Relationship between serum vitamin D metabolites and sleep duration among adult women

GONG Heyangzi; XING Lifei; KANG Yimin; WANG Fan

doi:10.7619/jcmp.20221610

Journal of Clinical Medicine in Practice > 2022 > 26(14): 26-30,45. > DOI: 10.7619/jcmp.20221610

GONG Heyangzi, XING Lifei, KANG Yimin, WANG Fan. Relationship between serum vitamin D metabolites and sleep duration among adult women[J]. Journal of Clinical Medicine in Practice, 2022, 26(14): 26-30,45. DOI: 10.7619/jcmp.20221610

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Relationship between serum vitamin D metabolites and sleep duration among adult women

GONG Heyangzi¹,
XING Lifei²,
KANG Yimin¹,
WANG Fan^{1, 3, 4, ,}

1.
College of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010110
2.
Neurointerventional Department, Sinopharm Northern Hospital, Baotou, Inner Mongolia, 014030
3.
Psychiatric Research Center, Beijing Hui Longguan Hospital, Beijing, 100871
4.
Xinjiang Key Laboratory of Neurological Disorder Research, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830063

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Received Date: May 19, 2022
Available Online: July 13, 2022

Graphical Abstract

Abstract

Abstract

Objective
To explore the association between serum vitamin D metabolites and sleep duration in adult women.
Methods
Women aged 20 to 65 in the National Health and Nutrition Examination Survey (NHANES) database were selected as research objects. Serum vitamin D metabolites including 25-hydroxyvitamin D[25(OH)D], 25-hydroxyvitamin D₂[25(OH)D₂] and 25-hydroxyvitamin D₃[25(OH)D₃] were measured using ultra performance liquid chromatography-tandem mass spectrometry. The study objects were divided into sleep deficiency group and non-sleep deficiency group according to varied sleep duration. Logistic regression model and restrictive cubic spline model were used to analyze the relationship between serum vitamin D concentration and sleep condition after adjusting age, race, education level, marital status, economic status, body mass index(BMI), chronic disease status and depression score.
Results
Among 9 353 females, 3 189 (34.1%) had insufficient sleep, including 1 627 (51.0%) aged 20 to 44 years and 1 562 (49.0%) aged 45 to 65 years. With an increase of 10 nmol/L of serum 25(OH)D₃ and 25(OH)D, the incidence of sleep insufficiency decreased by 5.5% and 5.7%, respectively[OR=1.005 5, 95%CI, 1.003 6 to 1.007 3; OR=1.005 7, 95%CI, 1.003 9 to 1.007 6]. The restrictive cubic spline model showed that when serum 25(OH)D₃ is ≤ 70 nmol/L, a strong positive correlation was observed between sleep duration and serum 25(OH)D₃ concentration. However, this positive correlation becomes weaker when serum 25(OH)D₃ was >70 nmol/L.
Conclusion
There is an association between the sleep status and the time of serum concentration of vitamin D metabolites in adult women. The sleep duration varies at different vitamin D concentration levels. When the concentration of serum vitamin D metabolites is low, improvement of level of vitamin D metabolites is more conducive to prolongation of sleep time.
- sleep duration,
- women,
- vitamin D,
- 25-hydroxyvitamin D,
- 25-hydroxyvitamin D₃

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References

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