Value of patient-reported outcome score combined with serological indicators in evaluating endoscopic disease activity of patients with Crohn's disease

HAO Xin; HU Xiaolin; WANG Mei; WU Dacheng; SUN Yunyun; HOU Sicong

doi:10.7619/jcmp.20220865

Journal of Clinical Medicine in Practice > 2022 > 26(16): 6-10. > DOI: 10.7619/jcmp.20220865

HAO Xin, HU Xiaolin, WANG Mei, WU Dacheng, SUN Yunyun, HOU Sicong. Value of patient-reported outcome score combined with serological indicators in evaluating endoscopic disease activity of patients with Crohn's disease[J]. Journal of Clinical Medicine in Practice, 2022, 26(16): 6-10. DOI: 10.7619/jcmp.20220865

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Value of patient-reported outcome score combined with serological indicators in evaluating endoscopic disease activity of patients with Crohn's disease

HAO Xin^{1, 2},
HU Xiaolin^{1, 2},
WANG Mei¹,
WU Dacheng¹,
SUN Yunyun¹,
HOU Sicong^1, ,

1.
Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225001
2.
Department of Clinical Medicine, Medical College of Yangzhou University, Yangzhou, Jiangsu, 225001

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Received Date: March 17, 2022
Available Online: August 07, 2022

Graphical Abstract

Abstract

Abstract

Objective
To analyze the value of patient-reported outcome (PRO) score combined with serological indicators in evaluating endoscopic disease activity of patients with Crohn's disease (CD).
Methods
The clinical materials of CD patients were collected, and the correlation between PRO score and Simplified Endoscopic Score for CD (SES-CD) was analyzed. According to the SES-CD result, the patients were divided into active phase group and remission phase group, the clinical materials were compared between the two groups, and the independent risk factors related to endoscopic disease activity were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the value of evaluation for endoscopic disease activity by each single index and their combination.
Results
The PRO score was slightly positively correlated with SES-CD (r=0.394, P < 0.001). The platelet (PLT), red blood cell distribution width (RDW), plateletcrit (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and PRO score of the patients in the active phase group were significantly higher than those in the remission phase group, while the lymphocyte ratio (LY), hematocrit (HCT), mean red blood cell volume (MCV), platelet distribution width (PDW), mean platelet volume (MPV) and albumin (ALB) were significantly lower than those in the remission phase group (P < 0.05 or P < 0.01). Multivariate Logistic regression analysis showed that PRO score, ESR and RDW were independent risk factors for endoscopic disease activity (P < 0.05). ROC curve showed that the sensitivity, specificity and area under the curve of PRO score combined with ESR and RDW in evaluating the endoscopic disease activity of CD patients were 80.5%, 90.0% and 0.774, respectively (P < 0.001).
Conclusion
PRO score combined with ESR and RDW can increase the prediction accuracy of endoscopic disease activity in patients with CD, and is a convenient and reliable non-invasive evaluation index.

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References (17)

References

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Value of patient-reported outcome score combined with serological indicators in evaluating endoscopic disease activity of patients with Crohn's disease