Effects of different doses of tirofiban combined with diltiazem on long-term and short-term prognosis of high-risk unstable angina pectoris

Objective To investigate effects of different doses of tirofiban combined with diltiazem on long-term and short-term prognosis of high-risk unstable angina pectoris(UAP).

Methods A total of 100 patients with angina pectoris were randomly selected and divided into observation group (n=50) and control group (n=50) according to different treatment methods. The control group was treated with conventional dose of tirofiban combined with diltiazem, and the observation group was treated with low dose tirofiban combined with diltiazem. Occurrence of adverse reactions, hemorheology, blood lipid levelstotal cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and heart function indexesbrain sodium peptide(BNP), left ventricular ejection fraction (LVEF) and angina pectoris attack after 6 months of follow-up were compared.

Results After treatment, the serum TC, TG, LDL-C, plasma viscosity, hematokrit, erythrocyte sedimentation rate and BNP levels in both groups were lower than those before treatment, and the levels of HDL-C and LVEF were higher than before treatment (P < 0.05); compared with the control group, the serum TC, TG, LDL-C, plasma viscosity, hematokrit, red blood cell sedimentation rate, and BNP level in the observation group were lower, and HDL-C and LVEF levels were higher after treatment (P < 0.05); after 6 months, the duration of angina pectoris was shorter, and the number of episodes was decreased in both groups (P < 0.05); the duration of angina pectoris in the observation group was shorter than that of control group, and the number of attacks was less than that in the control group(P < 0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group (16.00% versus 4.00%, P < 0.05).

Conclusion Low-dose tirofiban combined with diltiazem can improve cardiac function of high-risk UAP patients, reduce the frequency of angina pectoris, effectively regulate blood lipid levels and improve hemorheology.