LI Qian, LI Xiaojing, LI Xinyi. Research progress on secreted protein acidic and rich in cysteine in skin fibrosis disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(6): 137-140. DOI: 10.7619/jcmp.20222597
Citation: LI Qian, LI Xiaojing, LI Xinyi. Research progress on secreted protein acidic and rich in cysteine in skin fibrosis disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(6): 137-140. DOI: 10.7619/jcmp.20222597

Research progress on secreted protein acidic and rich in cysteine in skin fibrosis disease

More Information
  • Received Date: August 21, 2022
  • Revised Date: December 11, 2022
  • Available Online: April 11, 2023
  • The main pathological feature of skin fibrosis disease is the excessive deposition of extracellular matrix (ECM) dominated by collagen in the dermis, which can lead to skin thickening or hypertrophic scar. Typical fibrotic lesions of the skin include scleroderma, hypertrophic scars and keloids. Studies found that secreted protein acidic and rich in cysteine (SPARC) is overexpressed in various fibrotic tissues. SPARC is a typical calcium binding matrix protein that can regulate interactions between cells and ECM, and affect responses of cells to growth factors. This study reviewed the research progress of SPARC in skin fibrosis so as to provide evidence for SPARC as a potential target for alleviating fibrosis.

  • [1]
    ROSSET E M, BRADSHAW A D. SPARC/osteonectin in mineralized tissue[J]. Matrix Biol, 2016(52/53/54): 78-87.
    [2]
    BRADSHAW A D. The role of SPARC in extracellular matrix assembly[J]. J Cell Commun Signal, 2009, 3(3): 239-246.
    [3]
    WANG L Y, ZHANG Y T, DU L Q, et al. The effect of SPARC on the proliferation and migration of limbal epithelial stem cells during the corneal epithelial wound healing[J]. Stem Cells Dev, 2021, 30(6): 301-308. doi: 10.1089/scd.2020.0196
    [4]
    WONG S L I, SUKKAR M B. The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease[J]. Br J Pharmacol, 2017, 174(1): 3-14. doi: 10.1111/bph.13653
    [5]
    TROMBETTA-ESILVA J, BRADSHAW A D. The function of SPARC as a mediator of fibrosis[J]. Open Rheumatol J, 2012, 6: 146-155. doi: 10.2174/1874312901206010146
    [6]
    OH D J, KANG M H, OOI Y H, et al. Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix[J]. Invest Ophthalmol Vis Sci, 2013, 54(5): 3309-3319. doi: 10.1167/iovs.12-11362
    [7]
    HARRIS B S, ZHANG Y H, CARD L, et al. SPARC regulates collagen interaction with cardiac fibroblast cell surfaces[J]. Am J Physiol Heart Circ Physiol, 2011, 301(3): H841-H847. doi: 10.1152/ajpheart.01247.2010
    [8]
    RENTZ T J, POOBALARAHI F, BORNSTEIN P, et al. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts[J]. J Biol Chem, 2007, 282(30): 22062-22071. doi: 10.1074/jbc.M700167200
    [9]
    CARAFOLI F, BIHAN D, STATHOPOULOS S, et al. Crystallographic insight into collagen recognition by discoidin domain receptor 2[J]. Structure, 2009, 17(12): 1573-1581. doi: 10.1016/j.str.2009.10.012
    [10]
    RILEY H J, BRADSHAW A D. The influence of the extracellular matrix in inflammation: findings from the SPARC-null mouse[J]. Anat Rec (Hoboken), 2020, 303(6): 1624-1629. doi: 10.1002/ar.24133
    [11]
    FAN J W, ZHANG X, JIANG Y P, et al. SPARC knockdown attenuated TGF-β1-induced fibrotic effects through Smad2/3 pathways in human pterygium fibroblasts[J]. Arch Biochem Biophys, 2021, 713: 109049. doi: 10.1016/j.abb.2021.109049
    [12]
    BRADSHAW A D, GRAVES D C, MOTAMED K, et al. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight[J]. Proc Natl Acad Sci USA, 2003, 100(10): 6045-6050. doi: 10.1073/pnas.1030790100
    [13]
    ZHOU X D, TAN F K, GUO X J, et al. Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma[J]. Arthritis Rheum, 2006, 54(8): 2626-2631. doi: 10.1002/art.21973
    [14]
    WANG J C, SONNYLAL S, ARNETT F C, et al. Attenuation of expression of extracellular matrix genes with siRNAs to Sparc and Ctgf in skin fibroblasts of CTGF transgenic mice[J]. Int J Immunopathol Pharmacol, 2011, 24(3): 595-601. doi: 10.1177/039463201102400305
    [15]
    WANG J C, LAI S, GUO X J, et al. Attenuation of fibrosis in vitro and in vivo with SPARC siRNA[J]. Arthritis Res Ther, 2010, 12(2): R60. doi: 10.1186/ar2973
    [16]
    ZHOU X D, TAN F K, GUO X J, et al. Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts[J]. Arthritis Rheum, 2005, 52(1): 257-261. doi: 10.1002/art.20785
    [17]
    CARVALHEIRO T, MALVAR FERNÁNDEZ B, OTTRIA A, et al. Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts[J]. Rheumatology (Oxford), 2020, 59(9): 2258-2263. doi: 10.1093/rheumatology/kez583
    [18]
    ANTIGNANI A. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?[J]. Curr Opin Cell Biol, 2006, 18(6): 685-689. doi: 10.1016/j.ceb.2006.10.004
    [19]
    LI Y, YANG L L, ZHENG Z, et al. MRP1 knockdown down-regulates the deposition of collagen and leads to a reduced hypertrophic scar fibrosis[J]. J Mol Hist, 2015, 46(4): 357-364.
    [20]
    XIAO Z B, QU G F. Effects of botulinum toxin type a on collagen deposition in hypertrophic scars[J]. Molecules, 2012, 17(2): 2169-2177. doi: 10.3390/molecules17022169
    [21]
    刘超华, 李小静, 宁金龙, 等. 富含半胱氨酸的酸性分泌糖蛋白在病理性瘢痕中的表达及其意义[J]. 组织工程与重建外科杂志, 2010, 6(1): 17-20. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZCW201001009.htm
    [22]
    朱晓璇, 李心怡, 王佳妮, 等. Sparc对瘢痕疙瘩成纤维细胞以及正常人皮肤成纤维细胞增殖凋亡及Ⅰ型、Ⅲ型胶原分泌影响的研究[J]. 安徽医科大学学报, 2021, 56(8): 1222-1225. https://www.cnki.com.cn/Article/CJFDTOTAL-YIKE202108010.htm
    [23]
    王春, 李小静, 刘超华, 等. SPARC对增生性瘢痕成纤维细胞Ⅰ型胶原蛋白mRNA表达的影响[J]. 山东医药, 2009, 49(50): 110-111. doi: 10.3969/j.issn.1002-266X.2009.50.055
    [24]
    WENG X J, LI X J, LI X Y. Promotion of fibrosis in skin scar tissue by secreted protein acidic which is rich in cysteine proteins[J]. J Biomater Tiss Eng, 2018, 8(11): 1573-1579. doi: 10.1166/jbt.2018.1907
    [25]
    LIANG P F, LV C L, JIANG B M, et al. MicroRNA profiling in denatured dermis of deep burn patients[J]. Burns, 2012, 38(4): 534-540. doi: 10.1016/j.burns.2011.10.014
    [26]
    WANG L Y, ZHANG Y T, DU L Q, et al. The effect of SPARC on the proliferation and migration of limbal epithelial stem cells during the corneal epithelial wound healing[J]. Stem Cells Dev, 2021, 30(6): 301-308. doi: 10.1089/scd.2020.0196
  • Related Articles

    [1]ZHANG Li, BAI Jing, YAN Jingxiao, WANG Haijie, ZHANG Yan. Application of transvaginal ultrasound, multimodal magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission computed tomography/computed tomography in diagnosis of endometrial carcinoma[J]. Journal of Clinical Medicine in Practice, 2025, 29(4): 69-72, 77. DOI: 10.7619/jcmp.20243701
    [2]LI Xiaolu, HUO Liqun, GU Jun. Research progress on positron emission tomography/magnetic resonance imaging in diagnosis and treatment of breast cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(24): 115-119. DOI: 10.7619/jcmp.20231580
    [3]YE Linhui, GAO Zengxin, BAO Xianguo, GUO Changzheng, CHENG Changgui, LI Zigang, CHEN Youmin. Effect of X-ray and magnetic resonance imaging in treating patients with different types of osteoporotic thoracolumbar fracture by percutaneous kyphoplasty[J]. Journal of Clinical Medicine in Practice, 2023, 27(12): 6-10. DOI: 10.7619/jcmp.20231154
    [4]ZHANG Zhixiang, CUI Bo, LI Tianyun, XIE Fei. Multi-slice spiral computed tomography versus gadolinium diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging in follow-up of primary hepatic cancer after transcatheter hepatic arterial chemoembolization[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 9-13. DOI: 10.7619/jcmp.20222213
    [5]WU Jianyue, NI Yingjie, RUI Yufeng, XU Lin, ZHANG Dong. A clinical analysis of hidden blood loss in elderly patients with intertrochanteric fracture of femur during perioperative period[J]. Journal of Clinical Medicine in Practice, 2022, 26(4): 60-63. DOI: 10.7619/jcmp.20213220
    [6]ZHOU Chunshan, HUANG Yan, YAN Wenchao. Value of computed tomography scan versus magnetic resonance imaging in the diagnosis of pancreatic cystadenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(20): 47-50. DOI: 10.7619/jcmp.202020013
    [7]YANG Jialin, ZHANG Yutang, FU Bingjin, MENG Xianglin, ZHU Xiaodong. Value of 3D printing technology in auxiliary treatment of calcaneal fractures of Sanders type Ⅱ or type Ⅲ[J]. Journal of Clinical Medicine in Practice, 2020, 24(13): 29-32. DOI: 10.7619/jcmp.202013009
    [8]LU Cuihong, ZHANG Baoyuan. Brain computed tomography findings and their diagnostic value in elderly patients with cerebral hemorrhage[J]. Journal of Clinical Medicine in Practice, 2019, 23(24): 8-10. DOI: 10.7619/jcmp.201924003
    [9]TIAN Juan, WANG Huifang, DONG Jianghua. Value of abdominal computed tomography in evaluating extramural vascular invasion of gastric cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(7): 29-31, 36. DOI: 10.7619/jcmp.201907008
    [10]WANG Dongdong, SUN Hongzhi, GUO Xiaowen, CHEN Kai. Value of percutaneous balloon dilatation combined with hydroxyapatite in the treatment of sander Ⅱ, type Ⅲ fracture of calcaneus[J]. Journal of Clinical Medicine in Practice, 2014, (21): 78-80. DOI: 10.7619/jcmp.201421022
  • Cited by

    Periodical cited type(2)

    1. 史梦,蔡雪芹,李琼. NLR IL-6 CRP与重症肺炎合并感染性休克患者预后的关系研究. 河北医学. 2024(12): 2054-2059 .
    2. 张诚实,徐明华,张青,冯契靓,王妮妮,陈荣荣,赵云峰. 平均血小板体积与血小板计数比值对老年呼吸衰竭患者预后的评估价值. 老年医学与保健. 2023(05): 964-968 .

    Other cited types(1)

Catalog

    Article views (177) PDF downloads (9) Cited by(3)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return