XU Xiaohang, GAO Hui, ZHAO Jiwei, WANG Yongxiang, SHI Xueqiang, SUN Hao. Risk factors of delirium in patients with severe multiple trauma in trauma center[J]. Journal of Clinical Medicine in Practice, 2022, 26(19): 38-41. DOI: 10.7619/jcmp.20221502
Citation: XU Xiaohang, GAO Hui, ZHAO Jiwei, WANG Yongxiang, SHI Xueqiang, SUN Hao. Risk factors of delirium in patients with severe multiple trauma in trauma center[J]. Journal of Clinical Medicine in Practice, 2022, 26(19): 38-41. DOI: 10.7619/jcmp.20221502

Risk factors of delirium in patients with severe multiple trauma in trauma center

More Information
  • Received Date: May 10, 2022
  • Available Online: October 23, 2022
  • Objective 

    To investigate the occurrence and risk factors of delirium in patients with severe multiple injuries in trauma center.

    Methods 

    A total of 168 patients with severe multiple injuries admitted from June 2021 to January 2022 were selected. The occurrence of delirium was assessed by the Confusion Assessment Method (CAM), and the patients were divided into delirium group (n=65) and non-delirium group (n=103) according to whether delirium occurred. The data of patients were collected and the risk factors of delirium were analyzed.

    Results 

    Clinical data of 168 patients with severe multiple injuries in trauma center were collected, including 65 patients with delirium, with an incidence of 38.69%. There were significant differences in age, mechanical ventilation, hypoxemia (arterial partial pressure of oxygen < 60 mmHg), transferring from ICU to trauma center, coma during trauma, complicating with history of hypertension, brain trauma, invasive operation, and more serious disease between the two groups (P < 0.05). Multivariate Logistic regression analysis showed that age >60 years, mechanical ventilation, hypoxemia (arterial partial pressure of oxygen < 60 mmHg), transferring from ICU to trauma center, coma at the time of trauma, history of hypertension, traumatic brain injury, invasive procedures and severity of illness[Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score>21 scores]were independent risk factors for delirium in patients with severe multiple trauma in trauma center.

    Conclusion 

    Patients with severe multiple injuries in trauma center have higher incidence of delirium that involves many independent risk factorsand exerts influences in a wide range, so the measures should be taken in time when the problems are detected.

  • [1]
    LEE S, GOTTLIEB M, MULHAUSEN P, et al. Recognition, prevention, and treatment of delirium in emergency department: an evidence-based narrative review[J]. Am J Emerg Med, 2020, 38(2): 349-357. doi: 10.1016/j.ajem.2019.158454
    [2]
    MALDONADO J R. Neuropathogenesis of delirium: review of current etiologic theories and common pathways[J]. Am J Geriatr Psychiatry, 2013, 21(12): 1190-1222. doi: 10.1016/j.jagp.2013.09.005
    [3]
    WANG Y R, SHEN X. Postoperative delirium in the elderly: the potential neuropathogenesis[J]. Aging Clin Exp Res, 2018, 30(11): 1287-1295. doi: 10.1007/s40520-018-1008-8
    [4]
    MÉNDEZ-MARTÍNEZ C, FERNÁNDEZ-MARTÍNEZ M N, GARCÍA-SUÁREZ M, et al. Related factors and treatment of postoperative delirium in old adult patients: an integrative review[J]. Healthcare (Basel), 2021, 9(9): 1103.
    [5]
    张雪艳, 邵换璋, 董鑫, 等. ICU谵妄评估工具的研究进展[J]. 中华危重病急救医学, 2018, 30(4): 381-384. doi: 10.3760/cma.j.issn.2095-4352.2018.04.020
    [6]
    WANG C L, WU Y, YUE P, et al. Delirium assessment using Confusion Assessment Method for the Intensive Care Unit in Chinese critically ill patients[J]. J Crit Care, 2013, 28(3): 223-229. doi: 10.1016/j.jcrc.2012.10.004
    [7]
    JIN Z S, HU J, MA D Q. Postoperative delirium: perioperative assessment, risk reduction, and management[J]. Br J Anaesth, 2020, 125(4): 492-504. doi: 10.1016/j.bja.2020.06.063
    [8]
    LIU H, DAI M S, GUAN H L, et al. Preoperative prognostic nutritional index value is related to postoperative delirium in elderly patients after noncardiac surgery: a retrospective cohort study[J]. Risk Manag Healthc Policy, 2021, 14: 1-8. doi: 10.2147/RMHP.S280567
    [9]
    吴传芹, 朱艳萍, 李国宏. ICU患者谵妄的发生率及危险因素分析[J]. 第三军医大学学报, 2018, 40(11): 1038-1043. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201811017.htm
    [10]
    BOWMAN E M L, CUNNINGHAM E L, PAGE V J, et al. Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression[J]. Crit Care, 2021, 25(1): 334. doi: 10.1186/s13054-021-03752-w
    [11]
    胡文琳, 徐娟, 陈茜, 等. 心脏瓣膜置换术后患者ICU谵妄的现况调查[J]. 实用临床医药杂志, 2019, 23(19): 50-52, 68. doi: 10.7619/jcmp.201919013
    [12]
    LI Q X, SHEN Y X, AHMAD A, et al. Mesencephalic astrocyte-derived neurotrophic factor prevents traumatic brain injury in rats by inhibiting inflammatory activation and protecting the blood-brain barrier[J]. World Neurosurg, 2018, 117: e117-e129. doi: 10.1016/j.wneu.2018.05.202
    [13]
    KANOVA M, SKLIENKA P, ROMAN K, et al. Incidence and risk factors for delirium development in ICU patients-a prospective observational study[J]. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2017, 161(2): 187-196. doi: 10.5507/bp.2017.004
    [14]
    宁艳花, 张琳, 王儒林, 等. 危重症患者发生重症监护病房谵妄的危险因素分析[J]. 中国全科医学, 2013, 16(26): 2358-2361. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201326017.htm
    [15]
    陈有玺. 急诊重症患者谵妄发生的临床因素评估及预防性护理[J]. 实用临床医药杂志, 2018, 22(2): 22-24. doi: 10.7619/jcmp.201802007
    [16]
    LUETZ A, GRUNOW J J, MÖRGELI R, et al. Innovative ICU solutions to prevent and reduce delirium and post-intensive care unit syndrome[J]. Semin Respir Crit Care Med, 2019, 40(5): 673-686. doi: 10.1055/s-0039-1698404
    [17]
    GREAVES D, PSALTIS P J, DAVIS D H J, et al. Risk factors for delirium and cognitive decline following coronary artery bypass grafting surgery: a systematic review and meta-analysis[J]. J Am Heart Assoc, 2020, 9(22): e017275. doi: 10.1161/JAHA.120.017275
    [18]
    徐欣, 张振平, 李林泽. 急诊重症监护病房(EICU)患者出现谵妄的危险因素分析[J]. 国际精神病学杂志, 2019, 46(5): 881-884. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ201905034.htm
    [19]
    LIU J, SHEN Q L, ZHANG H P, et al. The potential protective effect of mesencephalic astrocyte-derived neurotrophic factor on post-operative delirium via inhibiting inflammation and microglia activation[J]. J Inflamm Res, 2021, 14: 2781-2791.
    [20]
    YAO L, LI Y L, YIN R Y, et al. Incidence and influencing factors of post-intensive care cognitive impairment[J]. Intensive Crit Care Nurs, 2021, 67: 103106.
  • Cited by

    Periodical cited type(9)

    1. 宋冰冰,王叶舒,卓建洁,黄灵珠. 轻度颅脑损伤患者发生谵妄的危险因素及预防对策. 浙江创伤外科. 2025(02): 396-398 .
    2. 施景源,罗家柳. 脑损伤后谵妄的预防与护理. 创伤外科杂志. 2025(03): 240-241 .
    3. 潘亚强,伍泽民. 急诊脑外伤患者谵妄的影响因素及其风险预测模型的构建. 中国急救复苏与灾害医学杂志. 2024(04): 454-458 .
    4. 范风江,李博,冯丽霞,金钊. 综合ICU严重多发伤患者谵妄发生状况及影响因素分析. 中国实用医刊. 2024(09): 63-66 .
    5. 卢山,王喆懿,周鑫,刘小庆,杨婷婷,徐欢欢,谢晓莉,苏云艳,薛云星. Stanford A型主动脉夹层患者术后谵妄预防及管理的最佳证据总结. 中国临床研究. 2024(09): 1386-1393+1397 .
    6. 侯懿鸣,卢歌敏,曹邓晗,宋向奎. 乌司他丁对多发伤合并感染患者应用价值探讨. 社区医学杂志. 2024(18): 627-631 .
    7. 胡冬雪,牛承志,赵春雨,赵丽丽,王鑫. 基于机器学习的ICU多发伤患者发生谵妄预测模型的构建与评估. 中华创伤杂志. 2024(11): 1016-1021 .
    8. 王德震,梁娟娟,王红梅,刘畅. 一体化创伤急救模式在急诊严重多发伤救治中的应用. 海南医学. 2024(23): 3387-3391 .
    9. 柯炎琼,陈婷婷,沈秀秀. 急诊科多发性创伤患者谵妄发生危险因素分析. 现代实用医学. 2023(04): 478-480 .

    Other cited types(2)

Catalog

    Article views (161) PDF downloads (12) Cited by(11)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return