QIAO Mu, HAN Yanyan, YAO Wenxiu. Clinical significance of 25-hydroxyvitamin D and lactate dehydrogenase in detecting neonates infected with group B hemolytic Streptococcus[J]. Journal of Clinical Medicine in Practice, 2023, 27(4): 44-47, 65. DOI: 10.7619/jcmp.20222154
Citation: QIAO Mu, HAN Yanyan, YAO Wenxiu. Clinical significance of 25-hydroxyvitamin D and lactate dehydrogenase in detecting neonates infected with group B hemolytic Streptococcus[J]. Journal of Clinical Medicine in Practice, 2023, 27(4): 44-47, 65. DOI: 10.7619/jcmp.20222154

Clinical significance of 25-hydroxyvitamin D and lactate dehydrogenase in detecting neonates infected with group B hemolytic Streptococcus

More Information
  • Received Date: July 13, 2022
  • Available Online: March 14, 2023
  • Objective 

    To investigate the changes in serum levels of 25-hydroxyvitamin D [25-(OH)D] and lactate dehydrogenase (LDH) in neonates with sepsis induced by group B hemolytic streptococcus (GBS) and their clinical significance.

    Methods 

    A total of 204 children with GBS infection were elected as research objects. According to the occurrence condition of sepsis, they were divided into GBS infection group (n=103) and sepsis group (n=101), and 105 cases of healthy newborns were selected as control group. The serum 25-(OH)D and LDH levels were detected and their correlation was analyzed; the predictive value of 25-(OH)D and LDH for neonatal GBS-infected sepsis was evaluated by receiver operating characteristic (ROC) curve; the influencing factors of neonatal GBS infection sepsis were analyzed.

    Results 

    The serum 25-(OH)D level of children in the GBS infection group was significantly lower than that in the control group, and the LDH level was significantly higher than that in the control group (P < 0.05); the serum 25-(OH)D level of children in the sepsis group was significantly lower than that in the GBS infection group, and the LDH level was significantly higher than that in the GBS infection group (P < 0.05). The levels of serum 25-(OH)D and LDH were negatively correlated in those of neonatal GBS infected with sepsis (P < 0.05); the area under ROC curve (AUC) of 25-(OH)D and LDH combined predicted neonatal GBS infection with sepsis was greater than that of 25-(OH)D and LDH separately assessed (P < 0.05). Serum 25-(OH)D and LDH were risk factors for neonatal GBS infection with sepsis (P < 0.05).

    Conclusion 

    The serum 25-(OH)D level is abnormally decreased and LDH level is abnormally increased in neonates with GBS infected sepsis. The detection of both levels is of great significance for early prediction and prevention of neonatal GBS infected sepsis.

  • [1]
    扎西吉, 吕文华. 早发型新生儿B族溶血链球菌感染的临床特征及相关危险因素分析[J]. 解放军预防医学杂志, 2018, 36(10): 1293-1296.
    [2]
    刘利, 高玲玲, 周冰侠. 孕晚期B族溶血性链球菌感染的危险因素分析[J]. 实用临床医药杂志, 2021, 25(14): 37-40. doi: 10.7619/jcmp.20211173
    [3]
    陶志允, 林多华, 杜佩珍, 等. 新生儿B族链球菌败血症临床特征分析及白细胞介素6检测的诊断价值[J]. 中国感染与化疗杂志, 2019, 19(5): 478-482. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201905004.htm
    [4]
    OLUSOLA F, SOTUNDE. Maternal risk factors and newborn infant vitamin D status: a scoping literature review[J]. Nutr Res, 2019, 63: 1-20. doi: 10.1016/j.nutres.2018.11.011
    [5]
    雷冰, 栗文娟, 蔡瑞瑞, 等. 早产儿血清25-羟维生素D和维生素D结合蛋白水平与支气管肺发育不良的关系[J]. 中华新生儿科杂志: 中英文, 2019(4): 259-263. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202217005.htm
    [6]
    CEPEDA S J, ZENTENO A D, FUENTES S C, et al. Vitamin D and pediatrics respiratory diseases[J]. Rev Chil Pediatr, 2019, 90(1): 94-101. doi: 10.32641/rchped.v90i1.747
    [7]
    MALDONADO V, HERNANDEZ-RAMÍREZ C, OLIVA-PÉREZ E A, et al. Pentoxifylline decreases serum LDH levels and increases lymphocyte count in COVID-19 patients: results from an external pilot study[J]. Int Immunopharmacol, 2021, 90: 107209. doi: 10.1016/j.intimp.2020.107209
    [8]
    LI C, YE J F, CHEN Q J, et al. Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19[J]. Aging (Albany NY), 2020, 12(15): 15670-15681.
    [9]
    中华医学会儿科学分会新生儿学组, 中国医师协会新生儿科医师分会感染专业委员会. 新生儿败血症诊断及治疗专家共识(2019年版)[J]. 中华儿科杂志, 2019, 57(4): 252-257.
    [10]
    付宇, 肖迪. 孕妇生殖道B族链球菌感染对母婴预后的影响[J]. 实用临床医药杂志, 2020, 24(15): 58-60, 64. doi: 10.7619/jcmp.202015016
    [11]
    范小萍, 叶旭芳, 毛月燕, 等. 新生儿GBS感染败血症患儿血乳酸和血清炎症指标水平及临床意义[J]. 中国妇幼保健, 2020, 35(24): 4764-4766. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202024038.htm
    [12]
    宋丹, 刘静, 梅花, 等. 蒙、汉族孕妇B族链球菌定植及新生儿早发型败血症状况的研究[J]. 中华急诊医学杂志, 2022, 31(2)233-240
    [13]
    潘彩琴, 张雪梅, 符婷, 等. 炎症因子水平对新生儿B族链球菌败血症的诊断价值[J]. 中华医院感染学杂志, 2021, 31(4): 590-593. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202104025.htm
    [14]
    KASSAI M S, CAFEO F R, AFFONSO-KAUFMAN F A, et al. Vitamin D plasma concentrations in pregnant women and their preterm newborns[J]. BMC Pregnancy Childbirth, 2018, 18(1): 412.
    [15]
    PANDA M, MCINTOSH J, CHAUDHARI T, et al. Do maternal vitamin D levels influence vitamin D levels in preterm neonates[J]. Int J Pediatr, 2019, 2019: 8613414.
    [16]
    郑双双, 詹建英, 朱冰泉, 等. 中国儿童维生素D营养状况流行病学研究进展[J]. 中华儿科杂志, 2019, 57(3): 232-234.
    [17]
    AGRAWAL A, GUPTA A, SHRIVASTAVA J. Role of vitamin-D deficiency in term neonates with late-onset Sepsis: a case-control study[J]. J Trop Pediatr, 2019, 65(6): 609-616.
    [18]
    魏从真, 孙静娜, 陈正立, 等. 新生儿败血症血清25(OH)D与免疫球蛋白水平变化分析[J]. 标记免疫分析与临床, 2020, 27(4): 546-551. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY202004002.htm
    [19]
    沈蕾蕾, 唐仕芳, 陈龙, 等. 维生素D缺乏与新生儿疾病关系的研究进展[J]. 医学综述, 2020, 26(22): 4483-4488, 4493. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZS202022022.htm
    [20]
    MISHRA M, HIMANSHU D, SAWLANI K K. Role of CSF-LDH and serum LDH levels to diff erentiate between diff erent types of meningitis[J]. J Assoc Physicians India, 2020, 68(1): 61.
    [21]
    黄诗琦, 韦雅妮, 赵雨川, 等. 鸡血藤总黄酮对大肠杆菌败血症的治疗作用[J]. 中国畜牧兽医, 2019, 46(5): 1541-1550. https://www.cnki.com.cn/Article/CJFDTOTAL-GWXK201905035.htm
    [22]
    魏博涛, 马翠安, 沈阳, 等. 腺病毒感染患儿急性胃肠炎表型列线图预测模型的建立及验证[J]. 天津医药, 2022, 50(1): 99-103. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ202201019.htm
  • Cited by

    Periodical cited type(11)

    1. 朱丹,刘采连. 肝郁气滞型持续性姿势-感知性头晕患者运用柴胡疏肝散的疗效研究. 中外医学研究. 2025(06): 107-110 .
    2. 郭甜甜,彭壮,付晓芳. 逍遥解郁方联合前庭康复训练治疗持续性姿势-知觉性头晕临床观察. 实用中医药杂志. 2024(01): 39-41 .
    3. 张俊红,王丽,郑银燕,张佰景,张俊梅. 低频经颅磁刺激联合前庭康复训练治疗持续性姿势-感知性头晕的疗效观察. 中华物理医学与康复杂志. 2024(04): 317-321 .
    4. 史林娟,赵蕾,孙文青,宋红娜. 前庭康复训练联合艾司西酞普兰片治疗持续性姿势知觉性头晕的疗效. 慢性病学杂志. 2024(10): 1504-1506+1510 .
    5. 徐金凤,魏辰鸿,汪毅明,杨建波,魏建刚,张倩,林晓静,张小宁. 前庭康复训练法治疗中重度持续性姿势-感知性头晕的临床疗效分析. 中国临床神经科学. 2023(01): 43-48 .
    6. 贾云朋,王彩娟,纪朋曼,曹俊英,孟曙龙,田丹丹,赵扬,杨静棉. 灯银脑通胶囊治疗持续性姿势感知性头晕的作用机制研究. 世界中西医结合杂志. 2023(06): 1242-1245+1256 .
    7. 时钦,江炜炜,唐睩,刘红星,李峰,张丽. 草酸艾司西酞普兰配合视觉脱敏训练治疗老年持续性姿势-知觉性头晕的效果. 医学研究与战创伤救治. 2023(11): 1182-1187 .
    8. 马小琦. 持续性姿势知觉性头晕患者睡眠障碍与认知功能障碍相关性研究. 中国实用医药. 2022(04): 73-75 .
    9. 李锋森,孟毅,乔明亮,成家宏. 前庭康复训练联合药物疗法治疗持续性姿势-知觉性头晕的Meta分析. 神经损伤与功能重建. 2022(05): 264-268+306 .
    10. 张芳,俞晔,罗春香,杨敏,黄志英. 前庭康复训练应用于持续性姿势-知觉性头晕患者的临床研究. 中国医学创新. 2022(20): 150-153 .
    11. 钟伟森,张运如. 中医定向透药联合耳穴压豆治疗老年眩晕病的临床观察. 中医外治杂志. 2022(02): 19-21 .

    Other cited types(5)

Catalog

    Article views (219) PDF downloads (15) Cited by(16)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return