Expression of pro-inflammatory factors and oxidative stress index in young children with suppurative meningitis

HAN Ying; GUO Peng; LEI Yujiao; LIU Yang; LEI Ruirui

doi:10.7619/jcmp.20222303

Journal of Clinical Medicine in Practice > 2023 > 27(8): 105-108. > DOI: 10.7619/jcmp.20222303

HAN Ying, GUO Peng, LEI Yujiao, LIU Yang, LEI Ruirui. Expression of pro-inflammatory factors and oxidative stress index in young children with suppurative meningitis[J]. Journal of Clinical Medicine in Practice, 2023, 27(8): 105-108. DOI: 10.7619/jcmp.20222303

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Expression of pro-inflammatory factors and oxidative stress index in young children with suppurative meningitis

1.
Pediatric Department of Internal Medicine, Zhumadian Central Hospital of Henan Province, Zhumadian, Henan, 463000
2.
Department of Pediatric Intensive Care, Zhumadian Central Hospital of Henan Province, Zhumadian, Henan, 463000
3.
Department of Neonatology, Zhumadian Central Hospital of Henan Province, Zhumadian, Henan, 463000

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Received Date: July 27, 2022
Revised Date: February 05, 2023
Available Online: May 10, 2023

Graphical Abstract

Abstract

Abstract

Objective
To explore the expression and clinical significance of pro-inflammatory factors and oxidative stress indicators in young children with purulent meningitis (PM).
Methods
Clinical data of 60 children with PM were retrospectively analyzed, and they were divided into normal PM group (36 cases) and severe PM group (24 cases) according to the degree of disease progression. Another 50 children with non-central infectious diseases were selected as control group. The levels of proinflammatory factors [tumor necrosis factor-α (TNF-α), macrophagic inflammatory protein-1α (MIP-1α), interleukin-6 (IL-6) and interleukin-8 (IL-8)] and oxidative stress indexes [superoxide dismutase (SOD), malondialdehyde (MDA) and nitrogen monoxide (NO)] in cerebrospinal fluid of the three groups were compared. Spearman correlation analysis was used to analyze the relationship between the level of related indicators and the severity of PM children.
Results
The IL-6 levels in the severe PM group and normal PM group were significantly higher than that in the control group (P < 0.05). The levels of TNF-α and IL-8 in the severe PM group and the normal PM group were significantly higher than those in the control group, and the severe PM group was significantly higher than that in the normal PM group (P < 0.05). The levels of MDA and NO in the severe PM group and the normal PM group were significantly higher than those in the control group, and the severe PM group was significantly higher than that in the normal PM group (P < 0.05). The SOD levels of the severe PM group and normal PM group were significantly higher than those of the control group (P < 0.05). The severity of PM disease was positively correlated with the levels of TNF-α (r=0.354), IL-8 (r=0.397), MDA (r=0.437) and NO (r=0.456) (P < 0.05 or P < 0.01).
Conclusion
Disease progression in children with PM is related to the level of proinflammatory cytokines and oxidative stress response. Clinical diagnosis and treatment of PM children can be based on the above indicators.
- pro-inflammatory factors,
- oxidative stress,
- purulent meningitis,
- low-aged children

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