Meta-analysis of efficacy of Shengjing Capsules (Tablets) in the treatment of oligoasthenospermia

JIANG Haoyue; YU Shujun; TANG Yibo; SHEN Zhenru; LIU Zhejun; TANG Tian; WANG Shuaiqiang; TONG Kejin; LIU Zhenquan

doi:10.7619/jcmp.20222610

Journal of Clinical Medicine in Practice > 2022 > 26(21): 46-54. > DOI: 10.7619/jcmp.20222610

JIANG Haoyue, YU Shujun, TANG Yibo, SHEN Zhenru, LIU Zhejun, TANG Tian, WANG Shuaiqiang, TONG Kejin, LIU Zhenquan. Meta-analysis of efficacy of Shengjing Capsules (Tablets) in the treatment of oligoasthenospermia[J]. Journal of Clinical Medicine in Practice, 2022, 26(21): 46-54. DOI: 10.7619/jcmp.20222610

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Meta-analysis of efficacy of Shengjing Capsules (Tablets) in the treatment of oligoasthenospermia

1.
College of Traditional Chinese Medicine, College of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210023
2.
School of Chinese Materia Medica of Beijing University of Chinese Medicine, Beijing, 102488
3.
School of Traditional Chinese Medicine of Beijing University of Chinese Medicine, Beijing, 102488

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Received Date: August 22, 2022
Available Online: November 07, 2022

Graphical Abstract

Abstract

Abstract

Objective
To systematically review the effectiveness of Shengjing Capsules (Tablets) in the treatment of oligoasthenozoospermia.
Methods
The random controlled trials (RCT) of Shengjing Capsules (Tablets) in treating oligoasthenospermia in China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), China Science and Technology Journal Database(VIP), the Cochrane Library and PubMed were searched by computers, and the search time was from the establishment of the database to August 9, 2022. Literature review was conducted by two researchers according to the search methods, and the literatures were screened for inclusion and exclusion. RevMan 5.4 software was used for meta-analysis.
Results
A total of 26 literatures were included, with a total of 2 902 samples. Meta-analysis result show that the total effective rate of trail group treated with Shengjing Capsules (Tablets) was significantly higher than that of the control group(RR=1.41, 95%CI, 1.25 to 1.60, P < 0.000 01), and the improvementsin semen volume (MD=0.50, 95%CI, 0.30 to 0.71, P < 0.000 01), semen density(MD=12.39, 95%CI, 9.19 to15.59, P < 0.000 01), sperm rate ofgrade a (MD=7.24, 95%CI, 4.39 to 10.08, P < 0.000 01) and sperm rate of gradea plus b(MD=9.00, 95%CI, 3.25 to 18.15, P < 0.000 01) were significantly better than those of the control group.
Conclusion
Meta-analysis study shows that Shengjing Capsules (Tablets) is effective in the treatment of oligoasthenospermia, but we still need more RCTs with high quality and large samples to provide high-level evidence-based medical data.
- Shengjing Capsules (Tablets),
- oligoasthenospermia,
- meta-analysis,
- randomized controlled trials

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References (34)

References

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Meta-analysis of efficacy of Shengjing Capsules (Tablets) in the treatment of oligoasthenospermia

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