| Citation: |
LIU Wei, WANG Xiaoxia. Effects of different concentrations of ropivacaine combined with epidural block of nalbuphine on labor analgesia[J]. Journal of Clinical Medicine in Practice, 2022, 26(20): 131-135. DOI: 10.7619/jcmp.20221578
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To investigate the effects of different concentrations of ropivacaine combined with epidural block of nalbuphine on labor analgesia.
A total of 180 singleton primiparas who delivered from January 2019 to January 2021 were selected as the research objects, and were randomly divided into group Ⅰ, group Ⅱ and group Ⅲ, with 60 cases in each group. The group Ⅰ was given 0.100% ropivacaine and 0.3 mg/mL nalbuphine, the group Ⅱ was given 0.125% ropivacaine and 0.3 mg/mL nalbuphine, and the group Ⅲ was given 0.150% ropivacaine and 0.3 mg/mL nalbuphine, all groups were given epidural intermittent injection. The drug administration, onset time of analgesia, visual analogue scale (VAS) score, Bromage score, labor time, delivery mode, Apgar score, blood loss and adverse reactions of parturient women in the three groups were observed.
The onset time of analgesia in the group Ⅲ was significantly shorter than that in the groups Ⅱ and Ⅰ, the frequency of administration was less than that in the groups Ⅱ and Ⅰ, the interval of administration and the time of first patient-controlled analgesia (PCA) were significantly longer than those in the groups Ⅱ and Ⅰ (P < 0.05). There were no significant differences in VAS, Bromage score, time of first stage of labor, incidence of adverse reactions and blood loss among the three groups at different time points (P>0.05). The serum prolactin level and neonates Apgar score at 24 h after delivery in the group Ⅲ were significantly higher than those in the groups Ⅱ and Ⅰ (P < 0.05).
The ropivacaine combined with nalbuphine for epidural labor analgesia is safe, which can significantly reduce maternal labor pain and will not affect the safety of mother and child. 0.150% ropivacaine combined with 0.3 mg/mL nalbuphine has only slight effect on motor nerve block, and the incidence of adverse reactions is low, which can be used as an ideal drug choice program for epidural labor analgesia.
| [1] |
杨胜晗, 王倩, 田玲. 自由体位分娩对产妇产痛、分娩控制感、母婴结局及盆底肌功能的影响[J]. 中国医师进修杂志, 2021(2): 168-174. doi: 10.3760/cma.j.cn115455-20200728-00972
|
| [2] |
CHAN J J I, GAN Y Y, DABAS R, et al. Evaluation of association factors for labor episodic pain during epidural analgesia[J]. J Pain Res, 2019, 12: 679-687. doi: 10.2147/JPR.S185073
|
| [3] |
曹家刚, 李胜华, 冯迪, 等. 不同浓度罗哌卡因复合舒芬太尼分娩镇痛对产妇产间发热的影响[J]. 临床麻醉学杂志, 2019, 35(4): 327-330. https://www.cnki.com.cn/Article/CJFDTOTAL-LCMZ201904004.htm
|
| [4] |
刘书勇. 纳布啡在产科患者术后镇痛中的应用效果[J]. 中国全科医学, 2021, 24(S1): 100-102. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX2021S1038.htm
|
| [5] |
吴畏, 孙鹏飞, 范东梅, 等. 纳布啡复合罗哌卡因连续硬膜外阻滞用于分娩镇痛的效果[J]. 临床麻醉学杂志, 2020, 36(11): 1086-1090. doi: 10.12089/jca.2020.11.010
|
| [6] |
ECHEVARRIA G C, GRANT G J, CHUNG Y, et al. Survey of nulliparous parturients' attitudes regarding timing of epidural analgesia initiation[J]. J Clin Anesth, 2017, 41: 106-111. doi: 10.1016/j.jclinane.2017.06.008
|
| [7] |
蔡孟杰, 庹鹏, 詹鸿, 等. 不同浓度及容量罗哌卡因对剖宫产术后疼痛及快速康复的影响[J]. 中华生物医学工程杂志, 2019, 25(1): 100-104. doi: 10.3760/cma.j.issn.1674-1927.2019.01.019
|
| [8] |
YEFET E, TAHA H, SALIM R, et al. Fixed time interval compared with on-demand oral analgesia protocols for post-Caesarean pain: a randomised controlled trial[J]. BJOG, 2017, 124(7): 1063-1070. doi: 10.1111/1471-0528.14546
|
| [9] |
谭瑛, 梁曼, 张贻岚, 等. 不同浓度罗哌卡因联合舒芬太尼应用于硬膜外分娩镇痛的效果分析[J]. 中国现代手术学杂志, 2018, 22(4): 311-315. https://www.cnki.com.cn/Article/CJFDTOTAL-XDSS201804021.htm
|
| [10] |
WITCHER T J, JURDI S, KUMAR V, et al. Neonatal Resuscitation and Adaptation Score vs Apgar: newborn assessment and predictive ability[J]. J Perinatol, 2018, 38(11): 1476-1482. doi: 10.1038/s41372-018-0189-5
|
| [11] |
鲍秀兰. 新生儿行为能力和测查方法[J]. 实用诊断与治疗杂志, 2003, 17(6): 441-443. doi: 10.3969/j.issn.1674-3474.2003.06.001
|
| [12] |
黄子娟, 王志萍, 梁宵. 艾司氯胺酮联合盐酸罗哌卡因对分娩镇痛及产后抑郁的影响[J]. 中南医学科学杂志, 2021, 49(6): 655-658. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYY202106009.htm
|
| [13] |
KUTHIALA G, CHAUDHARY G. Ropivacaine: a review of its pharmacology and clinical use[J]. Indian J Anaesth, 2011, 55(2): 104-110.
|
| [14] |
时利荣, 陈志强, 王静, 等. 纳布啡在骨科手术麻醉镇痛中的研究进展[J]. 中国现代医学杂志, 2019, 29(20): 43-48. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXDY201920009.htm
|
| [15] |
王楠, 董铁立, 付红光. 舒芬太尼复合纳布啡用于剖宫产术后自控静脉镇痛的效果[J]. 临床麻醉学杂志, 2018, 34(5): 449-451. https://www.cnki.com.cn/Article/CJFDTOTAL-LCMZ201805009.htm
|
| [16] |
汤海珍, 韩雪敏, 赵伟, 等. 盐酸纳布啡复合枸橼酸舒芬太尼在剖宫产术后镇痛中的应用效果[J]. 蚌埠医学院学报, 2019, 44(5): 627-631. https://www.cnki.com.cn/Article/CJFDTOTAL-BANG201905020.htm
|
| [17] |
吴慧红, 李玉茹, 赵君, 等. 纳布啡用于硬膜外分娩镇痛对新生儿脐血血气及乳酸的影响[J]. 广东医学, 2019, 40(18): 2593-2596. https://www.cnki.com.cn/Article/CJFDTOTAL-GAYX201918008.htm
|
| [18] |
申荣坤, 张爱玉. 硬膜外麻醉在无痛分娩过程中的应用研究[J]. 河北医药, 2018, 40(17): 2603-2605, 2610. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201817010.htm
|
| [19] |
李瑞, 罗志锴, 杨丽珍. 不同浓度罗哌卡因复合舒芬太尼在硬膜外镇痛分娩中的效果评价[J]. 实用临床医药杂志, 2018, 22(23): 82-84, 87. doi: 10.7619/jcmp.201823024
|
| [20] |
晏明, 孙剑, 丁松, 等. 罗哌卡因复合纳布啡与罗哌卡因复合芬太尼用于硬膜外分娩镇痛的比较[J]. 国际麻醉学与复苏杂志, 2020, 41(5): 475-478. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202204006.htm
|
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