clinicopathological features and prognosis

ZHOU Yizhi; ZHANG Zhongwei; XIANG Libin; LIU Yan; WANG Shuo; CAO Meinan

doi:10.7619/jcmp.20220770

Journal of Clinical Medicine in Practice > 2022 > 26(15): 80-83, 88. > DOI: 10.7619/jcmp.20220770

ZHOU Yizhi, ZHANG Zhongwei, XIANG Libin, LIU Yan, WANG Shuo, CAO Meinan. Expression of Rictor protein in tissue of colorectal cancer and its relationships with clinicopathological features and prognosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(15): 80-83, 88. DOI: 10.7619/jcmp.20220770

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Expression of Rictor protein in tissue of colorectal cancer and its relationships with clinicopathological features and prognosis

the 962nd Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Harbin, Heilongjiang, 150086

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Received Date: March 09, 2022
Available Online: August 22, 2022

Graphical Abstract

Abstract

Abstract

Objective
To observe the expression of Rictor protein in tissue of colorectal cancer and its relationships with clinicopathological features and prognosis.
Methods
A total of 90 patients with colorectal cancer treated were collected as study objects, and colorectal cancer tissue samples were collected, and the corresponding adjacent normal colorectal tissue was selected as control. The expressions of Rictor protein in colorectal cancer tissue and adjacent normal colorectal tissue were detected by immunohistochemistry, and relationships of Rictor protein with clinicopathologic feature and prognosis were analyzed. Univariate and multivariate Cox regression analysis was used to investigate the prognostic factors of colorectal cancer patients.
Results
The expression rate of Rictor protein in colorectal cancer tissue was significantly higher than that in normal colorectal tissues[55.6%(50/90) versus 11.1%(10/90), χ²=40.034, P < 0.001]. The positive rate of Rictor protein in tissue of colorectal cancer was related to tumor diameter, depth of invasion, TNM stage, degree of differentiation and lymph node metastasis (P < 0.05). The overall survival rate of patients with low expression of Rictor protein was higher than that of those with high expression (P < 0.05). Cox regression analysis showed that high expression of Rictor protein and stage Ⅲ of TNM staging were independent risk factors for death of colorectal cancer (P < 0.05).
Conclusion
Rictor protein in colorectal cancer is highly expressed, and is associated with malignant biological behavior and poor prognosis of patients.
- colorectal cancer,
- Rictor protein,
- clinicopathological features,
- prognosis,
- lymph node metastasis,
- depth of infiltration,
- risk factors

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References (18)

References

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Expression of Rictor protein in tissue of colorectal cancer and its relationships with clinicopathological features and prognosis