Citation: | JIA Manqing, WANG Yang, CAI Jing, Liu Jun. Association between paraoxonase-1 Q192R gene polymorphism and clopidogrel resistance in patients with acute myocardial infarction[J]. Journal of Clinical Medicine in Practice, 2022, 26(16): 61-65. DOI: 10.7619/jcmp.20220834 |
To analyze the correlation between paraoxonase-1 (PON1) Q192R gene polymorphism and clopidogrel resistance in patients with acute myocardial infarction.
A total of 135 patients with acute myocardial infarction were selected as research objects. All patients were treated with standard clopidogrel for 5 consecutive days and post-discharge for 12 months continuously. After 12 months of medication, the platelet aggregation rate was measured in the hospital. Patients were divided into resistance group (aggregation rate >50%) and sensitive group (≤50%) according to platelet aggregation rate. PON1 Q192R gene polymorphism was detected by fluorescence in situ hybridization.
Platelet aggregation was determined in 135 patients with acute myocardial infarction, 103 cases (76.30%) in the sensitive group and 32 cases (23.70%) in the resistance group. The incidence rates of heterozygous and homozygous single nucleotide polymorphisms (SNP) of PON1 Q192R gene distribution in the resistance group were significantly higher than those in the sensitive group (P < 0.05). The incidence of end-point events at one year after operation in the resistance group was significantly higher than that in the sensitive group (P < 0.05). The platelet aggregation rate of adenosine diphosphate (ADP) and the incidence of major adverse cardiovascular events (MACE) in PON1 Q192R wild-type were significantly lower than those in PON1 Q192R mutant (P < 0.05). PON1 Q192R gene mutation and ADP platelet aggregation ratewere risk factors for MACE in patients with acute myocardial infarction (P < 0.05). SNP heterozygous type and SNP homozygous type of PON1 Q192R gene were significantly correlated with clopidogrel resistance (P < 0.05).
PON1 Q192R gene polymorphisms has higher correlation with clopidogrel resistance in patients with AMI.
[1] |
ZEYMER U, BUENO H, GRANGER C B, et al. Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: a document of the Acute Cardiovascular Care Association of the European Society of Cardiology[J]. Eur Heart J Acute Cardiovasc Care, 2020, 9(2): 183-197. doi: 10.1177/2048872619894254
|
[2] |
KIM C J, PARK M W, KIM M C, et al. Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised trial[J]. Lancet, 2021, 398(10308): 1305-1316. doi: 10.1016/S0140-6736(21)01445-8
|
[3] |
张晶, 刘佳, 陆康生, 等. CYP2C19、PON1-Q192R基因多态性与急性冠脉综合征患者行PCI术后抗血小板治疗药效的相关性研究[J]. 中国医院药学杂志, 2020, 40(14): 1544-1548. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYZ202014010.htm
|
[4] |
后世翔, 方存明, 栾家杰, 等. CYP2C19、ABCB1和PON1基因多态性对ACS病人PCI术后氯吡格雷治疗的影响[J]. 蚌埠医学院学报, 2021, 46(5): 606-610. https://www.cnki.com.cn/Article/CJFDTOTAL-BANG202105013.htm
|
[5] |
中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南[J]. 中华心血管病杂志, 2010, 38(8): 675-690. doi: 10.3760/cma.j.issn.0253-3758.2010.08.002
|
[6] |
BARRAGAN P, BOUVIER J L, ROQUEBERT P O, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation[J]. Catheter Cardiovasc Interv, 2003, 59(3): 295-302. doi: 10.1002/ccd.10497
|
[7] |
CHANG C J, TUNG Y C, LIU J R, et al. Efficacy and safety of ticagrelor vs. clopidogrel in east Asian patients with acute myocardial infarction: a nationwide cohort study[J]. Clin Pharmacol Ther, 2021, 109(2): 443-451. doi: 10.1002/cpt.2011
|
[8] |
王焱, 程鹏, 王大同, 等. 非致残性缺血性脑血管事件病人氯吡格雷抵抗的临床相关因素分析[J]. 安徽医药, 2021, 25(8): 1577-1581. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYY202108024.htm
|
[9] |
杨禹娟, 田刚, 王亚萍, 等. 老年冠心病患者经皮冠状动脉介入治疗后氯吡格雷抵抗与CYP2C19基因多态性的关系研究[J]. 中国心血管病研究, 2019(7): 656-660. https://www.cnki.com.cn/Article/CJFDTOTAL-SYXL201803009.htm
|
[10] |
刘佳星, 王冰, 邢继成, 等. MiR140-5p在HepG2细胞中对对氧磷酶1表达的调控及其临床应用[J]. 临床检验杂志, 2019, 37(2): 137-141. https://www.cnki.com.cn/Article/CJFDTOTAL-LCJY201902014.htm
|
[11] |
丁柏宇, 赵军礼. 冠心病人群氯吡格雷抵抗与基因多态性的研究进展[J]. 医学综述, 2020, 26(19): 3801-3805, 3813. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZS202019013.htm
|
[12] |
邓树强. 对氧磷酶-1 Q192R基因多态性与氯吡格雷治疗冠心病疗效之间相关性的研究进展[J]. 牡丹江医学院学报, 2019, 40(5): 106-109. https://www.cnki.com.cn/Article/CJFDTOTAL-MDJB201905033.htm
|
[13] |
石蕊, 卢姗, 王微, 等. PON1 Q192R基因多态性与氯吡格雷治疗的脑梗死患者复发相关性研究[J]. 中国医药导报, 2021, 18(11): 82-85. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202111021.htm
|
[14] |
戴玉洋, 李嘉静, 武峰, 等. 细胞色素P450 2C19、对氧磷酶1基因多态性与氯吡格雷抵抗的关联性研究[J]. 中国临床药理学杂志, 2019, 35(4): 334-337. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201904006.htm
|
[15] |
向乾才, 罗廷福, 张娟, 等. 氯吡格雷片联合阿司匹林肠溶片治疗急性冠状动脉综合征患者的预后与对氧磷酶1Q192R基因多态性的相关性[J]. 中国临床药理学杂志, 2021, 37(12): 1487-1490. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ202112002.htm
|
[1] | HOU Guoqing, YUE Hailong, CHANG Qian, MA Juntao. Effect of dexmedetomidine on epidural fibrosis afterspinal surgery in rats via the transforming growth factor-β1 pathway[J]. Journal of Clinical Medicine in Practice, 2025, 29(1): 77-82. DOI: 10.7619/jcmp.20243181 |
[2] | XUE Mei, LIAO Yi, LU Wei. Effects of microRNA-455-3p on airway smooth muscle cells in asthmatic rats by regulating toll-like receptor 4[J]. Journal of Clinical Medicine in Practice, 2022, 26(22): 25-32. DOI: 10.7619/jcmp.20221809 |
[3] | XIE Zhennian, AN Xiaojing, ZHOU Haiyang, WANG Fangli, WANG Liping. Effect of compound chamomile and lidocaine hydrochloride gel on skin wound healing in rats[J]. Journal of Clinical Medicine in Practice, 2022, 26(17): 18-23. DOI: 10.7619/jcmp.20222308 |
[4] | YAN Keshi, WANG Weiwei, YU Xin, LU Dahao, DAI Chen, GAO Ju. Single versus multiple administrations of metformin in treatment of rats with ventilator-induced brain injury[J]. Journal of Clinical Medicine in Practice, 2020, 24(3): 33-35. DOI: 10.7619/jcmp.202003010 |
[5] | LI Boping, LIU Xiuli, QIU Qian. Antioxidant activities of puerarin on aged rats[J]. Journal of Clinical Medicine in Practice, 2017, (7): 1-4,20. DOI: 10.7619/jcmp.201707001 |
[6] | XU Zhengxin, ZHENG Xue, ZHU Lei. Effect of osthole on sodium channels of ventricular myocytes in rat[J]. Journal of Clinical Medicine in Practice, 2016, (7): 1-5. DOI: 10.7619/jcmp.201607001 |
[7] | DING Fengzhen, TANG Keqin. Study on preventive mechanism of Danshen Injection in AP rats[J]. Journal of Clinical Medicine in Practice, 2015, (17): 1-4. DOI: 10.7619/jcmp.201517001 |
[8] | YU Ye, SHI Dij ian, CHEN Jianbo. Effects of Danhong inj ection on protection of brain in rats with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2014, (17): 5-7. DOI: 10.7619/jcmp.201417002 |
[9] | SUN Xhiguo, CAI Haifeng, WANG Xhiyun, LU Yanqin, DAI Hao. Effect of stellate ganglion block on hormone level in rats with breast hyperplasia[J]. Journal of Clinical Medicine in Practice, 2014, (9): 58-60. DOI: 10.7619/jcmp.201409016 |
[10] | XU Wei, JIN Jing. Establishing a rat model for acute radiation enteritis induced by linear accelerator[J]. Journal of Clinical Medicine in Practice, 2013, (11): 9-11. DOI: 10.7619/jcmp.201311003 |