Correlation between dynamic changes of cytokines and condition of disease in patients with simple diabetic retinopathy

BIAN Yun; BAI Hailong; MENG Xiaofeng; LIU Xiao; XUE Chao; LIU Ruixue; CHANG Hongkun; TIAN Fengsheng; CUI Ronggang; SU Yang; LIU Mei

doi:10.7619/jcmp.20222162

Journal of Clinical Medicine in Practice > 2023 > 27(4): 61-65. > DOI: 10.7619/jcmp.20222162

BIAN Yun, BAI Hailong, MENG Xiaofeng, LIU Xiao, XUE Chao, LIU Ruixue, CHANG Hongkun, TIAN Fengsheng, CUI Ronggang, SU Yang, LIU Mei. Correlation between dynamic changes of cytokines and condition of disease in patients with simple diabetic retinopathy[J]. Journal of Clinical Medicine in Practice, 2023, 27(4): 61-65. DOI: 10.7619/jcmp.20222162

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Correlation between dynamic changes of cytokines and condition of disease in patients with simple diabetic retinopathy

1.
the Third Department of Diabetes, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Cangzhou, Hebei, 061001
2.
Center for Preventive Treatment of Disease, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Cangzhou, Hebei, 061001
3.
the Second Department of Ultrasound, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Cangzhou, Hebei, 061001
4.
Department of Ophthalmology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Cangzhou, Hebei, 061001

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Received Date: July 13, 2022
Available Online: March 14, 2023

Graphical Abstract

Abstract

Abstract

Objective
To explore the correlation between dynamic changes of cytokines and condition of disease in patients with simple diabetic retinopathy (DR).
Methods
A total of 222 patients with simple DR in authors' hospital from October 2020 to March 2021 were prospectively selected as the research objects, and they were divided into proliferative diabetic retinopathy (PDR) group and non-PDR group according to the disease outcome after a year of follow up. General materials and cytokine levels were compared between the two groups, and the multivariate Logistic regression model was used to analyze the related factors affecting the condition of disease in patients with simple DR.
Results
Up to April, 2022, 5 cases were lost during follow-up, and 217 cases were finally included, with a follow-up rate of 97.75%; among the 217 cases, 61 cases (28.11%) with PDR were selected as PDR group, and 156 cases (71.89%) without PDR were selected as non-PDR group. There were significant differences in the change rates of serum vascular endothelial growth factor (VEGF), interleukin-18 (IL-18) and interleukin-1β (IL-1β) between the two groups (P < 0.05). Multivariate Logistic regression analysis showed that change rate of after 1 year follow-up and according to the outcome of the disease vascular endothelial growth factor VEGF (OR=1.054, 95%CI, 1.047 to 1.061), change rate of IL-18 (OR=1.163, 95%CI, 1.150 to 1.175) and change rate of IL-1β (OR= 1.132, 95%CI, 1.120 to 1.144) were the risk factors for the progression of simple DR (P < 0.001).
Conclusion
The dynamic changes of VEGF, IL-1β and IL-18 are related to the change of disease in patients with simple DR.

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References

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