Objective To investigate the value of plasma microRNA(miR)-126 and miR-130 in predicting the prognosis of acute myocardial infarction after emergency percutaneous coronary intervention(PCI).
Methods A total of 170 patients with acute myocardial infarction treated in our hospital were selected as case group. At the same time, 60 healthy people were included in control group. The contents of plasma miR-126 and miR-130 were compared between the case group and the control group. After follow-up for 12 months, the patients were divided into short-term poor prognosis groupn=26, major adverse cardiovascular events (MACE) in post-operation 30 d and short-term good prognosis group n=144, non-MACE in post-operation 30 d, long-term poor prognosis groupn=40, MACE in post-operation 12 months and long-term good prognosis group n=130, non-MACE in post-operation 12 monthsaccording to the occurrences of MACE. The expression levels of left ventricular ejection fraction (LVEF), N-terminal brain natriuretic peptide (NT-ProBNP) and cardiac troponin T (cTnT) were compared between different prognostic groups. The relative expression levels of miR-126 and miR-130 were compared in the short-term prognostic groups and long-term prognostic groups. Pearson correlation method was used to analyze the correlations of related indexes. Receiver operating characteristic curve was used to analyze the predictive efficacy of relative expression levelsof miR-126 and miR-130 on short-term and long-term prognostic outcomes.
Results The relative expression level of plasma miR-126 in the case group was lower than control group, but the relative expression level of miR-130 in the case group was higher than the control group (P < 0.05). The LVEF in short-term poor prognosis group was lower than that of the short-term good prognosis group, and the expression levels of NT-ProBNP and cTnT in the short-term poor prognosis group were higher than that in the short-term good prognosis group (P < 0.05). The relative expression level of miR-126 in the short term poor prognosis group was lower than that in the short term good prognosis group, while the relative expression level of miR-130 in the short-term poor prognosis group was higher than that in the short-term good prognosis group, and the differences were statistically significant (P < 0.05). The relative expression level of miR-126 in the long term poor prognosis group was lower than that in the long term good prognosis group, while the relative expression level of miR-130 in the long-term poor prognosis group was higher than that in the long-term good prognosis group (P < 0.05). Pearson correlation analysis showed that the relative expression level of miR-126 was positively correlated with LVEF, and negatively correlated with NT-ProBNP and cTnT(P < 0.05). The relative expression level of miR-130 was negatively correlated with LVEF, and positively correlated with NT-ProBNP and cTnT(P < 0.05). The relative expression levels of plasma miR-126 and miR-130 had certain diagnostic efficacy for the short-term prognosis of patients (P < 0.05), but they had low sensitivity and specificity in evaluating the prognosis of patients with MACE 12 months after surgery (P>0.05).
Conclusion Plasma miR-126 and miR-130 have certain significance in evaluating the short-term prognosis after emergency PCI for acute myocardial infarction, and can be used as effective factors for early diagnosis of acute myocardial infarction.
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