Objective To investigate the occurrence of microvascular lesions in patients with type 2 diabetes mellitus (T2DM) complicated with hyperuricemia (HUA), and its influencing factors.
Methods A total of 102 patients with T2DM and HUA were selected as study objects, and were divided into microvascular disease group (n=59) and non-microvascular disease group (n=43) according to whether they occurred microvascular disease or not. The general data, blood pressure, glucose and lipid metabolism indexes and renal function indexes were compared between the two groups. Multivariate Logistic regression analysis was used to explore the influencing factors of microvascular disease in T2DM patients complicated with HUA.
Results Age, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBP), fasting blood glucose (FBG), serum glycated hemoglobin (HbA1c), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and blood uric acid (SUA) levels in the microvascular disease group were significantly higher than those in the non-microvascular disease group, duration of diabetes was longer than that of the non-microvascular disease group, and the estimated glomerular filtration rate (eGFR) was significantly lower than that in the non-microvascular disease group (P < 0.05). There were no significant differences in gender composition, smoking history, drinking history, diastolic blood pressure (DBP), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), blood urea nitrogen (BUN) and serum creatinine (Scr) between the two groups (P>0.05). Logistic regression analysis showed that WHR, hypertension, duration of diabetes, SBP, HbA1c, SUA and LDL-C were independent risk factors for microvascular disease in T2DM patients with HUA (P < 0.05).
Conclusion T2DM patients with HUA have higher risk of microvascular disease, and WHR, hypertension, disease duration, SBP and levels of HbA1c, SUA and LDL-C are all risk factors for microvascular disease.
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