Correlations of serum parathyroid hormone and 25 hydroxyvitamin D with glycolipid metabolism in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis

WU Zhen; XU Yan; SU Wentao; WU Gangyong

doi:10.7619/jcmp.20221479

Journal of Clinical Medicine in Practice > 2022 > 26(17): 120-124. > DOI: 10.7619/jcmp.20221479

WU Zhen, XU Yan, SU Wentao, WU Gangyong. Correlations of serum parathyroid hormone and 25 hydroxyvitamin D with glycolipid metabolism in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(17): 120-124. DOI: 10.7619/jcmp.20221479

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Correlations of serum parathyroid hormone and 25 hydroxyvitamin D with glycolipid metabolism in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis

WU Zhen¹,
XU Yan¹,
SU Wentao^{2, 3},
WU Gangyong^2, ,

1.
Department of Renal Endocrinology, the 904th Hospital of the Joint Logistics Support Force of the Chinese People′s Liberation Army, Wuxi, Jiangsu, 214044
2.
Department of Cardiovascular Medicine, the 904th Hospital of the Joint Logistics Support Force of the Chinese People′s Liberation Army, Wuxi, Jiangsu, 214044
3.
Department of Cardiovascular Medicine, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, 214044

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Received Date: May 08, 2022
Available Online: September 20, 2022

Graphical Abstract

Abstract

Abstract

Objective
To analyze the correlations of serum parathyroid hormone (PTH) and 25 hydroxyvitamin D[25-(OH)-D]with glycolipid metabolism in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis (CAS).
Methods
The clinical materials of 110 patients with type 2 diabetes mellitus from April 2019 to December 2021 were collected, and carotid ultrasound, glucose and lipid metabolism examination, and PTH and 25-(OH)-D detections were routinely performed after hospital admission. They were divided into simple type 2 diabetes group (n=51) and CAS group (n=59) according to the results of carotid artery intima-media thickness (CIMT) examination. The levels of PTH, 25-(OH)-D, blood glucose indexes [fasting blood glucose (FBG), glycated hemoglobin (HbA1c)]and blood lipids indexes [total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)]were compared between the two groups, and the relationships of serum PTH and 25-(OH)-D with blood glucose and lipid metabolism were analyzed.
Results
There were no significant differences in gender, age, body mass index and course of disease between the two groups (P > 0.05); the level of serum PTH in the CAS group was significantly higher than that in the simple type 2 diabetes group, while the level of 25-(OH)-D was significantly lower than that in the simple type 2 diabetes group (P < 0.05); the levels of FBG and HbA1c in the CAS group were significantly higher than those in the simple type 2 diabetes group (P < 0.05); levels of TC, TG and LDL-C in the CAS group were significantly higher than those in the simple type 2 diabetes group, while the HDL-C was significantly lower than that in the simple type 2 diabetes group (P < 0.05). The results of bivariate Pearson linear correlation test showed that serum PTH was positively correlated with FBG, HbA1c, TC and TG (P < 0.05), and negatively correlated with HDL-C in patients with type 2 diabetes complicated with CAS (P < 0.05). 25-(OH)-D was negatively correlated with HbA1c, TC and TG (P < 0.01), and positively correlated with HDL-C (P < 0.05).
Conclusion
Serum PTH and 25-(OH)-D levels in type 2 diabetes mellitus patients with CAS are closely related to glucose and lipid metabolism.
- type 2 diabetes mellitus,
- carotid atherosclerosis,
- parathyroid hormone,
- 25 hydroxyvitamin D,
- glucose metabolism,
- lipid metabolism

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References (18)

References

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Correlations of serum parathyroid hormone and 25 hydroxyvitamin D with glycolipid metabolism in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis

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